金吾财讯 | 强生(JNJ)公布,美国食品药品监督管理局 (FDA) 已授予 posdinemab 快速通道资格,posdinemab 是一种针对磷酸化 tau 的单克隆抗体 (mAb),正在2b期“AuTonomy”研究中研究用于治疗早期阿尔茨海默病 (AD) 患者。内部发现的 mAb 已显示出针对接受治疗的 AD 患者脑脊液 (CSF) 中与疾病相关的磷酸化 tau 的潜力,并可阻止非临床疾病模型中 tau 聚集体的形成和扩散。
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