该研究通过回顾性分析1974年至2016年间在英国被诊断为儿童和青年癌症（CYAC）的幸存者，探讨了不同治疗方法对糖尿病风险的影响。研究共纳入4,238名患者，中位随访时间为14.4年，期间确诊163例（3.8%）糖尿病患者。结果显示，全身放射治疗（TBI）显著增加糖尿病风险，40年累积发生率为21.0%；接受糖皮质激素治疗的患者40年后糖尿病风险增加7.7%；接受造血干细胞移植（HSCT）的患者40年累积发生率为19.6%，其中异体HSCT患者的40年累积发生率高达25.7%，而自体移植患者为7.9%。这些发现强调了特定治疗方法与长期糖尿病风险之间的关联，有助于指导未来的临床决策和随访管理。
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