** Medical equipment maker Mettler-Toledo International's shares MTD.N rise 2.71% to $1,394 premarket

** Co forecast annual profit above estimates, banking on strong demand for its laboratory instruments used in drug development

** Sees 2025 adj profit per share to be between $42.35 and $43.00, above analysts' estimates of $42.13 per share - data compiled by LSEG

** Posts Q4 adj profit per share of $12.41, beating estimates of $11.71 per share

** Co's Q4 sales rose 12% to $1.05 billion, above estimates of $1.01 billion

** Up to last close, stock had risen 8.82% in the last 12 months

(Reporting by Siddhi Mahatole)

((siddhiprabhanjan.mahatole@thomsonreuters.com))