基石药业(02616.HK) 公布，其自主研发的PD-1/VEGF/CTLA-4三特异性抗体CS2009的全球多中心I期临床试验顺利完成首例患者给药，未发生输液反应或其他不良事件。
该试验将深入评估CS2009在多种晚期实体瘤中的临床应用价值，包括非小细胞肺癌、肝癌、胃癌、子宫内膜癌、卵巢癌、肾细胞癌及宫颈癌等，旨在推动创新肿瘤免疫疗法的发展。
临床前研究显示，CS2009的抗肿瘤活性优于潜在竞品。CS2009通过叠加CTLA-4抑制功能以及对PD-1和VEGFA的阻断，预期能进一步提升对PD-(L)1疗法响应不佳的PD-L1低表达或PD-L1阴性患者的疗效，使CS2009具备成为同类首创/同类最优的下一代肿瘤免疫骨架产品的潜力，从而替代现有以PD-(L)1为基础的疗法。(jl/w)(港股报价延迟最少十五分钟。)
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