智通财经APP获悉,12月19日,中国国家药监局药品审评中心(CDE)官网公示,阿斯利康(AZN.US)1类新药AZD6234注射液获批临床,拟开发用于在至少有一种肥胖相关合并症的超重或者肥胖成年人中长期体重管理。公开资料显示,AZD6234是一款多肽类药物,为每周一次皮下注射的长效胰淀素受体激动剂。该产品正在国际范围内进行2b期临床研究,阿斯利康拟开发该产品作为肠促胰岛素不耐受肥胖患者的替代治疗方案。
截图来源:CDE官网
胰淀素(amylin)是GLP-1信号通路以外,另一种与饥饿和饱腹感相关的激素。胰淀素能够减少能量摄入,调节食物选择和偏好,其与胰岛素共同分泌而发挥葡萄糖调节作用,抑制餐后胰高血糖素释放,并延迟胃排空。研究表明,胰淀素受体激动剂可以通过减少脂肪量同时保持瘦体重(lean mass)来促进体重减轻,其还有望与GLP-1受体激动剂产生协同作用。
根据阿斯利康公开资料介绍,AZD6234是一种有效的胰淀素受体激动剂,对降钙素受体活性具有选择性。
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