晨泰医药/阿斯利康(AZN.US)可透脑EGFR抑制剂“佐利替尼”获批上市

智通财经
20 Nov 2024

智通财经APP获悉,11月20日,国家药监局官网显示,晨泰医药与阿斯利康(AZN.US)合作开发的EGFR抑制剂佐利替尼(zorifertinib/AZD3759)获批上市,用于具有表皮生长因子受体(EGFR)19号外显子缺失或外显子21(L858R)置换突变,并伴中枢神经系统(CNS)转移的局部晚期或转移性非小细胞肺癌(NSCLC)成人患者的一线治疗。

EGFR普遍表达于人体表皮细胞和基质细胞,并在多种人类恶性肿瘤中存在高表达,如非小细胞肺癌。EGFR基因突变时将造成细胞膜表面的表皮生长因子受体过多,加速促进细胞异常生长和分裂,最终导致肿瘤发生。

佐利替尼是一种有效的、口服的、可逆的表皮生长因子受体激活突变(L858R和Exon 19Del)酪氨酸激酶活性抑制剂(EGFR-TKI),专为治疗晚期非小细胞肺癌伴中枢神经系统转移患者设计。临床前和早期临床数据显示,佐利替尼具有高达100%的血脑屏障透过率。

Disclaimer: Investing carries risk. This is not financial advice. The above content should not be regarded as an offer, recommendation, or solicitation on acquiring or disposing of any financial products, any associated discussions, comments, or posts by author or other users should not be considered as such either. It is solely for general information purpose only, which does not consider your own investment objectives, financial situations or needs. TTM assumes no responsibility or warranty for the accuracy and completeness of the information, investors should do their own research and may seek professional advice before investing.

Most Discussed

  1. 1
     
     
     
     
  2. 2
     
     
     
     
  3. 3
     
     
     
     
  4. 4
     
     
     
     
  5. 5
     
     
     
     
  6. 6
     
     
     
     
  7. 7
     
     
     
     
  8. 8
     
     
     
     
  9. 9
     
     
     
     
  10. 10