Wall Street's main stock indexes fell on Wednesday, dragged down by megacap stocks, as investors awaited clearer guidance on the Trump administration's forthcoming tariffs expected to be enacted next week. .N

At 13:30 EDT, the Dow Jones Industrial Average .DJI was down 0.39% at 42,421.52.The S&P 500 .SPX was down 1.12% at 5,711.71, and the Nasdaq Composite .IXIC was down 1.96% at 17,914.24.

The top three S&P 500 .PG.INX percentage gainers:

** Cintas Corp CTAS.OQ, up 6.5%

** Dollar Tree Inc DLTR.OQ, up 5.4%

** Paychex Inc PAYX.OQ, up 5.2%

The top three S&P 500 .PL.INX percentage losers:

** Super Micro Computer Inc SMCI.OQ, down 8.6%

** Arista Networks Inc ANET.N, down 7.2%

** Vistra Corp VST.N, down 6.7%

The top three NYSE .PG.N percentage gainers:

** Worthington Enterprises Inc WOR.N, up 21.9%

** GameStop Corp GME.N, up 14.6%

** Braskem SA BAK.N, up 14.0%

The top three NYSE .PL.N percentage losers:

** GCT Semiconductor Holding Inc GCTS.N, down 13.9%

** Vertiv Holdings Co VRT.N, down 11.8%

** Bally's Corp BALY.N, down 11.1%

The top three Nasdaq .PG.O percentage gainers:

** Petros Pharmaceuticals Inc PTPI.OQ, up 225.1%

** Ocean Biomedical Inc OCEA.OQ, up 137.7%

** OSR Holdings Inc OSRH.OQ, up 102.5%

The top three Nasdaq .PL.O percentage losers:

** Acrivon Therapeutics Inc ACRV.OQ, down 38.8%

** Benson Hill Inc BHIL.OQ, down 33.0%

** Tenon Medical Inc TNON.OQ, down 31.7%

** Dollar Tree Inc <DLTR.O>:BUZZ - Gains on sale of Family Dollar banner for $1 billion nL3N3Q9161

** Theratechnologies Inc <THTX.O>:BUZZ - Gets FDA nod for new treatment of abdominal fat in HIV patients, shares soar nL3N3Q90QL

** JinkoSolar Holding Co Ltd <JKS.N>:BUZZ - Falls after weak Q4 results due to lower price of solar modules nL3N3Q90RU

** GameStop Corp <GME.N>:BUZZ - Climbs on bitcoin bet nL3N3Q90UR

** Humacyte Inc <HUMA.O>: BUZZ - Tumbles on pricing $50 mln stock offering nL6N3Q90IA

** StandardAero Inc <SARO.N>: BUZZ - Dips as Carlyle carves stake in upsized $1 bln secondary offering nL6N3Q90IR

** Rio Tinto Ltd <RIO.N>:

** BHP Group Ltd < BHP.N>:

** Southern Copper Corp <SCCO.N>:

** Freeport-McMoran Inc <FCX.N>: BUZZ - Copper miners climb as US import tariff fears mount nL3N3Q90WX

** Chewy Inc <CHWY.N>: BUZZ - Rises after Q4 profit beat nL3N3Q90WW

** Wingstop Inc <WING.O>: BUZZ - Wells Fargo starts coverage on Wingstop with 'overweight' rating nL3N3Q90YC

** American Electric Power Company Inc <AEP.O>: BUZZ - BMO Capital Markets raises PT on American Electric Power nL3N3Q90QT

** GFL Environmental Inc <GFL.N>: BUZZ - Ticks higher after upsized $900 mln secondary offering nL6N3Q90KB

** V2X Inc <VVX.N>: BUZZ - Rises after $921 million US Army contract nL3N3Q911W

** Wave Life Sciences Ltd <WVE.O>: BUZZ - Rises after positive data on muscle disorder drug nL3N3Q90YW

** Cintas Corp <CTAS.O>: BUZZ - Up after uniform rental firm raises annual profit forecast nL3N3Q9184

** Qifu Technology Inc <QFIN.O>: BUZZ - Stabilizes after $600 mln convertible bond sale nL6N3Q90KV

** OrganiGram Holdings <OGI.O>: BUZZ - Gains after rebrand, global expansion plans nL3N3Q90VS

** Global Water Resources Inc <GWRS.O>: BUZZ - Slides on stock sale nL6N3Q90LN

** Pfizer Inc <PFE.N>:

** BridgeBio Pharma Inc <BBIO.O>:

** Alnylam Pharmaceuticals Inc <ALNY.O>: BUZZ - Heart disease drug remains 'mainstay treatment' despite new entries, Oppenheimer says nL3N3PN1XE

** Phillips 66 <PSX.N>: BUZZ - Rises after proposing new board members amid Elliott dispute nL3N3Q90UJ

** SurgePays Inc <SURG.O>: BUZZ - Soars after rosy outlook nL6N3Q90MO

** Palvella Therapeutics Inc <PVLA.O>: BUZZ - Stifel initiates Palvella with 'buy' rating on skin treatment prospects nL3N3PJ1LT

** B. Riley Financial Inc <RILY.O>: BUZZ - Shares jump on private bond exchange to cut debt nL3N3Q918Z

** Exxon Mobil Corp <XOM.N>:

** Chevron Corp <CVX.N>:

** EOG Resources Inc < EOG.N>:

** Occidental Petroleum Corp <OXY.N>: BUZZ - US energy companies gain on crude oil inventory fall, Venezuela supply worries nL3N3Q91AM

** CarMax Inc <KMX.N>: BUZZ - Rises after Stephens raises rating ahead of Q4 results nL3N3Q91AV

** Coty Inc <COTY.N>:

** Ulta Beauty Inc <ULTA.O>: BUZZ - Jefferies bearish on brick and mortar beauty retailers nL3N3Q91BV

** Exelixis Inc <EXEL.O>: BUZZ - Cancer drug gets FDA approval but analysts say its priced in; shares down nL3N3Q91CB

** Vertiv Holdings Inc <VRT.N>: BUZZ - Falls after Barclays cuts PT nL2N3Q90TO

** Vita Coco Company Inc <COCO.O>: BUZZ - Falls after Ningi Research says short on stock nL3N3Q91D1

** Perimeter Solutions Inc <PRM.N>: BUZZ - Rallies after UBS turns bullish on wildfires demand nL6N3Q90QL

** Jefferies Financial Group Inc <JEF.N>: BUZZ - Shares down; Q1 EPS, rev seen rising y/y nL2N3Q90TU

(Compiled by Kritika Lamba and Rajarshi Roy in Bengaluru)

((Rajarshi.Roy@thomsonreuters.com))