局灶节段性肾小球硬化(FSGS)是APOL1介导的慢性肾病的一种类型。遗传性功能增益性(gain of function)APOL1基因突变产生的蛋白会导致足细胞损伤。这种损伤破坏了肾脏正常的过滤功能，导致蛋白尿和快速进展的肾脏疾病。足细胞损伤与多种肾小球疾病密切相关，包括FSGS以及微小病变型肾病(MCD)等。
本次SAR442970注射液在中国获批临床，意味着该产品即将在中国进入临床研究阶段。
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