Press Release: SOPHiA GENETICS Reports Fourth Quarter and Full Year 2024 Results

Dow Jones
03-04

SOPHiA GENETICS Reports Fourth Quarter and Full Year 2024 Results

PR Newswire

BOSTON and ROLLE, Switzerland, March 4, 2025

BOSTON and ROLLE, Switzerland, March 4, 2025 /PRNewswire/ -- SOPHiA GENETICS (Nasdaq: SOPH), a cloud-native software company and leader in data-driven medicine, today reported financial results for its fourth quarter and fiscal year ended December 31, 2024.

Fourth Quarter 2024 Financial Highlights

   -- Revenue was $17.7 million, up 4% year-over-year or 6% on a constant 
      currency basis excluding COVID-19-related revenue 
 
   -- Gross margin was 68.2% on a reported basis and 74.2% on an adjusted basis, 
      compared to 69.8% and 73.4% in the prior year period, respectively 
 
   -- Operating loss was $17.4 million on a reported basis and $10.2 million on 
      an adjusted basis, representing year-over-year improvements of 8% and 23%, 
      respectively 

Full Year 2024 Financial Highlights

   -- Revenue was $65.2 million, up 4% year-over-year or 5% on a constant 
      currency basis excluding COVID-19-related revenue 
 
   -- Gross margin was 67.4% on a reported basis and 72.8% on an adjusted basis, 
      compared to 68.8% and 72.2% in the prior year period, respectively 
 
   -- Operating loss was $66.6 million on a reported basis and $44.8 million on 
      an adjusted basis, representing year-over-year improvements of 11% and 
      20%, respectively 

"We continued driving widespread adoption of SOPHiA DDM$(TM)$ in 2024, achieving a record number of analyses, major new customers wins, and healthy volume growth during the year, despite BioPharma headwinds which impacted overall performance and resulted in softer revenue growth than we would have liked," said Jurgi Camblong, PhD., Chief Executive Officer and Co-founder. "We also refueled the Company's growth engine in 2024 by launching an exciting suite of new products and signing a record number of new customers, all while making meaningful improvements to both operating expenses and gross margin."

Camblong added, "Looking forward to 2025, we are well positioned to reaccelerate growth. Catalysts for the year include the new Liquid Biopsy application MSK-ACCESS$(R)$ powered with SOPHiA DDM(TM) which has already attracted 34 customers since its launch in Q2, exciting opportunities in the U.S., and an impressive base of 92 new customers to onboard and expand over the course of the year."

Business Highlights

Expanding usage of SOPHiA DDM(TM) worldwide

   -- Performed a record 352,000 analyses in FY 2024, representing 11% 
      year-over-year volume growth, or 13% when excluding COVID-related volumes 
 
   -- Delivered strong analysis volume growth in FY 2024 in NORAM and APAC with 
      33% and 40% year-over-year growth, respectively 
 
   -- Reached 472 core genomics customers as of December 31, 2024, who use 
      SOPHiA DDM(TM) regularly to analyze cases of cancer and rare disease, up 
      from 450 customers at the end of Q4 2023 
 
   -- Completed implementation for a record 35 new customers during Q4, up from 
      an average of 19 new customers per quarter for the rest of 2024 

Landing new Clinical customers to fuel future platform growth

   -- Signed a record 92 new customers in FY 2024, including 31 new customers 
      in Q4 2024, who will implement SOPHiA DDM(TM) and begin generating 
      revenue over the next twelve months 
 
   -- Recently signed major new customers across geographies including M42 in 
      the United Arab Emirates who is adopting MSK-ACCESS(R) powered with 
      SOPHiA DDM(TM), Fundación Jiménez Díaz in Spain who is 
      adopting MSK-ACCESS(R) and MSK-IMPACT(R) powered with SOPHiA DDM(TM), and 
      Mount Sinai in the United States who is adopting HemOnc and Solid Tumor 
      applications 
 
   -- Entered into a collaboration with Genesis Healthcare Co., Japan's leading 
      private genetic testing research company, to accelerate access to genomic 
      testing, data, and AI analytics for the Japanese population and support 
      BioPharma companies with advanced research and market access 

Accelerating platform adoption with new applications

   -- Signed a total of 34 new customers to the Liquid Biopsy application 
      MSK-ACCESS(R) powered with SOPHiA DDM(TM) since its launch in Q2 2024 
 
   -- Completed implementation for a total of 15 MSK-ACCESS(R) customers who 
      will ramp up usage of the application over the course of 2025 
 
   -- Signed a total of 7 customers to MSK-IMPACT(R) powered with SOPHiA 
      DDM(TM) since the Solid Tumor application's launch in October 2024 
 
   -- Continued to drive significant demand for MSK-ACCESS(R) and 
      MSK-IMPACT(R) as the pipeline of ongoing discussions reached more than 60 
      identified opportunities going into 2025 

Continued driving strong business momentum in the U.S. market

   -- Delivered 23% year-over-year Clinical revenue growth in the U.S. in FY 
      2024, making the country one of the Company's largest and fastest growing 
      markets going into 2025 
 
   -- Recently signed Mount Sinai, one of the leading hospital systems in the 
      world based in New York City, who is adopting HemOnc and Solid Tumor 
      applications 
 
   -- Expanded our partnership with Mayo Clinic as the top-ranked hospital now 
      plans to adopt additional HemOnc applications 

Growing sustainably by maintaining an obsession with operational excellence

   -- Remained laser-focused on operational excellence and improved adjusted 
      operating loss by 23% year-over-year in Q4 2024 and 20% year-over-year in 
      FY 2024, while also strengthening commercial teams and maintaining 
      investments in high impact R&D 
 
   -- Expanded adjusted gross margin by 80bps year-over-year to 74.2% in Q4 
      2024 with ongoing, continuous improvements to data processing, compute, 
      and storage costs 
 
   -- The Company remains committed to profitable growth and expects to be 
      approaching adjusted EBITDA breakeven by the end of 2026 and crossing 
      over to positive adjusted EBITDA in the second half of 2027 

2025 Financial Outlook

Based on information as of today, SOPHiA GENETICS is providing the following guidance:

   -- Full-year revenue between $72 million and $76 million, representing 
      growth of approximately 10% to 17% compared to FY 2024 
 
   -- Adjusted EBITDA loss between $35 million and $39 million, compared to 
      $40.2 million in FY 2024 

Other than with respect to revenue, the Company only provides guidance on a non-IFRS basis. The Company does not provide a reconciliation of forward-looking adjusted gross margin (non-IFRS measure) to gross margin (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses that are necessary for such reconciliation. In addition, the Company does not provide a reconciliation of forward-looking adjusted operating loss (non-IFRS measure) to operating loss (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses and intangible assets, share-based compensation expenses, and non-cash portion of pensions paid in excess of actual contributions, that are necessary for such reconciliation. The Company does not provide reconciliation of forward-looking adjusted EBITDA (non-IFRS measure) to net loss (the most comparable IFRS measure) due to the inherent difficulty in forecasting and quantifying certain amounts that are necessary for such reconciliation, including income tax, depreciation, amortization, fair value adjustments on warrant obligations, and foreign exchange gain (losses), net. Therefore, the Company is not able to forecast on an IFRS basis with reasonable certainty all deductions needed in order to calculate projected net loss at this time.

Earnings Call and Webcast Information

SOPHiA GENETICS will host a conference call and live webcast to discuss the fourth quarter and full year 2024 results, and financial guidance for the full year 2025 on Tuesday, March 4, 2025, at 8:00 a.m. (08:00) Eastern Time / 2:00 p.m. (14:00) Central European Time. The call will be webcast live on the SOPHiA GENETICS Investor Relations website, ir.sophiagenetics.com. Additionally, an audio replay of the conference call will be available on the SOPHiA GENETICS website after its completion.

Non-IFRS Financial Measures

To provide investors with additional information regarding the company's financial results, SOPHiA GENETICS has disclosed here and elsewhere in this earnings release the following non-IFRS measures:

   -- Adjusted gross profit, which the company calculates as revenue minus cost 
      of revenue adjusted to exclude amortization of capitalized research and 
      development expenses; 
 
   -- Adjusted gross profit margin, which the company calculates as adjusted 
      gross profit as a percentage of revenue; 
 
   -- Adjusted operating loss, which the company calculates as operating loss 
      adjusted to exclude amortization of capitalized research and development 
      expenses, amortization of intangible assets, share-based compensation 
      expense, non-cash portion of pensions expense paid in excess of actual 
      contributions to match the actuarial expense, and costs associated with 
      corporate restructuring; 
 
   -- EBITDA, which the company calculates as loss for the year before 
      depreciation, amortization, interest income, interest expense, fair value 
      adjustments on warrant obligations, foreign exchange (losses) gains, net, 
      and income tax (expense) benefit; and 
 
   -- Adjusted EBITDA, which the company calculates as EBITDA adjusted to 
      exclude share-based compensation expense, non-cash pension expenses, and 
      costs associated with restructuring. 

These non-IFRS measures are key measures used by SOPHiA GENETICS management and board of directors to evaluate its operating performance and generate future operating plans. The exclusion of certain expenses facilitates operating performance comparability across reporting periods by removing the effect of non-cash expenses and certain variable charges. Accordingly, the company believes that these non-IFRS measures provide useful information to investors and others in understanding and evaluating its operating results in the same manner as its management and board of directors.

These non-IFRS measures have limitations as financial measures, and you should not consider them in isolation or as a substitute for analysis of SOPHiA GENETICS' results as reported under IFRS. Some of these limitations are:

   -- These non-IFRS measures exclude the impact of depreciation. Although 
      depreciation is a non-cash charge, the assets being depreciated may need 
      to be replaced in the future and these non-IFRS measures do not reflect 
      capital expenditure requirements for such replacements or for new capital 
      expenditures; 
 
   -- These non-IFRS measures exclude the impact of interest expense. Interest 
      expense will continue to be for the foreseeable future a recurring 
      expense based on the company's financial liabilities; 
 
   -- These non-IFRS measures exclude the impact of interest income. Interest 
      income will continue to be for the foreseeable future recurring income 
      based on the company's financial assets; 
 
   -- These non-IFRS measures exclude the impact of income taxes. Income taxes 
      will continue to be for the foreseeable future a recurring expense 
      incurred in the various jurisdictions in which the company operates; 
 
   -- These non-IFRS measures exclude the impact of foreign exchange gains 
      (losses),net. Foreign exchange gains and losses will continue to be for 
      the foreseeable future a recurring expense incurred as the company 
      participates in transactions outside of the company's functional 
      currency; 
 
   -- These non-IFRS measures exclude the impact of fair value adjustments of 
      warrant obligations. Fair value adjustments on warrant obligations will 
      continue to be for the foreseeable future a recurring expense incurred as 
      the company has outstanding warrant obligations; 
 
   -- These non-IFRS measures exclude the impact of amortization of capitalized 
      research and development expenses and intangible assets. Although 
      amortization is a non-cash charge, the assets being amortized may need to 
      be replaced in the future and these non-IFRS measures do not reflect 
      capital expenditure requirements for such replacements or for new capital 
      expenditures; 
 
   -- These non-IFRS measures exclude the impact of share-based compensation 
      expenses. Share-based compensation has been, and will continue to be for 
      the foreseeable future, a recurring expense in the company's business and 
      an important part of its compensation strategy; 
 
   -- These non-IFRS measures exclude the impact of the non-cash portion of 
      pensions paid in excess of actual contributions to match actuarial 
      expenses. Pension expenses have been, and will continue to be for the 
      foreseeable future, a recurring expense in the business; 
 
   -- These non-IFRS measures exclude the impact of costs associated with 
      corporate restructuring, which we may incur from time to time; and 
 
   -- Other companies, including companies in the company's industry, may 
      calculate these non-IFRS measures differently, which reduces their 
      usefulness as comparative measures. 

Because of these limitations, you should consider these non-IFRS measures alongside other financial performance measures, including various cash flow metrics, net income and other IFRS results.

The tables below provide the reconciliation of the most comparable IFRS measures to the non-IFRS measures for the periods presented.

Presentation of Constant Currency Revenue and Excluding COVID-19-Related Revenue

SOPHiA GENETICS operates internationally, and its revenues are generated primarily in the U.S. dollar, the euro and Swiss franc and, to a lesser extent, British pound, Australian dollar, Brazilian real, Turkish lira and Canadian dollar depending on the company's customers' geographic locations. Changes in revenue include the impact of changes in foreign currency exchange rates. We present the non-IFRS financial measure "constant currency revenue" (or similar terms such as constant currency revenue growth) to show changes in revenue without giving effect to period-to-period currency fluctuations. Under IFRS, revenues recorded in local (non-U.S. dollar) currencies are translated into U.S. dollars at the average monthly exchange rate for the month in which the transaction occurred. When the company uses the term "constant currency", it means that it has translated local currency revenues for the current reporting period into U.S. dollars using the same average foreign currency exchange rates for the conversion of revenues into U.S. dollars that we used to translate local currency revenues for the comparable reporting period of the prior year. The company then calculates the difference between the IFRS revenue and the constant currency revenue to yield the "constant currency impact" for the current period.

The company's management and board of directors use constant currency revenue growth to evaluate growth and generate future operating plans. The exclusion of the impact of exchange rate fluctuations provides comparability across reporting periods and reflects the effects of customer acquisition efforts and land-and-expand strategy. Accordingly, it believes that this non-IFRS measure provides useful information to investors and others in understanding and evaluating revenue growth in the same manner as the management and board of directors. However, this non-IFRS measure has limitations, particularly as the exchange rate effects that are eliminated could constitute a significant element of its revenue and could significantly impact performance and prospects. Because of these limitations, you should consider this non-IFRS measure alongside other financial performance measures, including revenue and revenue growth presented in accordance with IFRS and other IFRS results.

In addition to constant currency revenue, the company presents constant currency revenue excluding COVID-19-related revenue to further remove the effects of revenues that are derived from sales of COVID-19-related offerings, including a NGS assay for COVID-19 that leverages the SOPHiA DDM(TM) Platform and related products and solutions analytical capabilities and COVID-19 bundled access products. SOPHiA GENETICS do not believe that these revenues reflect its core business of commercializing its platform because the company's COVID-19 solution was offered to address specific market demand by its customers for analytical capabilities to assist with their testing operations. The company does not anticipate additional development of its COVID-19-related solution as the pandemic transitions into a more endemic phase and as customer demand continues to decline. Further, COVID-19-related revenues did not constitute, and the company does not expect COVID-19-related revenues to constitute in the future, a significant part of its revenue. Accordingly, the company believes that this non-IFRS measure provides useful information to investors and others in understanding and evaluating its revenue growth. However, this non-IFRS measure has limitations, including that COVID-19-related revenues contributed to the company's cash position, and other companies may define COVID-19-related revenues differently. Because of these limitations, you should consider this non-IFRS measure alongside other financial performance measures, including revenue and revenue growth presented in accordance with IFRS and other IFRS results.

The table below provides the reconciliation of the most comparable IFRS growth measures to the non-IFRS growth measures for the current period.

About SOPHiA GENETICS

SOPHiA GENETICS (Nasdaq: SOPH) is a cloud-native healthcare technology company on a mission to expand access to data-driven medicine by using AI to deliver world-class care to patients with cancer and rare disorders across the globe. It is the creator of SOPHiA DDM(TM), a platform that analyzes complex genomic and multimodal data and generates real-time, actionable insights for a broad global network of hospital, laboratory, and biopharma institutions. For more information, visit SOPHiAGENETICS.COM and connect with us on LinkedIn.

Forward-Looking Statements

This press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including 2023 guidance and statements regarding our future results of operations and financial position, business strategy, products and technology, partnerships, and collaborations, as well as plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements are based on our management's beliefs and assumptions and on information currently available to our management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including those described in our filings with the U.S. Securities and Exchange Commission. No assurance can be given that such future results will be achieved. Such forward-looking statements contained in this document speak only as of the date of this press release. We expressly disclaim any obligation or undertaking to update these forward-looking statements contained in this press release to reflect any change in our expectations or any change in events, conditions, or circumstances on

which such statements are based, unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.

 
                          SOPHiA GENETICS SA 
                    Consolidated Statement of Loss 
           (Amounts in USD thousands, except per share data) 
                              (Unaudited) 
 
                       Three months ended            Year ended 
                          December 31,              December 31, 
                    ------------------------  ------------------------ 
                       2024         2023         2024         2023 
                    -----------  -----------  -----------  ----------- 
Revenue               $  17,733    $  17,048    $  65,173    $  62,371 
Cost of revenue         (5,631)      (5,150)     (21,236)     (19,458) 
                    -----------  -----------  -----------  ----------- 
Gross profit             12,102       11,898       43,937       42,913 
                    -----------  -----------  -----------  ----------- 
Research and 
 development 
 costs                  (9,143)      (9,759)     (34,366)     (36,969) 
Selling and 
 marketing costs        (7,854)      (7,966)     (29,369)     (28,423) 
General and 
 administrative 
 costs                 (12,665)     (13,269)     (46,953)     (53,301) 
Other operating 
 income, net                116          150          183          954 
                    -----------  -----------  -----------  ----------- 
Operating loss         (17,444)     (18,946)     (66,568)     (74,826) 
                    -----------  -----------  -----------  ----------- 
Interest income             655          961        3,362        4,547 
Interest expense          (681)        (150)      (1,913)        $(588.SI)$ 
Fair value 
 adjustments on 
 warrant 
 obligations                104           --          370           -- 
Foreign exchange 
 gains (losses), 
 net                      2,824      (5,917)        3,479      (7,628) 
                    -----------  -----------  -----------  ----------- 
Loss before income 
 taxes                 (14,542)     (24,052)     (61,270)     (78,495) 
                    -----------  -----------  -----------  ----------- 
Income tax expense        (616)          (8)      (1,223)        (486) 
                    -----------  -----------  -----------  ----------- 
Loss for the 
 period                (15,158)     (24,060)     (62,493)     (78,981) 
                    -----------  -----------  -----------  ----------- 
Attributable to 
 the owners of the 
 parent                (15,158)     (24,060)     (62,493)     (78,981) 
                    -----------  -----------  -----------  ----------- 
 
Basic and diluted 
 loss per share     $    (0.23)  $    (0.37)  $    (0.95)  $    (1.22) 
                    ===========  ===========  ===========  =========== 
 
 
                          SOPHiA GENETICS SA 
             Consolidated Statement of Comprehensive Loss 
                      (Amounts in USD thousands) 
                              (Unaudited) 
 
                          Three months ended          Year ended 
                             December 31,            December 31, 
                        ----------------------  ---------------------- 
                           2024        2023        2024        2023 
                        ----------  ----------  ----------  ---------- 
Loss for the period     $ (15,158)  $ (24,060)  $ (62,493)  $ (78,981) 
Other comprehensive 
(loss) income: 
   Items that may be 
   reclassified to 
   statement of loss 
   Currency 
    translation 
    adjustments            (7,530)     (3,382)     (9,679)      15,037 
                        ----------  ----------  ----------  ---------- 
Total items that may 
 be reclassified to 
 statement of loss         (7,530)     (3,382)     (9,679)      15,037 
   Items that will 
   not be 
   reclassified to 
   statement of loss 
   (net of tax) 
   Remeasurement of 
    defined benefit 
    plans                      558          71         327       (212) 
                        ----------  ----------  ----------  ---------- 
Total items that will 
 not be reclassified 
 to statement of loss          558          71         327       (212) 
Other comprehensive 
 (loss) income for the 
 period                 $  (6,972)  $  (3,311)  $  (9,352)   $  14,825 
                        ==========  ==========  ==========  ========== 
Total comprehensive 
 loss for the period    $ (22,130)  $ (27,371)  $ (71,845)  $ (64,156) 
                        ==========  ==========  ==========  ========== 
Attributable to owners 
 of the parent          $ (22,130)  $ (27,371)  $ (71,845)  $ (64,156) 
                        ==========  ==========  ==========  ========== 
 
 
                            SOPHiA GENETICS SA 
                        Consolidated Balance Sheet 
                        (Amounts in USD thousands) 
                                (Unaudited) 
 
                                         December 31, 
                               2024                        2023 
                    --------------------------  -------------------------- 
Assets 
Current assets 
 Cash and cash 
  equivalents        $                  80,226    $                123,251 
 Accounts 
  receivable                             7,436                      13,557 
 Inventory                               5,868                       6,482 
 Prepaids and 
  other current 
  assets                                 5,875                       4,757 
                    --------------------------  -------------------------- 
Total current 
 assets                                 99,405                     148,047 
                    --------------------------  -------------------------- 
Non-current 
assets 
 Property and 
  equipment                              5,209                       7,469 
 Intangible assets                      28,998                      27,185 
 Right-of-use 
  assets                                14,168                      15,635 
 Deferred tax 
  assets                                 1,767                       1,720 
 Other non-current 
  assets                                 5,762                       6,100 
                    --------------------------  -------------------------- 
Total non-current 
 assets                                 55,904                      58,109 
                    --------------------------  -------------------------- 
Total assets          $                155,309    $                206,156 
                    ==========================  ========================== 
Liabilities and 
equity 
Current 
liabilities 
 Accounts payable   $                    5,220  $                    5,391 
 Accrued expenses                       13,217                      17,808 
 Deferred contract 
  revenue                                5,732                       9,494 
 Lease 
  liabilities, 
  current portion                        2,190                       2,928 
 Warrant 
 obligations                               444                          -- 
Total current 
 liabilities                            26,803                      35,621 
                    --------------------------  -------------------------- 
Non-current 
liabilities 
 Borrowings                             13,237                          -- 
 Lease 
  liabilities, net 
  of current 
  portion                               14,603                      15,673 
 Defined benefit 
  pension 
  liabilities                            3,839                       3,086 
 Other non-current 
  liabilities                              337                         334 
                    --------------------------  -------------------------- 
Total non-current 
 liabilities                            32,016                      19,093 
                    --------------------------  -------------------------- 
Total liabilities                       58,819                      54,714 
                    --------------------------  -------------------------- 
Equity 
 Share capital                           4,188                       4,048 
 Share premium                         472,244                     471,846 
 Treasury shares                         (702)                       (646) 
 Other reserves                         61,037                      53,978 
 Accumulated 
  deficit                            (440,277)                   (377,784) 
                    --------------------------  -------------------------- 
Total equity                            96,490                     151,442 
                    --------------------------  -------------------------- 
Total liabilities 
 and equity           $                155,309    $                206,156 
                    ==========================  ========================== 
 
 
                            SOPHiA GENETICS SA 
                   Consolidated Statement of Cash Flows 
                        (Amounts in USD thousands) 
                                (Unaudited) 
 
                                                          Year ended 
                                                         December 31, 
                                                    ---------------------- 
                                                       2024        2023 
                                                    ----------  ---------- 
Operating activities 
Loss before tax                                     $ (61,270)  $ (78,495) 
Adjustments for non-monetary items 
Depreciation                                             4,575       5,508 
Amortization                                             4,021       2,828 
Finance (income) expense, net                          (5,210)       2,934 
Interest expense from borrowings                            --          -- 
Fair value adjustments on warrant obligations            (370)          -- 
Expected credit loss allowance                           (523)         214 
Share-based compensation                                16,488      15,242 
Intangible assets write-off                                 --          -- 
Movements in provisions and pensions                     1,617         308 
Research tax credit                                      (726)     (1,129) 
Loss on disposal of property and equipment                  --          28 
Gain on disposal of lease liability                         --       (733) 
Working capital changes 
Decrease (Increase) in accounts receivable               5,892     (6,500) 
(Increase) decrease in prepaids and other assets       (1,157)       1,375 
Decrease (Increase) in inventory                            69       (874) 
(Decrease) Increase in accounts payables, accrued 
 expenses, deferred contract revenue, and other 
 liabilities                                           (7,385)       6,871 
                                                    ----------  ---------- 
Cash used in operating activities                     (43,979)    (52,423) 
                                                    ----------  ---------- 
Income tax paid                                          (536)       (801) 
Interest paid                                          (1,728)         (6) 
Interest received                                        3,421       4,655 
                                                    ----------  ---------- 
Net cash flows used in operating activities           (42,822)    (48,575) 
                                                    ----------  ---------- 
Investing activities 
Purchase of property and equipment                       (244)     (1,494) 
Acquisition of intangible assets                         (195)       (263) 
Capitalized development costs                          (7,737)     (7,469) 
Proceeds upon maturity of term deposits                     --      17,546 
Purchase of term deposits                                   --          -- 
                                                    ----------  ---------- 
Net cash flow (used in) provided from investing 
 activities                                            (8,176)       8,320 
                                                    ----------  ---------- 
Financing activities 
Proceeds from exercise of share options                    405         226 
Proceeds from borrowings, net of transaction 
costs                                                   13,930          -- 
Capitalized borrowing transaction costs                     --          -- 
Payments of principal portion of lease liabilities     (2,750)     (3,043) 
                                                    ----------  ---------- 
Net cash flow provided from (used in) financing 
 activities                                             11,585     (2,817) 
                                                    ----------  ---------- 
Decrease in cash and cash equivalents                 (39,413)    (43,072) 
                                                    ----------  ---------- 
Effect of exchange differences on cash balances        (3,612)       5,018 
Cash and cash equivalents at beginning of the year     123,251     161,305 
                                                    ----------  ---------- 
Cash and cash equivalents at end of the year         $  80,226   $ 123,251 
                                                    ==========  ========== 
 
 
                                        SOPHiA GENETICS SA 
                   Reconciliation of IFRS Net Loss to EBITDA and Adjusted EBITDA 
                                    (Amounts in USD thousands) 
                                            (Unaudited) 
 
                              Three months ended 
                                 December 31,                      Year ended December 31, 
                    --------------------------------------  -------------------------------------- 
                           2024                2023                2024                2023 
Loss for the 
 period             $         (15,158)  $         (24,060)  $         (62,493)  $         (78,981) 
Exclude the 
impact of: 
Depreciation        $            1,136  $            1,170  $            4,575  $            6,030 
Amortization                     1,152                 811               4,021               2,828 
Interest income                  (655)               (961)             (3,362)             (4,547) 
Interest expense                   681                 150               1,913                 588 
Fair value 
 adjustments on 
 warrant 
 obligations                     (104)                  --               (370)                  -- 
Foreign exchange 
 gains (losses), 
 net                           (2,824)               5,917             (3,479)               7,628 
Income tax expense                 616                   8               1,223                 486 
                    ------------------  ------------------  ------------------  ------------------ 
EBITDA              $         (15,156)  $         (16,965)  $         (57,972)  $         (65,968) 
Adjustments to 
EBITDA: 
Share-based 
 compensation 
 expense(1)                      5,078               4,211              16,488              15,247 
Non-cash pension 
 expenses 
 (income)(2)                     1,027               (625)               1,306               (394) 
Costs associated 
 with 
 restructuring(3)                   --               1,232                  --               1,232 
                    ------------------  ------------------  ------------------  ------------------ 
Adjusted EBITDA     $          (9,051)  $         (12,147)  $         (40,178)  $         (49,883) 
 
 
                              SOPHiA GENETICS SA 
   Reconciliation of IFRS Revenue Growth to Constant Currency Revenue Growth 
    and Constant Currency Revenue Growth Excluding COVID-19-Related Revenue 
                    (Amounts in USD thousands, expect for %) 
                                  (Unaudited) 
 
                          Three months ended 
                             December 31,            Year ended December 31, 
                     ----------------------------  ---------------------------- 
                       2024       2023     Growth    2024       2023     Growth 
                     ---------  ---------  ------  ---------  ---------  ------ 
IFRS revenue         $  17,733  $  17,048     4 %  $  65,173  $  62,371     4 % 
 Current period 
  constant currency 
  impact                   192         --                129         -- 
                     ---------  ---------  ------  ---------  ---------  ------ 
Constant currency 
 revenue             $  17,925  $  17,048     5 %  $  65,302  $  62,371     5 % 
 COVID-19-related 
  revenue                 (35)      (106)               (78)      (319) 
 Constant currency 
 impact on 
 COVID-19-related 
 revenue                   (2)         --                 --         -- 
                     ---------  ---------  ------  ---------  ---------  ------ 
Constant currency 
 revenue excluding 
 COVID-19-related 
 revenue             $  17,888  $  16,942     6 %  $  65,224  $  62,052     5 % 
                     =========  =========  ======  =========  =========  ====== 
 
 
SOPHiA GENETICS SA Reconciliation of IFRS to Adjusted Gross Profit and 
  Gross Profit Margin (Amounts in USD thousands, except percentages) 
                             (Unaudited) 
 
                        Three months ended 
                           December 31,       Year ended December 31, 
                       --------------------  ------------------------- 
                         2024       2023         2024         2023 
                       ---------  ---------  ------------  ----------- 
Revenue                 $ 17,733   $ 17,048      $ 65,173     $ 62,371 
 Cost of revenue         (5,631)    (5,150)      (21,236)     (19,458) 
                       ---------  ---------  ------------  ----------- 
Gross profit            $ 12,102   $ 11,898      $ 43,937     $ 42,913 
 Amortization of 
  capitalized 
  research and 
  development 
  expenses(4)              1,061        619         3,524        2,099 
Adjusted gross profit   $ 13,163   $ 12,517      $ 47,461     $ 45,012 
                       =========  =========  ============  =========== 
 
Gross profit margin       68.2 %     69.8 %        67.4 %       68.8 % 
 Amortization of 
  capitalized 
  research and 
  development 
  expenses(4)              6.0 %      3.6 %         5.4 %        3.4 % 
Adjusted gross profit 
 margin                   74.2 %     73.4 %        72.8 %       72.2 % 
 
 
                          SOPHiA GENETICS SA 
           Reconciliation of IFRS to Adjusted Operating Loss 
                      (Amounts in USD thousands) 
                              (Unaudited) 
 
                          Three months ended          Year ended 
                             December 31,            December 31, 
                        ----------------------  ---------------------- 
                           2024        2023        2024        2023 
                        ----------  ----------  ----------  ---------- 
Operating loss          $ (17,444)  $ (18,946)  $ (66,568)  $ (74,826) 
 Amortization of 
  capitalized research 
  & development 
  expenses(4)                1,061         619       3,524       2,099 
 Amortization of 
  intangible 
  assets(5)                     90         193         497         729 
 Share-based 
  compensation 
  expense(1)                 5,078       4,211      16,488      15,247 
 Non-cash pension 
  expense(2)                 1,027       (625)       1,306       (394) 
 Costs associated with 
  restructuring(3)              --       1,232          --       1,232 
                        ----------  ----------  ----------  ---------- 
Adjusted operating 
 loss                   $ (10,188)  $ (13,316)  $ (44,753)  $ (55,913) 
                        ==========  ==========  ==========  ========== 
 
 

(MORE TO FOLLOW) Dow Jones Newswires

March 04, 2025 06:45 ET (11:45 GMT)

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