Updated at 10:45 a.m. ET (1545 GMT

By Chris Prentice and Greta Rosen Fondahn

NEW YORK/GDANSK, Feb 27 (Reuters) - Major Wall Street indexes were mixed on Thursday as fresh U.S. data hurt sentiment, and European stock markets fell following a threat from U.S. President Donald Trump to impose 25% tariffs on imports from the region.

Dampening some risk-taking, data showed jobless claims stood at 242,000, higher than estimates of 221,000.

Oil prices climbed as supply concerns resurfaced. Trump revoked Chevron's license to operate in Venezuela. O/R

MSCI's gauge of stocks across the globe .MIWD00000PUS fell 0.23% and the euro EUR=EBS eased. Benchmark U.S. Treasury yields rose after the U.S. data.

The Dow Jones Industrial Average .DJI rose 359.46 points, or 0.83%, to 43,792.58, the S&P 500 .SPX rose 4.48 points, or 0.08%, to 5,960.54, while the Nasdaq Composite .IXIC fell 88.14 points, or 0.46%, to 18,987.12.

Shares of Nvidia NVDA.O, which reported earnings late Wednesday, swung to losses as investors focused on signs of increased AI spending in the industry.

Trump created some confusion over the looming duties on top trading partners Canada and Mexico on Wednesday, by signalling they would take effect on April 2, which would be another month-long extension.

However, a White House official later said the previous March 4 deadline for the levies remained in effect "as of this moment", stirring further uncertainty about U.S. trade policy.

Trump also floated a 25% "reciprocal" tariff on European cars and other goods.

European stocks were weaker across the board, with the STOXX 600 index .STOXX dragged by automaker and component maker shares .SXAP in response to the potential tariffs. The technology index .SX8P was also down.

"We're almost in a situation where there is so much news that it's leaving traders paralysed, because they don't know what to focus on, and particularly with Trump, what is a negotiating gambit and what is a serious policy proposal," said Michael Brown, senior research strategist at Pepperstone.

"Given the degree of uncertainty, it does make sense to lighten up on positioning, particularly in riskier assets."

The yield on benchmark U.S. 10-year notes US10YT=RR rose 3.8 basis points to 4.287%, and the 2-year note US2YT=RR yield, which typically moves in step with interest rate expectations for the Federal Reserve, rose 2.8 basis points to 4.1%.

US GROWTH JITTERS

The greenback, which has been under pressure in recent weeks, rose, with the dollar index =USD, which measures the greenback against a basket of currencies including the yen and the euro, up 0.64%.

Traders have raised bets for Federal Reserve interest rate cuts, now seeing two quarter-point reductions this year, with the first likely in July. IRPR

The Fed's preferred inflation gauge, the Personal Consumption Expenditure (PCE) index, is due on Friday.

"Markets are starting to feel less confidence about U.S. growth," said Shoki Omori, chief global desk strategist at Mizuho Securities.

Nvidia shares NVDA.O were up about 1% in pre-market trading, after slipping 1.5% after the bell on Wednesday despite the heavyweight U.S. chipmaker and artificial intelligence pioneer giving a strong growth forecast for the first quarter.

Cryptocurrency bitcoin BTC= gained 1.41% to $85,647.82, following a nearly 12% tumble over the first three days of this week.

Bitcoin bull Geoff Kendrick, global head of digital assets research at Standard Chartered, cautioned against buying the dip just yet in a note to clients.

"Stay patient," he said. "These types of losses rarely end well and I still think the big capitulation is yet to come."

Spot gold XAU= fell 1.41% to $2,875.13 an ounce, pressured by a stronger U.S. dollar and rising yields.

(Reporting by Kevin Buckland and Greta Rosen Fondahn; Editing by Susan Fenton, Kirsten Donovan, Philippa Fletcher)

((Kevin.Buckland@thomsonreuters.com;))