智通财经APP获悉，阿斯利康(AZN.US)和默沙东(MRK.US)今日公布了3期临床试验OlympiA的长期结果。研究显示，PARP抑制剂Lynparza(olaparib，奥拉帕利)在携带种系BRCA突变(gBRCAm)的HER2阴性高危早期乳腺癌患者中持续显著改善患者的总生存期(OS)、无侵袭性疾病生存期(IDFS)和无远处疾病生存期(DDFS)。
在中位随访时间达6.1年时，在已完成局部治疗及标准新辅助或辅助化疗的患者中，Lynparza与安慰剂相比，将死亡风险降低了28%（HR＝0.72；95% CI：0.56-0.93）。此外，接受Lynparza治疗的患者中87.5%仍然存活，而安慰剂组这一数值为83.2%。
Lynparza则是一种“first-in-class"的PARP抑制剂，也是首个合成致死靶向治疗药物，用于靶向带有同源重组修复(HRR)缺陷的细胞/肿瘤(如携带BRCA1和/或BRCA2突变的细胞)。基于3期临床试验OlympiA的结果，Lynparza已在美国、欧盟、日本及许多其他国家和地区获批，用于治疗gBRCAm、HER2阴性高危早期乳腺癌。此外，它还获批在美国、欧盟、日本及许多其他国家和地区用于治疗gBRCAm、HER2阴性转移性乳腺癌。
Disclaimer: Investing carries risk. This is not financial advice. The above content should not be regarded as an offer, recommendation, or solicitation on acquiring or disposing of any financial products, any associated discussions, comments, or posts by author or other users should not be considered as such either. It is solely for general information purpose only, which does not consider your own investment objectives, financial situations or needs. TTM assumes no responsibility or warranty for the accuracy and completeness of the information, investors should do their own research and may seek professional advice before investing.