Johnson & Johnson's New 'Compelling Data' Shows Sustained Symptom Improvement In Muscular Disease Patients

Benzinga
04-09

Johnson & Johnson (NYSE:JNJ) on Tuesday announced results from additional analyses of the Phase 3 Vivacity-MG3 study and the ongoing open-label extension (OLE), evaluating the long-term efficacy and safety of nipocalimab in a broad population of antibody-positive adults with generalized myasthenia gravis (gMG).

Patients treated with nipocalimab plus standard of care (SOC) maintained improvements in their MG-ADL (activities of daily living) and QMG (quantifies disease severity) scores over 84 weeks with sustained reductions in total immunoglobulin G (IgG).

Nipocalimab demonstrated a mean change in MG-ADL of -5.64 (p<0.001) after 60 weeks in the OLE for study participants receiving nipocalimab and SOC, and -6.01 (p<0.001) mean change for study participants who transitioned from placebo and SOC to nipocalimab and SOC.

Also Read: Johnson & Johnson’s Tremfya Shows Efficacy In Late-Stage Psoriatic Arthritis Study

In the antibody-positive population, 45% of patients receiving steroids at the OLE baseline were able to decrease or discontinue steroids at the time of this data cut by more than half of the baseline dose.

  • Among these patients, the mean dose of prednisone decreased from 23 to 10 mg daily.

Nipocalimab had a consistent and tolerable safety profile throughout the OLE phase.

Additional findings from the Phase 3 Vivacity-MG3 study indicate that patients treated with nipocalimab plus SOC achieved statistically significant improvements in their QMG score by -4.9 versus placebo plus SOC (p<0.001) over weeks 22 and 24.

Patients in the nipocalimab plus SOC treatment group were four times more likely to sustain symptom improvement at 20 weeks than the placebo plus SOC group, as measured by a three- or greater-point improvement on the QMG score.

Results show significantly more patients treated with nipocalimab (36.4%) versus placebo (10.5%, p<0.001) spent greater than 75% of the study duration, demonstrating improvements in the QMG score.

A reduction of more than three points in the QMG score indicates a decrease in the severity of the patient’s symptoms due to improvements in muscle strength, allowing patients to carry out important daily activities such as swallowing and chewing.

Price Action: JNJ stock is down 0.21% at $150.31 at the last check on Tuesday.

Read Next:

  • Amazon Touts AI Milestone, Says New Model Outshines GPT-4o In Real-Time Speech

Image via Shutterstock

UNLOCKED: 5 NEW TRADES EVERY WEEK. Click now to get top trade ideas daily, plus unlimited access to cutting-edge tools and strategies to gain an edge in the markets.

Get the latest stock analysis from Benzinga?

  • JOHNSON & JOHNSON (JNJ): Free Stock Analysis Report

This article Johnson & Johnson's New 'Compelling Data' Shows Sustained Symptom Improvement In Muscular Disease Patients originally appeared on Benzinga.com

© 2025 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

免責聲明:投資有風險,本文並非投資建議,以上內容不應被視為任何金融產品的購買或出售要約、建議或邀請,作者或其他用戶的任何相關討論、評論或帖子也不應被視為此類內容。本文僅供一般參考,不考慮您的個人投資目標、財務狀況或需求。TTM對信息的準確性和完整性不承擔任何責任或保證,投資者應自行研究並在投資前尋求專業建議。

熱議股票

  1. 1
     
     
     
     
  2. 2
     
     
     
     
  3. 3
     
     
     
     
  4. 4
     
     
     
     
  5. 5
     
     
     
     
  6. 6
     
     
     
     
  7. 7
     
     
     
     
  8. 8
     
     
     
     
  9. 9
     
     
     
     
  10. 10