智通财经APP获悉，葛兰素史克(GSK.US)报告称，一项研究表明，其药物 belantamab mafodotin 能够将多发性骨髓瘤患者在首次复发时或复发后的死亡风险降低 42%。
该研究正在评估 belantamab mafodotin 与 bortezomib plus dexamethasone(BVd)联合治疗与 daratumumab 与 bortezomib plus dexamethasone(DVd)联合治疗作为复发或难治性多发性骨髓瘤的二线或后续治疗。
该研究的计划中期分析(称为 DREAMM-7)显示，与基于daratumumab单抗的对照相比，接受belantamab mafodotin联合治疗的患者的死亡风险显著降低了42%，具有统计学意义。中位随访时间为39.4个月。
葛兰素史克补充说，尽管两个研究组的中位总生存期 (mOS) 均未达到，但根据一份声明，BVd 的预计 mOS 为 84 个月，而 DVd 的预计 mOS 为 51 个月。
这家英国制药商还表示，belantamab mafodotin 组合在微小残留病阴性这一关键次要终点上表现出统计学上的显著优势。
该数据是在圣地亚哥举行的美国血液学会年会上公布的。
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