The opinions expressed here are those of the author, the EMEA Markets Breaking News Editor at Reuters.

By Amanda Cooper

April 22 (Reuters) - Morning Bid U.S.

What matters in U.S. and global markets today

By Amanda Cooper, EMEA Markets Breaking News Editor

It's no secret that U.S. President Donald Trump is not a fan of Federal Reserve Chair Jerome Powell, despite having appointed him to lead the U.S. central bank in 2018 during his first term in office.

But in the face of a cratering stock market, the destruction of investor confidence in U.S. assets and the increasing likelihood of recession - all unleashed by the chaotic rollout of his tariff policies - Trump is demanding the Federal Reserve cut interest rates and for heads to roll, specifically, Powell's.

Mike Dolan is enjoying some well-deserved time off this week, but the Reuters markets team is here to provide you with all the information you need to start your day.

Today's Market Minute

* Trump has kept up his verbal assault on Federal Reserve Chair Jerome Powell over the Fed's refusal for now to cut rates further, making investors increasingly fearful he could try to fire the U.S. central bank chief over the matter.

* Swiss pharmaceutical maker Roche says it will invest $50 billion in the United States over the next five years, creating more than 12,000 new jobs.

* Trump sat down with major retailers including Walmart, Home Depot, Lowe's and Target on Monday to discuss his tariff policies that could raise the prices of the goods on their shelves.

* Vietnam's trade ministry has issued a directive to crack down on illegal transhipment of goods to the United States and other trading partners as it tries to avoid steep U.S. tariffs, according to a document reviewed by Reuters.

* Retail investors in China are stepping in to "buy the dip" to defend their domestic stock market as their country's trade war with the United States heats up.

'Major loser' reporting for duty

Trump has opened fire on the Fed chief on his Truth Social platform, saying Powell's "termination cannot come soon enough" and calling him a "major loser".

Powell's stance is that rates should not fall until it is clear Trump's tariff plans won't fuel a surge in inflation.

The Polymarket online betting platform for political events shows its users are placing a 21% chance on Trump removing Powell from his post this year, before the Fed chair's term expires in May 2026.

Nervousness over Trump's war of words has spread to Main Street as well.

Google Trends shows searches among U.S.-based users for "Jerome Powell" have spiked to their highest in at least five years, along with "apply for UK visa".

It's not clear if Trump has the authority to remove Powell before his term is up next year. Even if he were successful in doing so, the way the Fed is structured means the remaining board members and regional bank presidents still set monetary policy.

Trump's initial social media post last week criticising Powell barely caused a ripple across markets, which were very much in recovery mode, attempting to find some kind of stability after the two-week roller coaster of early April.

But his post on Monday, in which he warned the economy would slow unless Powell cut rates, hit a market with very little in the way of liquidity - given much of the world was off for the Easter break - stripping more than 2% off the S&P and the Nasdaq, hitting Treasury prices and the dollar.

"With these costs trending so nicely downward, just what I predicted they would do, there can almost be no inflation, but there can be a SLOWING of the economy unless Mr. Too Late, a major loser, lowers interest rates, NOW," Trump's post said.

U.S. consumer inflation eased in March, thanks to declines in the price of gasoline and used vehicles. But tariffs are likely to raise the cost of most imported goods and could fuel a resurgence in price pressures. A recent measure of where consumers believe inflation will be in a year's time shot to the highest since 1981.

Even if the legality of removing Powell is unclear and Trump's verbal attacks amount to little more than that, it raises the question of the independence of the world's most powerful central bank, striking another blow to confidence.

And if there is one thing sorely lacking right now, it's confidence -- confidence in U.S. markets.

Treasuries have been so badly battered this month that the premium investors demand to hold U.S. 10-year debt rather than German bonds has increased by 48 basis points so far in April to nearly 200 basis points, heading for its biggest monthly rise since June 2003, according to LSEG data.

Meanwhile, the S&P 500 has given up all its edge over the rest of the world. So far this year, the benchmark U.S. index has fallen 13%, while the MSCI All-World Ex-US index has risen 4.2%. There are worse performers out there. Tokyo's Nikkei has fallen 14%, but this is partly a function of Japanese monetary policy and the performance of the yen. The S&P has just recorded its worst performance over the first four months of the year against the rest of the world, as measured by the MSCI index, since 1993.

There's a clear "major loser" right now and it's on Wall Street.

Chart of the day

Roche, the Swiss drugmaker, is the latest European company to announce plans to expand its presence, or set up shop, in the United States to mitigate the impact of Trump's tariffs. The company says it will invest $50 billion in the U.S. over the next five years, which it says will create over 12,000 jobs. Once the new and expanded manufacturing facilities are online, Roche says it will export more medicines from the U.S. than it imports. Pharmaceutical exports are big business both for the European Union and the United States. Medicines and other pharmaceutical products accounted for almost a quarter of all EU exports to the U.S. in 2024.

Today's events to watch

* Tesla first-quarter earnings after the market close

* Baker Hughes first-quarter earnings after the bell

* Federal Reserve Bank of Philadelphia President Patrick Harker, Richmond Fed President Thomas Barkin and Fed Board Governor Adriana Kugler speak at separate events.

* Richmond Fed Composite index for April

* Two-year Treasury note auction

(Reporting by Amanda Cooper; Editing by Aidan Lewis)

((amanda.cooper@thomsonreuters.com; +442031978531; Bluesky: @acoops.bsky.social;))