Arvinas Shares Dive on Trial Results for Metastatic Breast Cancer Treatment

Dow Jones

Mar 11, 2025

By Denny Jacob

Arvinas shares dived 40% following results from a Phase 3 clinical trial evaluating vepdegestrant as a treatment for a type of metastatic breast cancer.

Shares were trading around $10.35. The stock is down 61% over the last year.

The biopharmaceutical company in conjunction with Pfizer said the trial did not reach statistical significance in improvement in progression-free survival in the intent-to-treat population.

The trial, however, did meet its primary endpoint in the estrogen receptor 1-mutual population, which the company said demonstrated a statistically significant and clinically meaningful improvement in progression-free survival compared to fulvestrant.

The two companies in July 2021 announced plans to collaborate on the co-development and co-commercialization of vepdegestrant.

Write to Denny Jacob at denny.jacob@wsj.com

(END) Dow Jones Newswires

March 11, 2025 08:37 ET (12:37 GMT)

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The stock is down 61% over the last year. \n\n\n  The biopharmaceutical company in conjunction with Pfizer said the trial did not reach statistical significance in improvement in progression-free survival in the intent-to-treat population. \n\n\n  The trial, however, did meet its primary endpoint in the estrogen receptor 1-mutual population, which the company said demonstrated a statistically significant and clinically meaningful improvement in progression-free survival compared to fulvestrant. \n\n\n  The two companies in July 2021 announced plans to collaborate on the co-development and co-commercialization of vepdegestrant. \n\n\n \n\n\n  Write to Denny Jacob at denny.jacob@wsj.com \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  March 11, 2025 08:37 ET (12:37 GMT)\n\n\n  Copyright (c) 2025 Dow Jones & Company, Inc.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"-2","news_tag":"dataReport","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":true,"code":"91000000","status":"200"}}}