智通财经APP获悉，11月6日，CDE网站显示，艾伯维(ABBV.US)的CD3/CD20双抗艾可瑞妥单抗(epcoritamab，美国商品名：Epkinly)在中国申报上市。

艾可瑞妥单抗是由Genmab利用其专有的DuoBody技术开发的一款IgG1双特异性抗体，可同时靶向T细胞上的CD3和B细胞上的CD20，诱导T细胞杀伤CD20+细胞。2020年6月，艾伯维与Genmab达成协议，共同开发和商业化包括该产品在内的3款双抗。

艾可瑞妥单抗的作用机制(来源：艾伯维官网)

在EPCORE NHL-1研究中，DLBCL患者(n=148)接受艾可瑞妥单抗治疗后，总体缓解率(ORR)为61%，完全缓解率(CR)为38%，中位缓解持续时间(mDOR)为15.6个月;FL患者(n=128)接受艾可瑞妥单抗治疗后，ORR为82%，mDOR尚未达到，DOR达到12个月的患者比例为68.4%。

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