Nyrada Inc (ASX:NYR) has reported strong results from a collaborative study into traumatic brain injury at the University of Sydney, in which its lead drug candidate NYR-BI03 showed neuroprotective effectiveness.

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Nyrada is working with the Walter Reed Army Institute of Research and the University of New South Wales on the project, which revealed that NYR-BI03 could prevent secondary brain injury following a penetrating traumatic brain injury.

This was confirmed through MRI imaging conducted at the university, which confirmed statistically significant neuroprotection (p = 0.043) for NYR-BI03.

WRAIR – a globally significant military medical research institution that is part of theU.S. Army – provided an established penetrating TBI model involving 28 test animals,which received continuous intravenous infusion of either NYR-BI03 or a vehicle control, over48 hours.

Chair of the Scientific Advisory Board (SAB) and UNSW Scientia Professor Gary Housley said these results were significant. “This study provides strong evidence that Nyrada’s NYR-BI03 drug protected the brain following severe TBI.”

“This was determined using a new MRI approach for quantifying brain tissue integrity.”

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At the same time, Nyrada is progressing NYR-BI03 – a first-in-class TRPC 3/6/7 blocker with a novel mechanism of action – through a Phase I clinical trial to assess its safety and tolerability.

Readouts are expected in the third quarter of the 2025 calendar year.

Nyrada shares have been trading at 9.3 cents.

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