智通财经APP获悉，3月19日，中国国家药监局药品审评中心(CDE)官网最新公示，赛诺菲(SNY.US)申报的度普利尤单抗注射液一项新适应症上市申请拟纳入优先审评，拟定适应症为大疱性类天疱疮。

3月11日，再生元(REGN.US)和赛诺菲公布了度普利尤单抗治疗中重度大疱性类天疱疮(BP)成人患者的关键性2/3期临床研究结果，该试验达到了所有主要及关键次要终点，接受度普利尤单抗治疗的患者获得持久缓解的比例是安慰剂组的5倍。目前，美国FDA已经接受度普利尤单抗用于治疗成人BP的上市申请，并授予其优先审评资格。

截图来源：CDE官网

BP是一种慢性且易复发的皮肤病，伴有潜在的2型炎症，通常发生于老年人群。其特点为剧烈瘙痒、水疱、皮肤发红及疼痛性病变。水疱和皮疹可能遍布全身，导致皮肤出血和结痂，使患者更易感染，并影响日常生活。

度普利尤单抗(dupilumab)是FDA批准的首个抗IL-4Rα抗体，由赛诺菲和再生元联合开发。它能够通过IL-4和IL-13“双靶点”的创新作用机制阻断2型炎症通路，降低2型炎症的病理性反应，从机制上治疗2型炎症相关疾病。研究表明，IL-4和IL-13是2型炎症的关键驱动因素，在多种炎症性疾病中发挥重要作用。

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