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Denali Therapeutics Inc.

19.53

-0.5350-2.67%

Volume:655.91K

Turnover:12.77M

Market Cap:3.10B

PE:-6.57

High:20.09

Open:19.85

Low:18.95

Close:20.06

52wk High:23.77

52wk Low:10.57

Shares:158.59M

Float Shares:144.00M

Volume Ratio:0.80

T/O Rate:0.46%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.9700

EPS(LYR):-2.9700

ROE:-45.69%

ROA:-27.56%

PB:3.05

PE(LYR):-6.57

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Overview Company News Filings

Centessa Pharmaceuticals, CG Oncology Drive Q3 Biotech Momentum, Morgan Stanley Says

MT Newswires Live

Can Denali Therapeutics (DNLI)’s New Leadership Steady the Narrative Amid Mounting Losses?

Simply Wall St.

Stock Track | Denali Therapeutics Soars 5.33% Pre-Market on Oppenheimer's Buy Rating

Oppenheimer Sticks to Its Buy Rating for Denali Therapeutics (DNLI)

Denali Therapeutics Inc. Files Initial Statement of Beneficial Ownership for Director Timothy Van Hauwermeiren

Denali Therapeutics Q3 net loss widens to $126.9 mln

Denali Therapeutics reports third quarter net loss of $126.9 million

BRIEF-Denali Therapeutics Q3 Operating Expenses USD 137.434 Million

Denali Therapeutics Appoints Tim Van Hauwermeiren to Board and Names Peter Chin Acting Chief Medical Officer

Press Release: Denali Therapeutics Announces Board and Executive Leadership Updates

Denali Therapeutics (DNLI) Gets a Buy from J.P. Morgan

U.S. RESEARCH ROUNDUP-Affiliated Managers Group, Argenx, Cardinal Health

Denali Therapeutics Inc expected to post a loss of 75 cents a share - Earnings Preview

Wedbush Keeps Their Buy Rating on Denali Therapeutics (DNLI)

Denali Therapeutics announces FDA extension of tividenofusp BLA review timeline

Denali Therapeutics Announces FDA Review Extension for Tividenofusp Alfa in Hunter Syndrome; New PDUFA Date Set for April 2026

Denali Therapeutics Inc - Pdufa Date Extended to April 5, 2026

THOMSON REUTERS

Denali Therapeutics Announces FDA Review Extension of Bla for Tividenofusp Alfa for the Treatment of Mps Ii (Hunter Syndrome)

THOMSON REUTERS

Denali Therapeutics Inc: Believes Updated Information Submitted in Amendment Does Not Affect Clinical Pharmacology or Benefit-Risk Conclusions of Bla

THOMSON REUTERS

Denali Therapeutics Inc: No Additional Data Were Requested by FDA in Ma Letter

THOMSON REUTERS

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confidence","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["LU1244550577.SGD","BK4539","BK4611","LU1162221912.USD","CG","LU1668664300.SGD","LU1244550494.USD","LU0106261372.USD","IE00BGHQF748.EUR","IE00BZ1G4Q59.USD","LU1732800096.USD","LU1732799900.SGD","IE00B3QW5Z07.USD","BK4535","CNTA","LU2133065610.SGD","LU1720051108.HKD","LU0006306889.USD","BK4534","LU0106831901.USD","LU2023251221.USD","LU0882574139.USD","LU2111349929.HKD","DNLI","CGON","LU1074936037.SGD","LU2028103732.USD","LU1244550221.USD","IE00B64PRP62.GBP","IE00BKVL7J92.USD","CTNM","BK4585","LU0557290698.USD","LU0971096721.USD","BK4504","LU2347655156.SGD","LU0267386448.USD","BK4516","BK4127","LU0795875169.SGD","LU2089284900.SGD","LU0795875086.SGD","LU1720051017.SGD","LU1989772840.SGD","BK4139","LU0098860793.USD","LU0234570918.USD","BK4007","BK4609"],"gpt_icon":1},{"id":"2583910662","title":"Can Denali Therapeutics (DNLI)’s New Leadership Steady the Narrative Amid Mounting Losses?","url":"https://stock-news.laohu8.com/highlight/detail?id=2583910662","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2583910662?lang=en_us&edition=fundamental","pubTime":"2025-11-16 19:21","pubTimestamp":1763292066,"startTime":"0","endTime":"0","summary":"Denali Therapeutics recently announced significant leadership changes, with Chief Medical Officer Carole Ho departing for Eli Lilly, Peter Chin appointed as Acting Chief Medical Officer, and seasoned executive Tim Van Hauwermeiren joining the Board of Directors.\nThese executive transitions come as the company reported higher net losses for both the third quarter and nine months ended September 30, 2025, increasing market attention on Denali’s future direction and stability.\nWe’ll explore how...","market":"hk","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-dnli/denali-therapeutics/news/can-denali-therapeutics-dnlis-new-leadership-steady-the-narr","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-dnli/denali-therapeutics/news/can-denali-therapeutics-dnlis-new-leadership-steady-the-narr","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4535","BK4548","BK4139","DNLI"],"gpt_icon":0},{"id":"1197631610","title":"Stock Track | Denali Therapeutics Soars 5.33% Pre-Market on Oppenheimer's Buy Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=1197631610","media":"Stock Track","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1197631610?lang=en_us&edition=fundamental","pubTime":"2025-11-10 22:49","pubTimestamp":1762786155,"startTime":"0","endTime":"0","summary":"Denali Therapeutics Inc. (DNLI) stock is soaring 5.33% in pre-market trading on Monday, following Oppenheimer analyst Jay Olson's reaffirmation of a Buy rating for the company. The analyst has set a...","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":"ai_movement_en","symbols":["DNLI"],"gpt_icon":0},{"id":"2582724018","title":"Oppenheimer Sticks to Its Buy Rating for Denali Therapeutics (DNLI)","url":"https://stock-news.laohu8.com/highlight/detail?id=2582724018","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2582724018?lang=en_us&edition=fundamental","pubTime":"2025-11-10 22:18","pubTimestamp":1762784285,"startTime":"0","endTime":"0","summary":"Oppenheimer analyst Jay Olson maintained a Buy rating on Denali Therapeutics today and set a price target of $35.00. According to TipRanks, Olson i...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/oppenheimer-sticks-to-its-buy-rating-for-denali-therapeutics-dnli-blurbs-2?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/oppenheimer-sticks-to-its-buy-rating-for-denali-therapeutics-dnli-blurbs-2?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["OPY","DNLI"],"gpt_icon":0},{"id":"2581028255","title":"Denali Therapeutics Inc. Files Initial Statement of Beneficial Ownership for Director Timothy Van Hauwermeiren","url":"https://stock-news.laohu8.com/highlight/detail?id=2581028255","media":"Reuters","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581028255?lang=en_us&edition=fundamental","pubTime":"2025-11-07 09:16","pubTimestamp":1762478193,"startTime":"0","endTime":"0","summary":"Denali Therapeutics Inc. has filed an initial statement of beneficial ownership with the U.S. Securities and Exchange Commission. The filing lists Timothy Van Hauwermeiren as a Director and the beneficial owner. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Denali Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on November 06, 2025, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251107:nNDL1jBWkg:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4535","BK4548","DNLI","BK4139"],"gpt_icon":0},{"id":"2581045849","title":"Denali Therapeutics Q3 net loss widens to $126.9 mln","url":"https://stock-news.laohu8.com/highlight/detail?id=2581045849","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581045849?lang=en_us&edition=fundamental","pubTime":"2025-11-07 05:40","pubTimestamp":1762465221,"startTime":"0","endTime":"0","summary":"Denali Therapeutics Q3 net loss widens to $126.9 mlnOverviewDenali Q3 net loss widens to $126.9 mln from $107.2 mln last yearOperating expenses increased due to R&D and commercial launch preparationsF","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251106:nL1N3WI1IT:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","DNLI","BK4548","BK4535"],"gpt_icon":0},{"id":"2581017054","title":"Denali Therapeutics reports third quarter net loss of $126.9 million","url":"https://stock-news.laohu8.com/highlight/detail?id=2581017054","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581017054?lang=en_us&edition=fundamental","pubTime":"2025-11-07 05:06","pubTimestamp":1762463185,"startTime":"0","endTime":"0","summary":"Denali Therapeutics Inc. reported a net loss of $126.9 million for the third quarter ended September 30, 2025, compared to a net loss of $107.2 million for the same period in 2024. Total research and development expenses were $102.0 million, up from $98.2 million in the prior year quarter, with increases driven by new operations at the company's large molecule manufacturing facility in Salt Lake City, Utah. The company highlighted continued engagement with the FDA regarding the tividenofusp alfa BLA review for MPS II and completed enrollment in the DNL126 Phase 1/2 study for MPS IIIA. Denali also submitted regulatory applications to begin clinical studies with DNL628 for Alzheimer's disease and DNL952 for Pompe disease. Leadership changes include Peter Chin, M.D., assuming the role of Acting Chief Medical Officer following the departure of Carole Ho, M.D.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251106:nNDLBVYF7:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["DNLI","BK4548","BK4535","BK4139"],"gpt_icon":0},{"id":"2581101279","title":"BRIEF-Denali Therapeutics Q3 Operating Expenses USD 137.434 Million","url":"https://stock-news.laohu8.com/highlight/detail?id=2581101279","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581101279?lang=en_us&edition=fundamental","pubTime":"2025-11-07 05:01","pubTimestamp":1762462909,"startTime":"0","endTime":"0","summary":"BRIEF-Denali Therapeutics Q3 Operating Expenses USD 137.434 Million\n\n\nNov 06 (Reuters) - Denali Therapeutics Q3 operating income USD -137.434 million.\n\nQ3 basic EPS USD -0.74\nQ3 net income USD -126.902 million","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251106:nPLX0DC891:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4548","BK4535","DNLI","BK4139"],"gpt_icon":0},{"id":"2581121270","title":"Denali Therapeutics Appoints Tim Van Hauwermeiren to Board and Names Peter Chin Acting Chief Medical Officer","url":"https://stock-news.laohu8.com/highlight/detail?id=2581121270","media":"Reuters","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581121270?lang=en_us&edition=fundamental","pubTime":"2025-11-07 05:00","pubTimestamp":1762462848,"startTime":"0","endTime":"0","summary":"Denali Therapeutics Inc. announced changes to its executive leadership and board. Tim Van Hauwermeiren, co-founder and CEO of argenx, has joined Denali's Board of Directors. Carole Ho, M.D., Chief Medical Officer and Head of Development, will depart to join Eli Lilly and Company. Peter Chin, M.D., previously Senior Vice President of the Enzyme TransportVehicle Franchise and Late-Stage Clinical Development, has been appointed Acting Chief Medical Officer and Head of Development.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Denali Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire  on November 06, 2025, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251106:nNDL8N9ctF:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SG9999014898.SGD","LU2491050071.SGD","IE00BK4W5L77.USD","LU2237443978.SGD","IE00B64PRP62.GBP","LU0238689110.USD","BK4599","SGXZ99366536.SGD","SG9999015952.SGD","LU2089984988.USD","LU1720051017.SGD","LU0823434740.USD","LU2210150020.SGD","LU1093756325.SGD","IE00B1BXHZ80.USD","BK4535","DNLI","BK4516","IE00B3QW5Z07.USD","IE00BGHQF748.EUR","LU0114720955.EUR","LU1974910355.USD","IE0002141913.USD","LU1267930730.SGD","LU2211815571.USD","LU2237443549.SGD","BK4581","LU0708995401.HKD","LU1057294990.SGD","LU1868836757.USD","LU2237443622.USD","NDAQ","LU0058720904.USD","SG9999018865.SGD","SG9999001176.USD","LU2095319765.USD","LU0006306889.USD","LU2106854487.HKD","LU2491049909.HKD","BK4548","LU1814569148.SGD","BK4139","LU2357305700.SGD","LU0689472784.USD","SG9999015978.USD","LU0353189680.USD","LU0820561818.USD","LU1720051108.HKD","IE00B4R5TH58.HKD"],"gpt_icon":1},{"id":"2581189017","title":"Press Release: Denali Therapeutics Announces Board and Executive Leadership Updates","url":"https://stock-news.laohu8.com/highlight/detail?id=2581189017","media":"Dow Jones","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581189017?lang=en_us&edition=fundamental","pubTime":"2025-11-07 05:00","pubTimestamp":1762462800,"startTime":"0","endTime":"0","summary":"SOUTH SAN FRANCISCO, Calif., Nov. 06, 2025  -- Denali Therapeutics Inc.  today announced updates to its Board of Directors and executive leadership team.Tim Van Hauwermeiren has been appointed to Denali's Board of Directors. Mr. Van Hauwermeiren is co-founder and Chief Executive Officer of argenx. Carole Ho, M.D., who has served as Denali's Chief Medical Officer and Head of Development since 2015, will be departing to join Eli Lilly and Company as Executive Vice President, and President of Lilly Neuroscience. Peter Chin, M.D., is assuming the role of Acting Chief Medical Officer and Head of Development at Denali. Dr. Chin is a neurologist and joined Denali in 2019, most recently serving as Senior Vice President of the Enzyme TransportVehicle  Franchise and Late-Stage Clinical Development.\"I am deeply grateful for the trust placed in me to lead","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4555","DNLI","BK4100","BBB","BK4007","BK4585","ETV","BK4588","BK4604","03160","BK4099","TM","BK4548","LENZ","TV","BK4535","BK4539","BK4139"],"gpt_icon":0},{"id":"2581724542","title":"Denali Therapeutics (DNLI) Gets a Buy from J.P. 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