智通财经APP获悉，百时美施贵宝(BMY.US)公布EMERGENT-4和EMERGENT-5开放标签临床3期试验的最新顶线结果。分析显示，精神分裂症成人患者在接受Cobenfy(xanomeline and trospium chloride，即KarXT)口服胶囊治疗达52周时其症状持续改善，表明疗效得以维持。值得一提的是，Cobenfy在今年初被行业媒体Evaluate评选为2024有望获批的10款潜在重磅疗法之一。
公开资料显示，Cobenfy由xanomeline和trospium chloride两种有效成分构成，旨在激活大脑中的毒蕈碱型乙酰胆碱受体的同时，减少对外周毒蕈碱型乙酰胆碱受体的作用。通过刺激毒蕈碱受体M1和M4受体，xanomeline可缓解负面症状，如冷漠、社会驱动力减少、提高认知能力，并对改善其它精神症状，如幻觉和妄想很有帮助。而季铵盐化合物trospium chloride为毒蕈碱受体拮抗剂，可抑制xanomeline于外周神经中的副作用。
据悉，美国FDA在今年9月批准Cobenfy口服胶囊用于治疗精神分裂症成人患者。FDA新闻稿指出，这是靶向胆碱能受体的首个抗精神病药物(antipsychotic drug)，长期以来精神分裂症的标准疗法靶向多巴胺受体。该疗法也标志着过去数十年来首个治疗精神分裂症的新机制药物。
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