【中方领衔团队破解辐射损伤细胞机制 有望优化放疗防护】辐射可造成DNA损伤,进而导致细胞死亡等。中国科学家13日在英国《细胞死亡和分化》期刊上发表的新研究揭示了STING(干扰素基因刺激因子)蛋白通过结合DNA损伤响应蛋白PARP1合成的产物分子PAR(多聚二磷酸腺苷核糖),驱动辐射后细胞死亡的关键机制。动物实验表明,阻断或抑制该通路可使小鼠肠道辐射损伤降低70%,生存率提升5倍。这一发现为癌症放疗副作用防护和急性辐射损伤救治提供了全新策略。

金融界
15 Feb
辐射可造成DNA损伤,进而导致细胞死亡等。中国科学家13日在英国《细胞死亡和分化》期刊上发表的新研究揭示了STING(干扰素基因刺激因子)蛋白通过结合DNA损伤响应蛋白PARP1合成的产物分子PAR(多聚二磷酸腺苷核糖),驱动辐射后细胞死亡的关键机制。动物实验表明,阻断或抑制该通路可使小鼠肠道辐射损伤降低70%,生存率提升5倍。这一发现为癌症放疗副作用防护和急性辐射损伤救治提供了全新策略。

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