As the U.S. market experiences heightened volatility with major indices like the S&P 500 and Nasdaq Composite closing sharply lower amid tariff concerns, investors are closely monitoring economic indicators that could impact small-cap companies and technology stocks. In such a climate, identifying high-growth tech stocks involves looking for companies that demonstrate resilience through innovation and adaptability to shifting trade policies, making them noteworthy in this unpredictable environment.

Top 10 High Growth Tech Companies In The United States

Click here to see the full list of 234 stocks from our US High Growth Tech and AI Stocks screener.

Here's a peek at a few of the choices from the screener.

Akebia Therapeutics

Simply Wall St Growth Rating: ★★★★★☆

Overview: Akebia Therapeutics, Inc. is a biopharmaceutical company dedicated to developing and commercializing therapeutics for patients with kidney diseases, with a market cap of $418.13 million.

Operations: Akebia focuses on developing and commercializing novel therapeutics for kidney disease, generating $160.18 million in revenue from this segment.

Akebia Therapeutics, despite its unprofitable status, is poised for significant growth with expected annual revenue increases of 27.2% outpacing the U.S. market's 8.2%. This biotech firm is navigating towards profitability within three years, bolstered by a robust pipeline evidenced by recent positive CHMP opinions on XOANACYL® for CKD-related conditions. However, financial challenges remain as highlighted by a $69.41 million net loss in 2024 and ongoing equity offerings to raise capital, including a recent $50 million issuance. Balancing innovation with financial sustainability will be crucial for Akebia's advancement in the competitive biotech landscape.

• Take a closer look at Akebia Therapeutics' potential here in our health report.

• Review our historical performance report to gain insights into Akebia Therapeutics''s past performance.

aTyr Pharma

Simply Wall St Growth Rating: ★★★★★☆

Overview: aTyr Pharma, Inc. is a biotherapeutics company focused on discovering and developing medicines based on novel functions of tRNA synthetases in the United States, with a market cap of $253.25 million.

Operations: The company generates revenue primarily from its biotechnology segment, specifically targeting startups, with reported earnings of $0.24 million.

aTyr Pharma, despite its modest revenue of $0.235 million in 2024, is positioned for rapid expansion with a projected annual revenue growth rate of 59.2%, significantly outpacing the U.S. market average of 8.2%. The recent appointment of Dalia R. Rayes as Head of Commercial underscores a strategic push to enhance global commercial operations, particularly for their lead therapeutic candidate efzofitimod in pulmonary sarcoidosis—a move that could catalyze future profitability and market presence. Moreover, the ongoing Phase 3 EFZO-FIT™ study's continuation without modifications by an independent DSMB highlights promising interim safety results, supporting long-term value creation through scientific advancement and targeted therapy development.

• Click to explore a detailed breakdown of our findings in aTyr Pharma's health report.

• Understand aTyr Pharma's track record by examining our Past report.

MeiraGTx Holdings

Simply Wall St Growth Rating: ★★★★★☆

Overview: MeiraGTx Holdings plc is a clinical-stage genetic medicines company dedicated to developing treatments for patients with serious diseases, with a market capitalization of $453.42 million.

Operations: MeiraGTx Holdings generates revenue primarily from its biotechnology segment, focusing on startups, with reported earnings of $33.28 million.

MeiraGTx Holdings, despite its unprofitability, is making significant strides in the high-growth tech landscape with a projected annual revenue growth of 31.8% and earnings expected to increase by 43.0% annually. The company's commitment to innovation is evident from its recent strategic alliance with Hologen Limited, which includes a substantial $200 million upfront payment and up to $230 million in committed capital for developing treatments for Parkinson’s disease using advanced AI technologies. This collaboration not only underscores MeiraGTx's focus on neurodegenerative disorders but also highlights its pioneering approach in integrating AI with genetic medicine, positioning it well within the tech-driven biotech sector.

• Dive into the specifics of MeiraGTx Holdings here with our thorough health report.

• Gain insights into MeiraGTx Holdings' historical performance by reviewing our past performance report.

Seize The Opportunity

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

Companies discussed in this article include NasdaqCM:AKBA NasdaqCM:ATYR and NasdaqGS:MGTX.

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