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Inc.","value":-2.808968,"marketCap":922746000},{"symbol":"ATLN","name":"Atlantic International Corp.","value":-3.866747,"marketCap":279236717}]}},"$inf$@#url:\"https://stock-news.skytigris.cn/v2/news/list\",params:#symbols:\"CRL\",pageSize:16,pageCount:12,lang_content:\"en\",edition:\"fundamental\",,,undefined,":[{"items":[{"id":"2491586364","title":"Charles River Laboratories International Inc - Amends and Restates Credit Agreement","url":"https://stock-news.laohu8.com/highlight/detail?id=2491586364","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2491586364?lang=en_us&edition=fundamental","pubTime":"2024-12-14 05:44","pubTimestamp":1734126247,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20241213:nFWN3NE0TB:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["CRL","BK4588","BK4121","BK4530","LU0390134368.USD","BK4585"],"gpt_icon":0},{"id":"2491537198","title":"Regeneron Down 15.5% Year to Date: How to Play the Stock?","url":"https://stock-news.laohu8.com/highlight/detail?id=2491537198","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2491537198?lang=en_us&edition=fundamental","pubTime":"2024-12-13 22:09","pubTimestamp":1734098940,"startTime":"0","endTime":"0","summary":"Shares of Regeneron Pharmaceuticals, Inc. REGN have dropped 15.5% in the year so far compared with the industry’s decline of 6.3%.The stock has underperformed the sector and the S&P 500 Index during this timeframe. While the stock’s performance was encouraging at the onset of 2024, challenges for lead drug Eylea have dampened investors’ sentiment of late.Eylea is an anti-vascular endothelial growth factor inhibitor approved for various ophthalmology indications.Regeneron has a collaboration agreement with Bayer BAYRY for Eylea. Regeneron records the net product sales of Eylea and Eylea HD in the United States, and Bayer records its net product sales outside the country. Regeneron records its share of profits in connection with Eylea’s sales outside the United States.REGN’s oncology franchise got a boost with the European Commission's approval of odronextamab for treating adult patients with relapsed or refractory (R/R) follicular lymphoma  or R/R diffuse large B-cell lymphoma after two","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/0.VF5p.GUKhgU24gMni2XA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/59a827b8514d5d6d47690daa5eb16f24","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/0.VF5p.GUKhgU24gMni2XA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/59a827b8514d5d6d47690daa5eb16f24"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/regeneron-down-15-5-date-140900718.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["CRL","LU0053666078.USD","LU1974910355.USD","IE00BFXG1179.USD","BK4139","REGN","RHHBY","LU2468319806.SGD","FL","LU0109394709.USD","LU0390134368.USD","LU1917777945.USD","LU2106854487.HKD","LU0058720904.USD","LU0823416689.USD","LU2362540622.SGD","LU2362541273.HKD","LU0882574055.USD","BK4121","LU2023250504.SGD","LU0114720955.EUR","BAYRY","BK4585","LU2362541513.USD","SNY","LU2089984988.USD","LU0320765992.SGD","BK4007","LU0289739699.SGD","BK4094","BK4588","LU0889565916.HKD","03165","BK4530"],"gpt_icon":0},{"id":"2490918588","title":"Is There Now An Opportunity In Charles River Laboratories International, Inc. (NYSE:CRL)?","url":"https://stock-news.laohu8.com/highlight/detail?id=2490918588","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2490918588?lang=en_us&edition=fundamental","pubTime":"2024-12-11 22:22","pubTimestamp":1733926946,"startTime":"0","endTime":"0","summary":"Charles River Laboratories International, Inc. ( NYSE:CRL ) saw a decent share price growth of 10% on the NYSE over the...","market":"sg","thumbnail":"https://images.simplywall.st/asset/industry/9551728-choice2-main-header/1585186774276","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/9551728-choice2-main-header/1585186774276"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nyse-crl/charles-river-laboratories-international/news/is-there-now-an-opportunity-in-charles-river-laboratories-in","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["LU0390134368.USD","CRL","BK4585","NYSE","BK4588","BK4121","BK4530"],"gpt_icon":0},{"id":"2489606432","title":"Market Today: Lululemon Surges, AMD Faces Demand Challenges, Apple Plans Modem Shift","url":"https://stock-news.laohu8.com/highlight/detail?id=2489606432","media":"GuruFocus","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489606432?lang=en_us&edition=fundamental","pubTime":"2024-12-07 06:32","pubTimestamp":1733524363,"startTime":"0","endTime":"0","summary":"Today's trading session was characterized by a lack of strong directional movement in major indices, as both buyers and sellers showed little conviction. However, interest in mega-cap stocks and relie","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.gurufocus.com/news/2626458/market-today-lululemon-surges-amd-faces-demand-challenges-apple-plans-modem-shift","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"gurufocus_highlight","symbols":["LU1861219969.SGD","LU2505996681.GBP","LU2092627202.USD","IE00B19Z9505.USD","AGI","LU1235295455.SGD","LU0477156953.USD","LU0957808578.USD","IE00BJJMRX11.SGD","AAPL","LU0456855351.SGD","LU0390134368.USD","CRL","LU0323591593.USD","GFS","LU1201861165.SGD","LU0154236417.USD","LULU","IE00BKDWB100.SGD","LU0265550359.USD","LU0985320562.USD","LU0077335932.USD","LU2326559502.SGD","AMZN","LU0094547139.USD","IE00B19Z8W00.USD","LU0444973449.USD","LU1235294995.USD","LU1236620750.USD","MGK","QCOM","LU2065170008.USD","LU2095319765.USD","LU2360106780.USD","LU0302445910.USD","DE","LU1974910355.USD","LU2764262908.HKD","LU2602419157.SGD","ENPH","DIS","IE00BHPRN162.USD","IE00BKPKM429.USD","LU2756315664.SGD","LU0354030438.USD","LU0079474960.USD","AMD","IE00BSNM7G36.USD","IE00BQXX3C00.GBP"],"gpt_icon":1},{"id":"2489252899","title":"Why Is Charles River (CRL) Down 8.9% Since Last Earnings Report?","url":"https://stock-news.laohu8.com/highlight/detail?id=2489252899","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489252899?lang=en_us&edition=fundamental","pubTime":"2024-12-07 00:31","pubTimestamp":1733502675,"startTime":"0","endTime":"0","summary":"A month has gone by since the last earnings report for Charles River Laboratories . Shares have lost about 8.9% in that time frame, underperforming the S&P 500.Will the recent negative trend continue leading up to its next earnings release, or is Charles River due for a breakout?Before we dive into how investors and analysts have reacted as of late, let's take a quick look at the most recent earnings report in order to get a better handle on the important catalysts.Charles River's Q3 Earnings and Revenues Beat Estimates. Charles River Laboratories International, Inc. reported third-quarter 2024 adjusted earnings per share of $2.59, which declined 4.8% year over year. The figure, however, surpassed the Zacks Consensus Estimate by 6.6%.On a GAAP basis, earnings declined 21.3% year over year to $1.33 per share.","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/26ddEdIk.0DefsBmi91u3Q--~B/aD01OTg7dz05MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/21b1f011539d3e31c28282071d344177","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/26ddEdIk.0DefsBmi91u3Q--~B/aD01OTg7dz05MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/21b1f011539d3e31c28282071d344177"],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/why-charles-river-crl-down-163115826.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["CRL","TDOC"],"gpt_icon":0},{"id":"2489234716","title":"CRL Stock to Gain From the Global Biotech Incubator Program Launch","url":"https://stock-news.laohu8.com/highlight/detail?id=2489234716","media":"Zacks","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489234716?lang=en_us&edition=fundamental","pubTime":"2024-12-06 21:01","pubTimestamp":1733490060,"startTime":"0","endTime":"0","summary":"Charles River Laboratories International, Inc.CRL has launched the Charles River Incubator Program  via its Global Innovation Center of Excellence . The initiative is designed to support early-stage biotechnology companies in the discovery, development and phase-appropriate manufacturing of advanced therapies.The latest development is expected to bolster the company’s Manufacturing Solutions segment. With this program, Charles River demonstrates a continued commitment to the global biotechnology industry by providing knowledge, connectivity and priority access to its portfolio.Per a research report, the global biotechnology market was valued at $1.55 trillion in 2023 and is projected to grow at a compound annual rate of 13.96% through 2030. The market is driven by strong government support through ini","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/Z2Y2lgbJQfUa74IVYcsxPA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/41b7bdd28f63138df08f17b665d3589a","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/Z2Y2lgbJQfUa74IVYcsxPA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/41b7bdd28f63138df08f17b665d3589a"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/crl-stock-gain-global-biotech-130100811.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU1169589451.USD","CRL","LU1169590202.USD","PEN","LU0205193047.USD","BK4007","BK4082","HAE","BK4530","PAHC","IE00B64QTZ34.USD","LU0106261612.USD","BK4121","BK4198","IE00BLDYK493.USD","BK4548","BK4585","LU0012050646.USD","LU0390134368.USD","BK4588","LU0205194284.USD"],"gpt_icon":0},{"id":"2489592459","title":"Charles River Introduces Global Biotech Incubator Program","url":"https://stock-news.laohu8.com/highlight/detail?id=2489592459","media":"Business Wire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489592459?lang=en_us&edition=fundamental","pubTime":"2024-12-05 21:00","pubTimestamp":1733403600,"startTime":"0","endTime":"0","summary":"Program offers biotechnology developers access to extensive scientific expertise and a wide ecosystem of discovery, development and manufacturing capabilities. WILMINGTON, Mass., December 05, 2024----Charles River Laboratories International, Inc.  today announced the launch of the Charles River Incubator Program , specializing in supporting early-stage biotechnology companies in the discovery, development and phase-appropriate manufacturing of advanced therapies.Building on the success of the Company’s established global Cell and Gene Therapy  Accelerator Program , the CIP focuses on nurturing innovative start-up and early-stage biotechnology companies. The objective of the CIP is to form a strong foundation for commercial viability as its participants gain momentum with the goal of imparting cost-effective, consultative regulatory and quality expertise, personnel training initiatives, and enabling access to laboratory space and equipment. Developers are invited to apply to be part of ","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/soeFVJ8qIYJku70ZjXue0g--~B/aD0zMjY7dz0xMjQ1O2FwcGlkPXl0YWNoeW9u/https://media.zenfs.com/en/business-wire.com/a432d474cf8ee8b265d89d9e8938930f","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/soeFVJ8qIYJku70ZjXue0g--~B/aD0zMjY7dz0xMjQ1O2FwcGlkPXl0YWNoeW9u/https://media.zenfs.com/en/business-wire.com/a432d474cf8ee8b265d89d9e8938930f"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/charles-river-introduces-global-biotech-130000386.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["CTA","BK4121","BK4588","CRL","BK4530","BK4139","LU0390134368.USD","BK4585","CDMO"],"gpt_icon":0},{"id":"2488507978","title":"PTCT Stock Soars on Licensing Deal With NVS for Huntington's Therapy","url":"https://stock-news.laohu8.com/highlight/detail?id=2488507978","media":"Zacks","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2488507978?lang=en_us&edition=fundamental","pubTime":"2024-12-04 02:36","pubTimestamp":1733250960,"startTime":"0","endTime":"0","summary":"Shares of PTC Therapeutics PTCT rose nearly 19% on Monday after announcing that it has entered into an exclusive global licensing and collaboration agreement with pharma giant Novartis NVS for PTC518, its investigational oral therapy for Huntington's disease .Per the terms of the deal, Novartis will be responsible for developing and marketing PTC518 in HD indication after completion of the ongoing phase II PIVOT-HD study, expected in the first half of next year. PTC Therapeutics will receive an upfront cash payment of $1 billion. The company will also be eligible to receive up to $1.9 billion in milestone payments from Novartis.While both companies will share profits and losses in the United States in the ratio of 40:60 , NVS will be responsible for ex-U.S. sales. PTCT will also be eligible to receive tiered double-digit royalties on ex-U.S. sales of the drug.The deal is expected to be closed in first-quarter 2025, subject to the fulfillment of customary closing conditions, including r","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/B7EfA6ERTo_QO90H15uyXw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/9c1d11cd27737fac4805145de6e5eee0","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/B7EfA6ERTo_QO90H15uyXw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/9c1d11cd27737fac4805145de6e5eee0"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/ptct-stock-soars-licensing-deal-183600668.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4083","LU1093756325.SGD","IE00BJT1NW94.SGD","LU0823434740.USD","LU0942090050.USD","LU0320765646.SGD","LU0823434583.USD","LU1989772923.USD","PTCT","LU0354030438.USD","BK4534","BK4533","LU0689472784.USD","IE00BFTCPJ56.SGD","LU1093756168.USD","BK4121","IE00BJJMRZ35.SGD","SPRO","BK4139","LU0943347566.SGD","BK4566","HD","LU0234572021.USD","CRL","LU0211331839.USD","IE0009355771.USD","LU0868494708.USD","LU1496350171.SGD","IE00BSNM7G36.USD","CSTL","IE00BWXC8680.SGD","LU1069344957.HKD","SG9999001440.SGD","LU0820562030.AUD","IE00B1XK9C88.USD","BK4550","LU1551013425.SGD","NVS","LU1929549753.HKD","LU2756315664.SGD","LU0354030511.USD","IE00B4R5TH58.HKD","LU1035775433.USD","LU0079474960.USD","BK4530","BK4581","LU0889565916.HKD","BK4196","LU0820561818.USD","LU0109394709.USD"],"gpt_icon":0},{"id":"2488657889","title":"Charles River Laboratories to Present at Evercore ISI Investor Conference","url":"https://stock-news.laohu8.com/highlight/detail?id=2488657889","media":"Business Wire","labels":["conferences"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2488657889?lang=en_us&edition=fundamental","pubTime":"2024-12-02 21:00","pubTimestamp":1733144400,"startTime":"0","endTime":"0","summary":"WILMINGTON, Mass., December 02, 2024----Charles River Laboratories International, Inc.  announced today that it will present at the 7th Annual Evercore ISI HealthCONx Conference on Wednesday, December 4th, at 10:00 a.m. ET. Management will provide an overview of Charles River’s strategic focus, business developments, and recent trends.A live webcast of the presentation will be available through a link that will be posted on the Investor Relations section of the Charles River website at ir.criver.com. A webcast replay will be accessible through the same website after the presentation and will remain available for at least two weeks.Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, ear","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/WAmxDg7D19fEdsQTJljOWA--~B/aD0zMjY7dz0xMjQ1O2FwcGlkPXl0YWNoeW9u/https://media.zenfs.com/en/business-wire.com/b048919cd7daecc0168933a48a16959a","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/WAmxDg7D19fEdsQTJljOWA--~B/aD0zMjY7dz0xMjQ1O2FwcGlkPXl0YWNoeW9u/https://media.zenfs.com/en/business-wire.com/b048919cd7daecc0168933a48a16959a"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/charles-river-laboratories-present-evercore-130000182.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"conferences","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4530","CRL","BK4585","BK4588","BK4121","LU0390134368.USD"],"gpt_icon":0},{"id":"2487056526","title":"Applied Therapeutics Stock Plummets After FDA Rejects Metabolic Disease Drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2487056526","media":"Investopedia","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2487056526?lang=en_us&edition=fundamental","pubTime":"2024-11-29 23:06","pubTimestamp":1732892804,"startTime":"0","endTime":"0","summary":"Applied Therapeutics' application for a treatment of a rare metabolic disease was rejected by the Food and Drug Administration.The FDA said the drug, govorestat for galactosemia, had \"deficiencies in the clinical application.\"The news sent shares of Applied Therapeutics plunging 75% Friday morning.Applied Therapeutics  shares cratered Friday as the biopharmaceutical firm reported that the Food and Drug Administration  rejected its application for its experimental treatment for a rare metabolic disease known as Galactosemia.The company said it had received a Complete Response Letter  from the FDA that explained that after it completed a review of the drug, govorestat, it was unable to approve Applied Therapeutics' New Drug Application  in its current form. The FDA pointed to \"deficiencies in the clinical application.\". Patients with Galactosemia cannot process the simple sugar galactose. The company noted that approximately 3,300 people in the U.S. suffer from the disease, as well as 4,","market":"hk","thumbnail":"https://www.investopedia.com/thmb/4ZZp5JvCDI3gkZJwWjUEQgA3Hbo=/3543x2362/filters:no_upscale():max_bytes(150000):strip_icc()/GettyImages-1236962131-84c386e68ae54159b31b09fc5499fa93.jpg","type":0,"news_type":0,"thumbnails":["https://www.investopedia.com/thmb/4ZZp5JvCDI3gkZJwWjUEQgA3Hbo=/3543x2362/filters:no_upscale():max_bytes(150000):strip_icc()/GettyImages-1236962131-84c386e68ae54159b31b09fc5499fa93.jpg"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.investopedia.com/applied-therapeutics-stock-plummets-after-fda-rejects-metabolic-disease-drug-8753289","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"investopedia_highlight","symbols":["BK4156","LU0109394709.USD","CEO","BK4585","LU0390134368.USD","LU0889565916.HKD","BK4121","BK4139","LU0320765992.SGD","LENZ","BK4530","BK7095","CRL","APLT","BK4588","CRL.AU"],"gpt_icon":0},{"id":"2487526805","title":"Voyager rises after upgrade, Applied plunges after CRL: Morning Movers","url":"https://stock-news.laohu8.com/highlight/detail?id=2487526805","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2487526805?lang=en_us&edition=fundamental","pubTime":"2024-11-29 21:50","pubTimestamp":1732888209,"startTime":"0","endTime":"0","summary":"Check out this morning’s top movers from around Wall Street, compiled by The Fly.  HIGHER – Voyager Therapeutics (VYGR) up 7% after Wedbush up...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/voyager-rises-after-upgrade-applied-plunges-after-crl-morning-movers?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/voyager-rises-after-upgrade-applied-plunges-after-crl-morning-movers?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["CRL"],"gpt_icon":0},{"id":"2487558037","title":"Applied Therapeutics CRL a ‘major setback,’ says William Blair","url":"https://stock-news.laohu8.com/highlight/detail?id=2487558037","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2487558037?lang=en_us&edition=fundamental","pubTime":"2024-11-29 19:40","pubTimestamp":1732880430,"startTime":"0","endTime":"0","summary":"William Blair says Applied Therapeutics (APLT)’ complete response letter from the FDA for govorestat for the treatment of galactosemia is “unexpect...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/applied-therapeutics-crl-a-major-setback-says-william-blair?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/applied-therapeutics-crl-a-major-setback-says-william-blair?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LENZ","LU0320765992.SGD","BK4121","LU0889565916.HKD","BK4585","APLT","BK4530","BK4588","BK4139","CRL","LU0109394709.USD","LU0390134368.USD"],"gpt_icon":0},{"id":"2487341096","title":"At US$200, Is It Time To Put Charles River Laboratories International, Inc. (NYSE:CRL) On Your Watch List?","url":"https://stock-news.laohu8.com/highlight/detail?id=2487341096","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2487341096?lang=en_us&edition=fundamental","pubTime":"2024-11-29 02:02","pubTimestamp":1732816973,"startTime":"0","endTime":"0","summary":"Let's talk about the popular Charles River Laboratories International, Inc. . The company's shares saw a double-digit share price rise of over 10% in the past couple of months on the NYSE. While good news for shareholders, the company has traded much higher in the past year. With many analysts covering the large-cap stock, we may expect any price-sensitive announcements have already been factored into the stock’s share price. However, what if the stock is still a bargain?Let’s examine Charles River Laboratories International’s valuation and outlook in more detail to determine if there’s still a bargain opportunity.Check out our latest analysis for Charles River Laboratories International. So while earnings quality is important, it's equally important to consid","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/dC75hPkPk1wNzUHQ29Af1A--~B/aD00MzI7dz0xMTk0O2FwcGlkPXl0YWNoeW9u/https://media.zenfs.com/en/simply_wall_st__316/2319011507a24b47a4bb11db126344d3","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/dC75hPkPk1wNzUHQ29Af1A--~B/aD00MzI7dz0xMTk0O2FwcGlkPXl0YWNoeW9u/https://media.zenfs.com/en/simply_wall_st__316/2319011507a24b47a4bb11db126344d3"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/us-200-time-put-charles-180253970.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0390134368.USD","BK4530","NYSE","BK4585","BK4588","CRL","BK4121"],"gpt_icon":0},{"id":"2487734943","title":"OTLK Stock Falls on Failure to Meet Non-Inferiority Goal in AMD Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2487734943","media":"Zacks","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2487734943?lang=en_us&edition=fundamental","pubTime":"2024-11-28 23:29","pubTimestamp":1732807740,"startTime":"0","endTime":"0","summary":"Outlook TherapeuticsOTLK reported preliminary top-line results from the 90-day non-inferiority NORSE EIGHT clinical study evaluating ONS-5010  to treat patients with wet age-related macular degeneration . The NORSE EIGHT study is the second of two adequate and well-controlled clinical studies evaluating ONS-5010 for the AMD indication.Per the data readout, the candidate failed to meet the pre-specified non-inferiority endpoint at week 8 outlined in the special protocol assessment with the FDA. ONS-5010 is an investigational ophthalmic formulation of bevacizumab, which is being developed to treat AMD and other retinal diseases. Shares of Outlook Therapeutics plunged 65.2% on Wednesday in response to the news.However, preliminary analysis of study data showed vision improvement, biological activity and a favorable safety profile for ONS-5010. Treatment with the candidate was also well-tolerated in the NORSE EIGHT study with overall ocular adverse event rates comparable to Lucentis.The sa","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/wYQLwM.yHAc_hHptSu_lhQ--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/701e76528de32ecfd8ed3df2f647e9a8","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/wYQLwM.yHAc_hHptSu_lhQ--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/701e76528de32ecfd8ed3df2f647e9a8"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/otlk-stock-falls-failure-meet-152900524.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["CRL","ALLO","IE0004445239.USD","LU1057294990.SGD","LU1803068979.SGD","BK4573","SG9999011175.SGD","BK4585","LU0985481810.HKD","LU0056508442.USD","LU0979878070.USD","LU2458330169.SGD","BK4583","BK4141","LU0889565916.HKD","GFS","LU1571399168.USD","BK4532","LU0082616367.USD","BK4568","IE00BBT3K403.USD","BK4554","BK4529","LU0109392836.USD","PFE","LU1852331112.SGD","GILD","LU1988902786.USD","LU0109394709.USD","IE00BZ1G4Q59.USD","OTLK","LU0321505868.SGD","IE00BMPRXN33.USD","LU1894683348.USD","IE00B19Z3581.USD","BK4578","LU1585245621.USD","LU1839511570.USD","LU1303367103.USD","IE00BLSP4452.SGD","BK4505","BK4599","LU0198837287.USD","LU2250418816.HKD","LU0058720904.USD","BK4530","LU0390134368.USD","LU0823434740.USD","LU0170899867.USD"],"gpt_icon":1},{"id":"2487345384","title":"APLT Stock Plunges 77% After FDA Issues CRL for Galactosemia Drug NDA","url":"https://stock-news.laohu8.com/highlight/detail?id=2487345384","media":"Zacks","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2487345384?lang=en_us&edition=fundamental","pubTime":"2024-11-28 23:13","pubTimestamp":1732806780,"startTime":"0","endTime":"0","summary":"Applied TherapeuticsAPLT announced that the FDA has issued a Complete Response Letter  for the new drug application  seeking approval for APLT’s lead candidate, govorestat, to treat classic galactosemia. The CRL stated that the FDA has reviewed the application and cannot approve the NDA in its current form due to deficiencies in the clinical study results submitted in support of the application.Applied Therapeutics isevaluating the FDA's feedback. It intends to promptly request a meeting to discuss the requirements for a potential NDA resubmission or appeal of the decision, and appropriate next steps. Shares of the company tanked 77.3% in the after-market hours, following the disappointing news.APLT’s govorestat  is a novel central nervous system penetrant ARI, which is currently being developed for three rare neurological diseases. The NDA for govorestat for the galactosemia indication was accepted by the FDA in late February under its Priority Review pathway.Year to date, shares of A","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/T8SwUImUDIjgxL38j1nI4w--~B/aD00MTQ7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/17664ed95646b97db9beb170298a16b3","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/T8SwUImUDIjgxL38j1nI4w--~B/aD00MTQ7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/17664ed95646b97db9beb170298a16b3"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/aplt-stock-plunges-77-fda-151300400.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4139","LU0234572021.USD","LU1066051498.USD","SG9999011175.SGD","SGXZ57979304.SGD","LU2087621335.USD","IE00BBT3K403.USD","LU0170899867.USD","LU0289739699.SGD","LU0321505439.SGD","BK4583","BK4592","BK4550","BK4599","LU0985481810.HKD","IE00BSNM7G36.USD","LU1894683264.USD","LU1883839398.USD","APLT","SG9999002224.SGD","IE00B19Z3B42.SGD","LU0058720904.USD","LU1057294990.SGD","LU1571399168.USD","SG9999001176.USD","SG9999013999.USD","ALLO","IE00BZ1G4Q59.USD","BK4581","PFE","BK4534","BK4007","BK4588","IE00B19Z3581.USD","LU0320765992.SGD","SG9999001176.SGD","GILD","BK4505","LU0234570918.USD","LU0321505868.SGD","LU0868494617.USD","BK4578","CRL","LU1023059063.AUD","LU1430594728.SGD","LU0456855351.SGD","BK4566","BK4121","LU0225771236.USD","BK4532"],"gpt_icon":1},{"id":"2486190753","title":"French firm joins SBS Transit to win Jurong Region Line contract; first foreign operator in Singapore rail","url":"https://stock-news.laohu8.com/highlight/detail?id=2486190753","media":"CNA","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2486190753?lang=en_us&edition=fundamental","pubTime":"2024-11-28 20:39","pubTimestamp":1732797540,"startTime":"0","endTime":"0","summary":"The joint venture - between SBS Transit Rail and a subsidiary of French public transport operator RATP Dev - beat SMRT Trains to win the contract for Jurong Region Line.","market":"sg","thumbnail":"https://onecms-res.cloudinary.com/image/upload/s--5XmEir1p--/c_crop,h_540,w_960,x_0,y_0/c_fill,g_auto,h_468,w_830/f_auto,q_auto/jrl-js9-mrt-station.png?itok=MOg3XWZ1","type":0,"news_type":0,"thumbnails":["https://onecms-res.cloudinary.com/image/upload/s--5XmEir1p--/c_crop,h_540,w_960,x_0,y_0/c_fill,g_auto,h_468,w_830/f_auto,q_auto/jrl-js9-mrt-station.png?itok=MOg3XWZ1"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.channelnewsasia.com/singapore/jurong-region-line-sbs-transit-rail-ratp-dev-srjv-joint-venture-operator-contract-4776316","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"can_highlight","symbols":["BK4121","SBS","BK4588","BK4172","CRL","BK4530","LU0390134368.USD","BK4585"],"gpt_icon":0}],"pageSize":16,"totalPage":13,"pageCount":12,"totalSize":200}]}}