智通财经APP获悉，中国国家药监局药品审评中心(CDE)官网近日公示，百济神州(06160)的1类新药注射用BGB-B455临床试验申请获得受理。公开资料显示，这是一款CLDN6 ×CD3双特异性抗体，为百济神州在乳腺/妇科领域布局的一款免疫细胞衔接器。本次为该产品首次在中国申报IND。

图片来源：CDE官网

Claudin蛋白是一种细胞蛋白，在癌症的发生和发展过程中发挥着重要作用。由于其在肿瘤中的表达优于正常组织，claudin 6 (CLDN6)是一种理想的靶向肿瘤抗原。

公开资料显示，BGB-B455是一种双特异性抗体(BsAbs)，其靶向肿瘤细胞上的CLDN6和T细胞上的CD3受体。它可能以更耐受的方式提供CLDN6依赖性抗肿瘤免疫应答，而不会产生过度的全身毒性。

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