On March 7, 2025, Vertex Pharmaceuticals announced that its cystic fibrosis treatment, ALYFTREK®, had received regulatory approval from the UK's MHRA, a significant milestone in expanding its market presence. This announcement, alongside FDA approval in December 2024, likely bolstered the company's recent stock performance. Over the last quarter, Vertex's share price increased by 5.11%, despite broader market challenges, including economic slowdown concerns and significant market index declines—such as a 3.6% drop in the S&P 500. Meanwhile, Vertex's strategic maneuvers, including collaborations to ensure patient access to treatments, and notable product-related successes, likely provided a counterbalancing effect to market volatility and sentiment. Amid a generally declining market trend over the last week, this resilience reflects investor confidence, aided by Vertex's continuous focus on innovative treatments and expanding patient reach for its therapies, thus securing noteworthy returns amid broader market headwinds.

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The last five years have seen Vertex Pharmaceuticals deliver a total return of 138.03%, underscoring its substantial growth despite broader market challenges. Vertex's performance outpaced the broader biotech industry, as evidenced by its recent gains against industry benchmarks. Several impactful developments have played a crucial role in this performance. A major highlight was the FDA's 2023 approval of CASGEVY™, the first CRISPR/Cas9 therapy for sickle cell disease, marking a significant milestone in genetic therapy. The launch of JOURNAVX, approved in January 2025, diversified Vertex's portfolio with a non-opioid pain management solution.

Complementing these approvals, strategic moves like Vertex's 2024 partnership with Zai Lab Limited expanded its presence in Asia, enhancing its global footprint. Another factor was a robust buyback program, culminating in a US$1.62 billion repurchase of shares, reinforcing shareholder value. Looking to the future, Vertex's raised revenue guidance for 2025, driven by the ALYFTREK® launch, continues to paint an optimistic growth trajectory.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

Companies discussed in this article include NasdaqGS:VRTX.

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