Radiopharm Theranostics (ASX:RAD) said that data presented at the most recent European Molecular Imaging Meeting confirmed positive tumor uptake and favorable biodistribution for RAD202, according to a Monday filing with the Australian bourse.
The human epidermal growth factor receptor 2 or, HER2, is overexpressed in breast cancer as well as several other solid tumors and represents a validated target in oncology. RAD202 is a proprietary single-domain antibody that targets HER2.
The imaging data reported that gallium-68-RAD202 binds specifically to the receptor in HER2-positive xenografts, with a high tumor-to-background ratio. Imaging with it resulted in specific accumulation in the tumor and low uptake in non-target organs, except for the bladder and kidney.
The removal of a polyhistidine tag from the RAD202 nanobody, which impacts biodistribution and tumor targeting, was validated to be superior for positron emission tomography imaging due to the higher tumor-to-organ ratio.
Therapy with lutetium-177-RAD202 was well-tolerated, confirming a reduction in tumor volume, significantly prolonging survival time.
A dose escalation phase one study of lutetium-177-RAD202 is currently in the recruiting phase in Australia. It is designed to evaluate the safety and preliminary activity of the radiotherapeutic product in patients with advanced HER2-positive solid tumors.
Its shares jumped 11% on market close on Monday.
免責聲明:投資有風險,本文並非投資建議,以上內容不應被視為任何金融產品的購買或出售要約、建議或邀請,作者或其他用戶的任何相關討論、評論或帖子也不應被視為此類內容。本文僅供一般參考,不考慮您的個人投資目標、財務狀況或需求。TTM對信息的準確性和完整性不承擔任何責任或保證,投資者應自行研究並在投資前尋求專業建議。