Wall Street's main indexes moved lower on Friday, as investors assessed latest economic data including a weak consumer sentiment reading, while the blue-chip Dow suffered its steepest loss on a drag by UnitedHealth. .N

At 10:30 EST, the Dow Jones Industrial Average .DJI was down 0.86% at 43,796.80. The S&P 500 .SPX was down 0.59% at 6,081.53, and the Nasdaq Composite .IXIC was down 0.62% at 19,837.64.

The top three S&P 500 .PG.INX percentage gainers:

** Booking Holdings Inc BKNG.OQ, up 4.4%

** West Pharmaceutical Services Inc WST.N, up 3.1%

** Consolidated Edison Inc ED.N, up 2.4%

The top three S&P 500 .PL.INX percentage losers:

** Akamai Technologies Inc AKAM.OQ, down 15.1%

** Old Dominion Freight Line Inc ODFL.OQ, down 10.7%

** Unitedhealth Group Inc UNH.N, down 8.1%

The top three NYSE .PG.N percentage gainers:

** Solaris Energy Infrastructure Inc SEI.N, up 26.5%

** Cheetah Mobile Inc CMCM.N, up 11.5%

** RLX Technology Inc RLX.N, up 11.2%

The top three NYSE .PL.N percentage losers:

** Globant SA GLOB.N, down 24.1%

** Hims & Hers Health Inc HIMS.N, down 19.9%

** ACCO Brands Corp ACCO.N, down 19.6%

The top three Nasdaq .PG.O percentage gainers:

** MicroAlgo Inc MLGO.OQ, up 247.0%

** Universe Pharmaceuticals Inc UPC.OQ, up 124.6%

** OSR Holdings Inc OSRH.OQ, up 74.8%

The top three Nasdaq .PL.O percentage losers:

** PowerUp Acquisition Corp ASBP.OQ, down 45.7%

** Mobile-health Network Solutions MNDR.OQ, down 39.7%

** bluebird bio Inc BLUE.OQ, down 38.2%

** Celsius Holdings Inc CELH.O:

BUZZ - Surges on deal to buy wellness drinks brand Alani Nutrition nL3N3PC1BB

** Booking Holdings Inc BKNG.O:

BUZZ - Analysts raise PT on Booking Holdings following strong Q4 earnings nL3N3PC0PR

** Block Inc XYZ.N:

BUZZ - Falls after Q4 profit miss nL3N3PC0S6

** Home Bancorp Inc HBCP.O:

BUZZ - Gets 'overweight' rating as Piper Sandler assumes coverage nL3N3PC0V3

** Alibaba.com Ltd BABA.N:

** JD.com Inc JD.O:

** Pinduoduo Inc PDD.O:

** Bilibili Inc BILI.O:

BUZZ - China ADRs rise as tech rally lifts domestic stocks nL3N3PC0VS

** Celestica Inc CLS.N:

BUZZ - J.P. Morgan initiates Celestica with 'overweight' rating nL3N3PC0Z5

** Acelyrin Inc :

BUZZ - Jumps on Concentra Biosciences' buyout offer amid pending merger with Alumis nL3N3PC13I

** Amalgamated Financial Corp AMAL.O:

BUZZ - Falls after Piper Sandler cuts to 'neutral' nL3N3PC0W7

** Waystar Holding Corp :

BUZZ - Ticks lower as top shareholders slice stake in upsized secondary offering nL3N3PC0U8

** FirstSun Capital Bancorp FSUN.O:

BUZZ - Rated 'overweight' as Piper Sandler starts coverage nL3N3PC11C

** Atmus Filtration Technologies Inc :

BUZZ - Gains after upbeat Q4 results, annual forecasts nL3N3PC13R

** Bluebird bio Inc BLUE.O:

BUZZ - Falls on discounted take private deal with Carlyle, SK Capital nL3N3PC14P

** Coinbase Global Inc COIN.O:

BUZZ - Rises after SEC decision to drop lawsuit nL3N3PC14C

** MeiraGTx Holdings PLC MGTX.O:

BUZZ - Rises on positive data from genetic eye condition treatment nL3N3PC15I

** Glaukos Corp GKOS.N:BUZZ - Falls on wider-than-expected Q4 loss nL3N3PC15H

** MercadoLibre Inc MELI.O:

BUZZ - Surges after Q4 profit beat nL3N3PC181

** Floor & Decor Holdings Inc FND.N:BUZZ - Jumps after Q4 profit, rev beat nL6N3PC0JV

** CrowdStrike Holdings Inc CRWD.O:

BUZZ - Falls on report DoJ, SEC investigating co's deal with Carahsoft nL3N3PC19W

** Rivian Automotive Inc RIVN.O:BUZZ - Falls on weak 2025 deliveries forecast, vehicle recall nL3N3PC1B0

** Ralph Lauren Corp RL.N:

BUZZ - J.P. Morgan raises Ralph Lauren PT on positive management comments nL3N3PC1BS

** Protagonist Therapeutics Inc PTGX.O:BUZZ - Rises on quarterly profit beat nL3N3PC18A

** Hims and Hers Inc HIMS.N:

BUZZ - Falls as US shortage of Novo's weight loss drug is resolved nL3N3PC1D2

(Compiled by Rajarshi Roy and Prakhar Srivastava in Bengaluru)

((Prakhar.srivastava2@thomsonreuters.com))