智通财经APP获悉，1 月 24 日，艾伯维(ABBV.US)与 Neomorph 宣布达成一项合作与许可选择协议，以共同开发针对肿瘤学和免疫学多个靶点的新型分子胶降解剂。根据协议条款，Neomorph 将从艾伯维获得一笔预付款，并有资格获得高达 16.4 亿美元的总额期权费和里程碑费，以及净销售额的分级特许权使用费。
据了解，分子胶降解剂是一类新型小分子，旨在选择性靶向和触发导致癌症生长或免疫系统失调的蛋白质的降解，从而提供更精准的治疗方法。分子胶降解剂有可能靶向历史上被定义为“无药可用”的蛋白质。
Insight 数据库显示，除了与 Neomorph 达成的合作，自2025年起，艾伯维还通过多项合作深化了神经系统疾病、肿瘤领域的布局。其中包括扩大与AbCellera的合作开发用于肿瘤学的新型TCE；与先声再明就多发性骨髓瘤三抗候选创新药 SIM0500 达成合作；行使与 Capsida Biotherapeutics 持续合作下首个神经退行性疾病项目的选择权。
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