和黄医药“赛沃替尼”拟纳入突破性疗法

医药魔方Info
23 Dec 2024

12月20日,CDE网站显示,和黄医药的赛沃替尼片拟纳入突破性疗法,拟定适应症为:赛沃替尼联合奥希替尼治疗经EGFR-TKI治疗失败伴MET扩增的局部晚期或转移性非小细胞肺癌。赛沃替尼(savolitinib,商品名:沃瑞沙)是一种口服的高选择性小分子c-Met抑制剂,可阻断因突变 (例如外显子14跳跃突变或其他点突变) 、基因扩增或蛋白质过表达而导致的MET受体酪氨酸激酶信号通路的异常激活。该药...

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