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Ltd.","value":-1.569789,"marketCap":84870616},{"symbol":"KAPA","name":"Kairos Pharma, Ltd.","value":-5.061849,"marketCap":13874527},{"symbol":"MURA","name":"Mural Oncology","value":-0.38098,"marketCap":58585607},{"symbol":"TRML","name":"Tourmaline Bio","value":-4.949722,"marketCap":316173381},{"symbol":"CTOR","name":"CITIUS ONCOLOGY INC","value":-3.224122,"marketCap":74414498},{"symbol":"INBX","name":"Inhibrx Biosciences","value":0.113748,"marketCap":196582776},{"symbol":"MTSR","name":"Metsera Inc.","value":-17.732316,"marketCap":3001815168},{"symbol":"NNNN","name":"Anbio Biotechnology","value":131.651652,"marketCap":296704512}]}},"$inf$@#url:\"https://stock-news.skytigris.cn/v2/news/list\",params:#symbols:\"ALLO\",pageSize:16,pageCount:2,lang_content:\"en\",edition:\"fundamental\",,,undefined,":[{"items":[{"id":"2507330686","title":"Press Release: Allogene Therapeutics Announces Benjamin M. Beneski as Senior Vice President and Chief Technical Officer","url":"https://stock-news.laohu8.com/highlight/detail?id=2507330686","media":"Dow Jones","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2507330686?lang=en_us&edition=fundamental","pubTime":"2025-01-29 21:30","pubTimestamp":1738157400,"startTime":"0","endTime":"0","summary":"SOUTH SAN FRANCISCO, Calif., Jan. 29, 2025  -- Allogene Therapeutics, Inc. , a clinical-stage biotechnology company pioneering the development of allogeneic CAR T  products for cancer and autoimmune disease, today announced that Benjamin M. Beneski has been promoted to Senior Vice President and Chief Technical Officer . Mr. Beneski succeeds Tim Moore, who will be stepping down at the end of February after two years with the Company. Mr. Moore's impactful career spans nearly a decade of collaboration with the broader team, during which he made significant contributions to Allogene and the field of cell and gene therapy.As CTO, Mr. Beneski will oversee Allogene's technical operations, leveraging his extensive expertise in biologics manufacturing, process development, and operational leadership to carry on the work of Mr. Moore and further advance the company's groundbreaking allogeneic cell therapy programs.Mr. Beneski's career spans over two decades in biologics manufacturing and 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analyst John Newman maintained a Buy rating on Allogene Therapeutics (ALLO – Research Report) today and set a price target of $14...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/canaccord-genuity-reaffirms-their-buy-rating-on-allogene-therapeutics-allo?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/canaccord-genuity-reaffirms-their-buy-rating-on-allogene-therapeutics-allo?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["ALLO"],"gpt_icon":0},{"id":"2506510250","title":"Allogene Therapeutics Cleared to Start Phase 1 Testing of ALLO-329 Drug Candidate","url":"https://stock-news.laohu8.com/highlight/detail?id=2506510250","media":"MT Newswires Live","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2506510250?lang=en_us&edition=fundamental","pubTime":"2025-01-28 23:54","pubTimestamp":1738079669,"startTime":"0","endTime":"0","summary":"Allogene Therapeutics  has been cleared by US regulators to begin phase 1 testing of its ALLO-329 drug candidate in patients with systemic lupus erythematosus.The upcoming study approved by the US Food and Drug Administration and slated to begin by mid-2025 takes in several types of rheumatological disorders and will evaluate the safety and efficacy of ALLO-329 in patients with lupus nephritis, idiopathic inflammatory myopathies and systemic sclerosis.The trial design also is intended to increase CAR-T cell expansion in patients and prevent rejection by having two distinct lymphodepletion arms, with patients in one part of the study receiving a dose of cyclophosphamide alone which is used by rheumatologists and the other that eliminates lymphodepletion entirely, the company said.Allogene shares were 0.3% lower in recent trading.Price: 1.95, Change: +0.02, Percent Change: +0.78","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4139","BK4505","ALLO"],"gpt_icon":0},{"id":"2506851529","title":"Allogene announces FDA cleared IND application for study of ALLO-329","url":"https://stock-news.laohu8.com/highlight/detail?id=2506851529","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2506851529?lang=en_us&edition=fundamental","pubTime":"2025-01-28 21:35","pubTimestamp":1738071332,"startTime":"0","endTime":"0","summary":"Allogene Therapeutics (ALLO) announced that the U.S. Food and Drug Administration, FDA, has cleared its Investigational New Drug, IND, application 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T Into Autoimmune Diseases","url":"https://stock-news.laohu8.com/highlight/detail?id=2506155955","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2506155955?lang=en_us&edition=fundamental","pubTime":"2025-01-28 21:30","pubTimestamp":1738071002,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250128:nTUA8HWGVZ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4505","BK4139","ALLO"],"gpt_icon":0},{"id":"2506851576","title":"Allogene Therapeutics Secures U.S. FDA IND Clearance for ALLO-329, Advancing its Next-Generation Allogeneic CAR T into Autoimmune Diseases","url":"https://stock-news.laohu8.com/highlight/detail?id=2506851576","media":"GlobeNewswire","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2506851576?lang=en_us&edition=fundamental","pubTime":"2025-01-28 21:30","pubTimestamp":1738071000,"startTime":"0","endTime":"0","summary":"Dual-Targeted CD19/CD70 Allogeneic CAR T: Best-in-Class Design to Enhance Therapeutic Benefit and Expand Treatment Potential Across a Range of Autoimmune Disease Indications. Innovative Dagger Technology: Empowers ALLO-329 to Overcome Rejection, Potentially Reducing or Eliminating Reliance on Traditional Lymphodepletion. Phase 1 RESOLUTION Rheumatology Basket Trial: Initiation Planned for Mid-2025, Targeting Proof-of-Concept to Demonstrate Allogeneic Potential and the Dagger Effect on Lymphodepletion by Year-End 2025. ALLO-329 represents a next-generation approach to autoimmune therapy, featuring a dual-targeting design against CD19+ B-cells and CD70+ activated T-cells. This innovative strategy is designed to deliver superior therapeutic benefit by addressing both B-cell and T-cell dysfunction, which drive immune dysregulation in autoimmune diseases. The incorporation of Allogene’s proprieta","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/allogene-therapeutics-secures-u-fda-133000401.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4139","BK4022","BK4505","ALLO","BK4230","CAR"],"gpt_icon":0},{"id":"2494538336","title":"Press Release: Vor Bio Announces $55.6 Million Private Placement","url":"https://stock-news.laohu8.com/highlight/detail?id=2494538336","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2494538336?lang=en_us&edition=fundamental","pubTime":"2024-12-27 22:00","pubTimestamp":1735308000,"startTime":"0","endTime":"0","summary":"Intend to announce updated clinical data from Phase 1/2 VBP301 trial of VCAR33 in the first half of 2025 and updated clinical data from Phase 1/2a VBP101 trial of trem-cel in combination with Mylotarg in the second half of 2025. Extends cash runway through release of updated data from VBP101 and VBP301 trials in 2025. Vor Bio expects to use net proceeds from the PIPE to fund clinical and preclinical development of its pipeline candidates and for general corporate purposes. The PIPE is expected to close on December 30, 2024, subject to the satisfaction of customary closing conditions.","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["ALLO","VOR","BK4139","BK4505"],"gpt_icon":0},{"id":"2494489498","title":"3 Beaten-Down Biotech Stocks to Buy for a Turnaround in 2025","url":"https://stock-news.laohu8.com/highlight/detail?id=2494489498","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2494489498?lang=en_us&edition=fundamental","pubTime":"2024-12-27 02:07","pubTimestamp":1735236420,"startTime":"0","endTime":"0","summary":"The biotech sector witnessed a see-saw performance in 2024. Though the year started on a positive note, those gains were erased in the second half due to disappointing third-quarter results, guidance cuts, pipeline setbacks and the appointment of vaccine skeptic Robert F. Kennedy Jr. as the head of Health and Human Services.Despite these setbacks, the sector continued to attract investors’ attention due to demand for innovative medicines, especially in areas with great commercial potential, like obesity, immunology and gene therapy. New drug approvals, pipeline progress and an increase in M&A activity were some of the positives in the sector in 2024.Here, we discuss three drug/biotech stocks that took a beating in 2024 but are likely to bounce back in 2025 based on anticipated regulatory approvals and/or positive pipeline updates. These are Immunocore Holdings IMCR, Allogene Therapeutics ALLO and Day One Biopharmaceuticals DAWN.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/3-beaten-down-biotech-stocks-180700940.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4231","BK4139","BK4505","BK4080","DAWN","ALLO","BK4539","IMCR","ADC"],"gpt_icon":0},{"id":"2494889959","title":"Allogene Therapeutics (ALLO) Upgraded to Buy: What Does It Mean for the Stock?","url":"https://stock-news.laohu8.com/highlight/detail?id=2494889959","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2494889959?lang=en_us&edition=fundamental","pubTime":"2024-12-27 01:00","pubTimestamp":1735232410,"startTime":"0","endTime":"0","summary":"Investors might want to bet on Allogene Therapeutics , as it has been recently upgraded to a Zacks Rank #2 . This upgrade is essentially a reflection of an upward trend in earnings estimates -- one of the most powerful forces impacting stock prices.The Zacks rating relies solely on a company's changing earnings picture. It tracks EPS estimates for the current and following years from the sell-side analysts covering the stock through a consensus measure -- the Zacks Consensus Estimate.Since a changing earnings picture is a powerful factor influencing near-term stock price movements, the Zacks rating system is very useful for individual investors. They may find it difficult to make decisions based on rating upgrades by Wall Street analysts, as these are mostly driven by subjective factors that are hard to see and measure in real time.Therefore, the Zacks rating upgrade for Allogene Therapeutics basically reflects positivity about its earnings outlook that could translate into buying pres","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/allogene-therapeutics-allo-upgraded-buy-170010826.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["ALLO"],"gpt_icon":0},{"id":"2493082439","title":"3 Under-$10 Drug Stocks Wall Street Analysts Recommend Buying","url":"https://stock-news.laohu8.com/highlight/detail?id=2493082439","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2493082439?lang=en_us&edition=fundamental","pubTime":"2024-12-24 20:47","pubTimestamp":1735044420,"startTime":"0","endTime":"0","summary":"The year 2024 has been a mixed ride for the biotech industry. It started on a positive note, attracting investors’ attention in areas with great commercial potential, like obesity, immunology and gene therapy.However, their interest started to wane in the second half of the year amid lower-than-expected third-quarter results, guidance cuts and pipeline setbacks. While Wall Street viewed Trump’s victory as an accelerant for M&A activity in the sector, the President-elect’s decision to nominate vaccine skeptic Robert F. Kennedy Jr. to run the Department of Health and Human Services concerned investors in biotech stocks. These factors have negatively impacted nearly all companies in the industry. Year to date, the biotech sector has declined nearly 14%.Investing in low-priced stocks with the potential for a healthy return is a good idea. One of the safest options to capitalize on money-making opportunities is following Wall Street recommendations and their experts’ advice.","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/X_G78K7TS0Wks9k_NbYhwg--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/181d5ab1675d8aae9c53428215552644","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/X_G78K7TS0Wks9k_NbYhwg--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/181d5ab1675d8aae9c53428215552644"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/3-under-10-drug-stocks-124700943.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU2125154935.USD","VNDA","LU2360032135.SGD","ABR","BK4161","LU0128526141.USD","LU0029874061.USD","LU2125154778.USD","BK4505","ALLO","RZLT","BK4139","HI","BK4110"],"gpt_icon":0},{"id":"2489143419","title":"PCRX Receives New Patent for Lead Pain Drug Exparel in the US","url":"https://stock-news.laohu8.com/highlight/detail?id=2489143419","media":"Zacks","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489143419?lang=en_us&edition=fundamental","pubTime":"2024-12-05 01:10","pubTimestamp":1733332200,"startTime":"0","endTime":"0","summary":"Pacira BioSciencesPCRX announced the reception of the ‘940 patent from the U.S. Patent and Trademark Officethat protects the chemical composition ofExparel , ensuring protection against generics in the market through 2044. The ‘940 patent is the first from a new family of patents related to Exparel produced by Pacira’s enhanced large-scale manufacturing process in San Diego, which received FDA approval in February 2024.Exparel is Pacira’s flagship pain-management product,which was launched in 2012. The drug is indicated for postsurgical local analgesia in patients aged six years and older. It is also indicated for regional analgesia in adults via an interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa and femoral nerve block in the adductor canal.Pacira plans to list the ‘940 patent in the FDA's Orange Book, which includes patents covering the active ingredient, drug formulation, or approved usage methods. The company is also pursuing additional patent a","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/stId3gHSUQwaleeZdH.dgQ--~B/aD00MTM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/6707b6de8d8e03441895b107371eec74","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/stId3gHSUQwaleeZdH.dgQ--~B/aD00MTM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/6707b6de8d8e03441895b107371eec74"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/pcrx-receives-patent-lead-pain-171000813.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4505","LU0122379950.USD","LU1066053197.SGD","LU1894683348.USD","SGXZ57979304.SGD","IE0002270589.USD","IE00B19Z3581.USD","LU0234572021.USD","SG9999002232.USD","BK4550","IE00BLSP4452.SGD","LU0234570918.USD","LU0889565916.HKD","LU1571399168.USD","BK4578","IE00B7SZLL34.SGD","IE00BLSP4239.USD","LU0306807586.USD","BK4566","IE00BSNM7G36.USD","LU0321505439.SGD","PFE","IE000M9KFDE8.USD","IE00BBT3K403.USD","LU0225284248.USD","PCRX","LU0320765992.SGD","LU0306806265.USD","ALLO","LU1894683264.USD","SG9999003800.SGD","LU1023059063.AUD","LU0109394709.USD","BK4599","LU1839511570.USD","BK4534","LU1883839398.USD","LU0289739699.SGD","BK4533","LU1430594728.SGD","BK4585","GILD","SG9999001176.SGD","LU2087621335.USD","LU0868494617.USD","LU1585245621.USD","SG9999011175.SGD","BK4592","BK4532","LU2468319806.SGD"],"gpt_icon":1},{"id":"2489434143","title":"ITCI Submits sNDA to the FDA for Expanded Use of Caplyta in MDD","url":"https://stock-news.laohu8.com/highlight/detail?id=2489434143","media":"Zacks","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489434143?lang=en_us&edition=fundamental","pubTime":"2024-12-05 01:00","pubTimestamp":1733331600,"startTime":"0","endTime":"0","summary":"Intra-Cellular TherapiesITCI announced that it has submitted a supplemental new drug application  to theFDA aiming to expand the approved uses of its lead drug, Caplyta , to include treating major depressive disorder  in adults as an adjunctive therapy to antidepressants.The sNDA submission is supported by positive results from two late-stage studies, Studies 501 and 502, that evaluated 42 mg of lumateperone as an adjunctive therapy to antidepressants for MDD. Both studies met the primary and key secondary efficacy endpoints, demonstrating Caplyta’s robust antidepressant efficacy and favorable safety and tolerability profile.Subject to its approval for the MDD indication, Caplyta would be indicated for the treatment of three different major psychiatry indications affecting more than 30 million adult patients in the United States. In the past three months, shares of Intra-Cellular have gained 17.8% against the industry’s 5.1% decline.","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/ecFYZtqvCgQ1G__HXA8vTQ--~B/aD0zNDM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/00e8f1a41a7bc7b2ecf8d421f3c6f574","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/ecFYZtqvCgQ1G__HXA8vTQ--~B/aD0zNDM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/00e8f1a41a7bc7b2ecf8d421f3c6f574"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/itci-submits-snda-fda-expanded-170000000.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0985481810.HKD","IE00BBT3K403.USD","SGXZ57979304.SGD","IE00BKVL7J92.USD","IE00BSNM7G36.USD","GILD","SG9999002224.SGD","BK4550","ABVC","LU0058720904.USD","BK4588","IE0002270589.USD","LU0456855351.SGD","BK4007","LU1883839398.USD","CNS","BK4135","LU0320765992.SGD","BK4592","LU2087621335.USD","BK4578","LU1057294990.SGD","PFE","LU0170899867.USD","BK4505","LU0868494617.USD","LU0106261612.USD","LU0012050646.USD","IE00B19Z3581.USD","LU1571399168.USD","LU1023059063.AUD","LU0234572021.USD","LU0889565916.HKD","IE00B3T34201.USD","LU0321505439.SGD","IE00B7SZLL34.SGD","IE00BLSP4452.SGD","LU0053671581.USD","SG9999013999.USD","ITCI","IE00BZ1G4Q59.USD","LU0306807586.USD","LU0321505868.SGD","LU0234570918.USD","BK4568","IE000M9KFDE8.USD","ALLO","BK4566","SG9999001176.SGD","LU1585245621.USD"],"gpt_icon":1},{"id":"2488957588","title":"Allogene Therapeutics Loses 23% Year to Date: How to Play the Stock?","url":"https://stock-news.laohu8.com/highlight/detail?id=2488957588","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2488957588?lang=en_us&edition=fundamental","pubTime":"2024-12-03 02:19","pubTimestamp":1733163540,"startTime":"0","endTime":"0","summary":"Shares of Allogene Therapeutics ALLO have lost nearly 23% year to date, underperforming the industry’s 7.0% decline. The stock has also underperformed the sector and the S&P 500 during the same period, as shown in the chart below. ALLO’s shares are trading below the 50 and 200-day moving averages.ALLO Stock Underperforms Industry, Sector & S&P 500. The decline in stock price can be attributed to the strategic changes in Allogene’s pipeline, announced at the start of this year. This delayed management’s plans to bring cema-cel, its lead pipeline drug, to the market by at least a couple of years.Let’s dig into the stock’s prospects.ALLO Explores Lead Drug’s Potential as First-Line LBCL Therapy. Allogene is also planning to explore the potential of allogeneic CAR-T cell therapies in autoimmune diseases. In this regard, it plans to start an early-stage study with a new candidate, ALLO-329, in lupus/systemic lupus erythematosus  indication by first-quarter 2025 and expects to have proof-of-","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/B7EfA6ERTo_QO90H15uyXw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/9c1d11cd27737fac4805145de6e5eee0","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/B7EfA6ERTo_QO90H15uyXw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/9c1d11cd27737fac4805145de6e5eee0"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/allogene-therapeutics-loses-23-date-181900263.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4505","CSTL","SLE","BK4077","LENZ","BK4139","SPRO","ALLO","RCC","BK4196"],"gpt_icon":0},{"id":"2487734943","title":"OTLK Stock Falls on Failure to Meet Non-Inferiority Goal in AMD Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2487734943","media":"Zacks","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2487734943?lang=en_us&edition=fundamental","pubTime":"2024-11-28 23:29","pubTimestamp":1732807740,"startTime":"0","endTime":"0","summary":"Outlook TherapeuticsOTLK reported preliminary top-line results from the 90-day non-inferiority NORSE EIGHT clinical study evaluating ONS-5010  to treat patients with wet age-related macular degeneration . The NORSE EIGHT study is the second of two adequate and well-controlled clinical studies evaluating ONS-5010 for the AMD indication.Per the data readout, the candidate failed to meet the pre-specified non-inferiority endpoint at week 8 outlined in the special protocol assessment with the FDA. ONS-5010 is an investigational ophthalmic formulation of bevacizumab, which is being developed to treat AMD and other retinal diseases. Shares of Outlook Therapeutics plunged 65.2% on Wednesday in response to the news.However, preliminary analysis of study data showed vision improvement, biological activity and a favorable safety profile for ONS-5010. Treatment with the candidate was also well-tolerated in the NORSE EIGHT study with overall ocular adverse event rates comparable to Lucentis.The sa","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/wYQLwM.yHAc_hHptSu_lhQ--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/701e76528de32ecfd8ed3df2f647e9a8","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/wYQLwM.yHAc_hHptSu_lhQ--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/701e76528de32ecfd8ed3df2f647e9a8"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/otlk-stock-falls-failure-meet-152900524.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4599","LU1894683348.USD","LU1988902786.USD","GFS","OTLK","BK4532","IE00BLSP4452.SGD","BK4141","LU0979878070.USD","LU1839511570.USD","ALLO","LU0321505868.SGD","SG9999011175.SGD","LU0823434740.USD","IE00B19Z3581.USD","BK4573","LU1803068979.SGD","IE00BBT3K403.USD","BK4529","LU0889565916.HKD","IE00BMPRXN33.USD","LU1057294990.SGD","LU0390134368.USD","LU0170899867.USD","PFE","LU0109394709.USD","BK4554","LU0109392836.USD","BK4585","LU1852331112.SGD","LU0058720904.USD","LU0198837287.USD","BK4568","LU1585245621.USD","BK4583","IE0004445239.USD","LU0056508442.USD","LU1303367103.USD","LU0082616367.USD","CRL","LU1571399168.USD","LU2250418816.HKD","BK4578","GILD","BK4505","IE00BZ1G4Q59.USD","BK4530","LU0985481810.HKD","LU2458330169.SGD"],"gpt_icon":1},{"id":"2487345384","title":"APLT Stock Plunges 77% After FDA Issues CRL for Galactosemia Drug NDA","url":"https://stock-news.laohu8.com/highlight/detail?id=2487345384","media":"Zacks","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2487345384?lang=en_us&edition=fundamental","pubTime":"2024-11-28 23:13","pubTimestamp":1732806780,"startTime":"0","endTime":"0","summary":"Applied TherapeuticsAPLT announced that the FDA has issued a Complete Response Letter  for the new drug application  seeking approval for APLT’s lead candidate, govorestat, to treat classic galactosemia. The CRL stated that the FDA has reviewed the application and cannot approve the NDA in its current form due to deficiencies in the clinical study results submitted in support of the application.Applied Therapeutics isevaluating the FDA's feedback. It intends to promptly request a meeting to discuss the requirements for a potential NDA resubmission or appeal of the decision, and appropriate next steps. Shares of the company tanked 77.3% in the after-market hours, following the disappointing news.APLT’s govorestat  is a novel central nervous system penetrant ARI, which is currently being developed for three rare neurological diseases. The NDA for govorestat for the galactosemia indication was accepted by the FDA in late February under its Priority Review pathway.Year to date, shares of A","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/T8SwUImUDIjgxL38j1nI4w--~B/aD00MTQ7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/17664ed95646b97db9beb170298a16b3","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/T8SwUImUDIjgxL38j1nI4w--~B/aD00MTQ7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/17664ed95646b97db9beb170298a16b3"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/aplt-stock-plunges-77-fda-151300400.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4592","LU0985481810.HKD","LU0225771236.USD","LU1894683264.USD","LU0170899867.USD","BK4550","BK4578","SG9999002224.SGD","LU0456855351.SGD","SG9999001176.SGD","LU0234572021.USD","IE00BZ1G4Q59.USD","SGXZ57979304.SGD","BK4139","APLT","LU2087621335.USD","BK4599","GILD","BK4583","BK4566","BK4505","SG9999013999.USD","BK4581","BK4588","IE00B19Z3581.USD","LU0234570918.USD","LU1057294990.SGD","SG9999011175.SGD","LU0289739699.SGD","PFE","BK4121","LU1023059063.AUD","CRL","BK4534","LU0058720904.USD","SG9999001176.USD","IE00BSNM7G36.USD","LU0321505439.SGD","IE00BBT3K403.USD","ALLO","LU1066051498.USD","LU1571399168.USD","LU0320765992.SGD","LU1430594728.SGD","BK4007","BK4532","LU1883839398.USD","LU0868494617.USD","IE00B19Z3B42.SGD","LU0321505868.SGD"],"gpt_icon":1}],"pageSize":16,"totalPage":6,"pageCount":2,"totalSize":83}]}}