1月22日，强生公司今日宣布，欧盟委员会已批准Lazcluze（lazertinib）与Rybrevant（amivantamab）联用，一线治疗携带表皮生长因子受体（EGFR）第19号外显子缺失（ex19del）或第21号外显子L858R突变的晚期非小细胞肺癌（NSCLC）成年患者。欧盟委员会的批准基于3期临床试验MARIPOSA的结果。该研究评估了Lazcluze联合Rybrevant，与活性对照osimertinib相比，一线治疗携带上述EGFR变异的NSCLC患者的疗效。分析显示，Rybrevant与Lazcluze联用，与活性对照药物相比，可将疾病进展或死亡风险降低30%。
联合疗法与活性对照药物组患者的中位无进展生存期（PFS）分别为23.7个月与16.6个月。此外，联合疗法组的中位缓解持续时间（DOR）比活性对照药物长9个月（25.8个月比16.7个月）。2025年1月7日，强生公司宣布了积极的总生存期（OS）顶线结果，显示Lazcluze联合Rybrevant达到了预先设定的次要终点，与现有标准治疗相比，为OS提供了统计显著并具有临床意义的改善。这些具有里程碑意义的OS数据将于即将召开的医学会议上发布。
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