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Fulcrum Therapeutics

7.65

+0.02000.26%

Post-market: 7.650.00000.00%16:10 EDT

Volume:536.83K

Turnover:4.05M

Market Cap:509.49M

PE:-6.47

High:7.83

Open:7.63

Low:7.34

Close:7.63

52wk High:15.74

52wk Low:2.32

Shares:66.60M

Float Shares:39.39M

Volume Ratio:0.56

T/O Rate:1.36%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-1.1819

EPS(LYR):-1.1819

ROE:-25.30%

ROA:-16.90%

PB:1.46

PE(LYR):-6.47

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Overview Company News Filings

Chief Legal Officer Curt Oltmans Reports Sale of Fulcrum Therapeutics Common Shares

Fulcrum Therapeutics Is Maintained at Buy by Truist Securities

RA Capital Management Reports Sale of Fulcrum Therapeutics Common Shares

BRIEF-Fulcrum Therapeutics Announces Pricing Of Upsized $175.0 Million Public Offering Of Common Stock And Pre-Funded Warrants

Fulcrum Therapeutics Inc - Prices Public Offering of 11.85 Mln Shares at $13.50

THOMSON REUTERS

Fulcrum Therapeutics Is Maintained at Underperform by B of A Securities

BUZZ-Fulcrum Therapeutics dips after unveiling $150 million share sale

Press Release: Fulcrum Therapeutics Announces Proposed $150.0 Million Public Offering of Common Stock

BUZZ-U.S. STOCKS ON THE MOVE-Five Below, Boeing, Instacart

Fulcrum Therapeutics Up Nearly 59%, on Pace for Largest Percent Increase Since August 2021 -- Data Talk

BUZZ-U.S. STOCKS ON THE MOVE-Micron, NextEra Energy, Ocular Therapeutix

BUZZ-Fulcrum Therapeutics rises after trial data of blood disorder drug

Fulcrum Therapeutics Is Maintained at Buy by HC Wainwright & Co.

Fulcrum Therapeutics Shares up 49.1% Premarket After Positive Early-Stage Trial Data of Blood Disorder Drug

THOMSON REUTERS

RBC Raises Price Target on Fulcrum Therapeutics to $10 From $7, Keeps Sector Perform, Speculative Risk

MT Newswires Live

Fulcrum Therapeutics Inc : Leerink Partners Raises Target Price to $24 From $20

THOMSON REUTERS

Fulcrum Shares Soar on Sickle-Cell Treatment Trial Results

Fulcrum Therapeutics Reports Positive Initial Results from Trial of Pociredir in Sickle Cell Disease; Shares Surge Pre-Bell

MT Newswires Live

Fulcrum Therapeutics Reports Positive Phase 1b Results for Pociredir in Sickle Cell Disease

Fulcrum Therapeutics Announces Positive Initial Results From the 20 Mg Dose Cohort of the Phase 1B Pioneer Trial of Pociredir in Sickle Cell Disease at the 67TH American Society of Hematology Annual Meeting

THOMSON REUTERS

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Legal Officer Curt Oltmans Reports Sale of Fulcrum Therapeutics Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2592943972","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592943972?lang=en_us&edition=fundamental","pubTime":"2025-12-18 05:10","pubTimestamp":1766005829,"startTime":"0","endTime":"0","summary":"Curtis Gale Oltmans, Chief Legal Officer of Fulcrum Therapeutics Inc., reported a disposal of common shares of Fulcrum Therapeutics Inc. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Fulcrum Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on December 17, 2025, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251217:nNDL9Dvpk0:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":"Chief Legal Officer Curt Oltmans Reports Sale of Fulcrum Therapeutics Common Shares","news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["FULC","BK4007"],"gpt_icon":0},{"id":"2590543937","title":"Fulcrum Therapeutics Is Maintained at Buy by Truist Securities","url":"https://stock-news.laohu8.com/highlight/detail?id=2590543937","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590543937?lang=en_us&edition=fundamental","pubTime":"2025-12-12 01:57","pubTimestamp":1765475820,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/FULC/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 11, 2025 12:57 ET (17:57 GMT)","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["FULC"],"gpt_icon":0},{"id":"2590553791","title":"RA Capital Management Reports Sale of Fulcrum Therapeutics Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2590553791","media":"Reuters","labels":["insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590553791?lang=en_us&edition=fundamental","pubTime":"2025-12-11 05:43","pubTimestamp":1765403008,"startTime":"0","endTime":"0","summary":"RA Capital Management, L.P. has reported a disposal of common shares of Fulcrum Therapeutics Inc., according to a recent SEC filing. The transaction was reported by multiple beneficial owners, including Peter Kolchinsky and Rajeev M. Shah, among other reporting beneficial owners. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Fulcrum Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on December 10, 2025, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251210:nNDL359f8y:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"RA Capital Management Reports Sale of Fulcrum Therapeutics Common Shares","news_tag":"insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","FULC"],"gpt_icon":0},{"id":"2590458265","title":"BRIEF-Fulcrum Therapeutics Announces Pricing Of Upsized $175.0 Million Public Offering Of Common Stock And Pre-Funded Warrants","url":"https://stock-news.laohu8.com/highlight/detail?id=2590458265","media":"Reuters","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590458265?lang=en_us&edition=fundamental","pubTime":"2025-12-10 20:49","pubTimestamp":1765370973,"startTime":"0","endTime":"0","summary":"BRIEF-Fulcrum Therapeutics Announces Pricing Of Upsized $175.0 Million Public Offering Of Common Stock And Pre-Funded WarrantsDec 10 (Reuters) - Fulcrum Therapeutics Inc FULC.O:FULCRUM THERAPEUTICS AN","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251210:nTUAC1RDRT:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","FULC"],"gpt_icon":0},{"id":"2590523582","title":"Fulcrum Therapeutics Inc - Prices Public Offering of 11.85 Mln Shares at $13.50","url":"https://stock-news.laohu8.com/highlight/detail?id=2590523582","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590523582?lang=en_us&edition=fundamental","pubTime":"2025-12-10 20:48","pubTimestamp":1765370909,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251210:nTUAC1RDRT:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4007","FULC"],"gpt_icon":0},{"id":"2590325495","title":"Fulcrum Therapeutics Is Maintained at Underperform by B of A Securities","url":"https://stock-news.laohu8.com/highlight/detail?id=2590325495","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590325495?lang=en_us&edition=fundamental","pubTime":"2025-12-10 02:04","pubTimestamp":1765303440,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/FULC/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 09, 2025 13:04 ET (18:04 GMT)","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["FULC"],"gpt_icon":0},{"id":"2590364342","title":"BUZZ-Fulcrum Therapeutics dips after unveiling $150 million share sale","url":"https://stock-news.laohu8.com/highlight/detail?id=2590364342","media":"Reuters","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590364342?lang=en_us&edition=fundamental","pubTime":"2025-12-09 07:29","pubTimestamp":1765236598,"startTime":"0","endTime":"0","summary":"BUZZ-Fulcrum Therapeutics dips after unveiling $150 million share sale** Shares of drug developer Fulcrum Therapeutics FULC.O fall 1.8% to $12.75 in extended trading** FULC kicks off public offering of $150 million worth of shares** Stock closed 46% higher on Monday after FULC unveiled trial data of blood disorder drug** J.P. Morgan, Leerink Partners, and Cantor are book-running managers for offering** Proceeds will be used for general purposes, including research and development and to fund clinical trials, among other purposes** 7 of 9 brokerages rate the stock \"buy\" or higher, one \"hold\" and one \"sell\"; median PT $20 - data compiled by LSEG** As of last close, FULC up 176.4% YTD  ","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251208:nL6N3XE14L:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4207","MNSH","BK4007","FULC"],"gpt_icon":0},{"id":"2590365688","title":"Press Release: Fulcrum Therapeutics Announces Proposed $150.0 Million Public Offering of Common Stock","url":"https://stock-news.laohu8.com/highlight/detail?id=2590365688","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590365688?lang=en_us&edition=fundamental","pubTime":"2025-12-09 05:01","pubTimestamp":1765227660,"startTime":"0","endTime":"0","summary":"CAMBRIDGE, Mass., Dec. 08, 2025  -- Fulcrum Therapeutics, Inc.  , a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases, today announced that it has commenced an underwritten public offering of $150.0 million of shares of its common stock. Fulcrum also intends to grant the underwriters a 30-day option to purchase up to an additional $22.5 million of shares of its common stock offered in the proposed public offering. All of the shares in the proposed offering are to be sold by Fulcrum.Fulcrum currently intends to use the net proceeds from the sale of securities offered in the proposed public offering primarily for general corporate purposes, which may include working capital and capital expenditures, research and development expenses, including to fund clinical trials, regulatory submissions, commercialization, discovery and additional preclinical research and development of additional 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STXBZThe Day Ahead newsletter: https://refini.tv/3LI4BU7The Morning News Call newsletter: http","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251208:nL6N3XE0MP:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["RIOT","XOM","LNG","JEF","BKR","OMF","NRIX","COP","MMM","COMP","EXE","FCX","FIVE","ALB","DYN","EOG","SCCO","INCY","APD","WBD","AR","CFLT","USCB","APA","GM","OCUL","WYNN","CVX","ACLX","KYMR","AGIO","FULC","FANG","CRH","GPCR","LEN","HUT","NEE","TPL","ROK"],"gpt_icon":1},{"id":"2590835255","title":"Fulcrum Therapeutics Up Nearly 59%, on Pace for Largest Percent Increase Since August 2021 -- Data Talk","url":"https://stock-news.laohu8.com/highlight/detail?id=2590835255","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590835255?lang=en_us&edition=fundamental","pubTime":"2025-12-09 00:13","pubTimestamp":1765210380,"startTime":"0","endTime":"0","summary":"Fulcrum Therapeutics, Inc.  is currently at $14.13, up $5.23 or 58.76%. --Would be highest close since April 12, 2022, when it closed at $16.39. --On pace for largest percent increase since Aug. 10, 2021, when it rose 125.33%. --Currently up two consecutive days; up 61.3% over this period. --Up 200.64% year-to-date; on pace for best year on record . --Down 54.38% from its all-time closing high of $30.97 on Sept. 20, 2021. --Up 252.37% from 52 weeks ago , when it closed at $4.01. --Up 462.95% from its 52-week closing low of $2.51 on April 4, 2025. --Traded as high as $14.87; highest intraday level since Jan. 13, 2023, when it hit $15.00. --Up 67.08% at today's intraday high; largest intraday percent increase since Aug. 10, 2021, when it rose as much as 165.18%","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["FULC","BK4007"],"gpt_icon":0},{"id":"2589359780","title":"BUZZ-U.S. STOCKS ON THE MOVE-Micron, NextEra Energy, Ocular Therapeutix","url":"https://stock-news.laohu8.com/highlight/detail?id=2589359780","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589359780?lang=en_us&edition=fundamental","pubTime":"2025-12-08 22:34","pubTimestamp":1765204451,"startTime":"0","endTime":"0","summary":"BUZZ-U.S. STOCKS ON THE MOVE-Micron, NextEra Energy, Ocular TherapeutixEikon search string for individual stock moves: STXBZThe Day Ahead newsletter: https://refini.tv/3LI4BU7The Morning News Call new","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251208:nL6N3XE0MO:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU0661504455.SGD","COMP","APA","FANG","LEN","RIOT","SCCO","RIO.UK","HUT","CVNA","CFLT","WVE","COP","AGIO","MMM","OCUL","ALB","JEF","LU1261432733.SGD","EOG","NEE","ACLX","BK4539","WYNN","FULC","KYMR","USCB","GPCR","IBM","FCX","AR","BHP.AU","CRH","DYN","GM","RIO.AU","MU","TSYW.SI","INCY"],"gpt_icon":1},{"id":"2589353100","title":"BUZZ-Fulcrum Therapeutics rises after trial data of blood disorder drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2589353100","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589353100?lang=en_us&edition=fundamental","pubTime":"2025-12-08 21:12","pubTimestamp":1765199557,"startTime":"0","endTime":"0","summary":"BUZZ-Fulcrum Therapeutics rises after trial data of blood disorder drug** Shares of drug developer Fulcrum Therapeutics FULC.O jump 49.4% to $13.30 premarket ** Flucrum said on Sunday its experimental drug showed positive results in patients with sickle cell disease from an ongoing 20 dose cohort of an early-stage trial ** Sickle cell disease is an inherited blood disorder that affects the hemoglobin in red blood cells** In a 12-patient study, the company is testing the safety and efficacy of its experimental drug, pociredir, an oral once-daily HbF inducer** FULC says every patients in the study experienced a significant rise in fetal hemoglobin  levels after treatment** Company plans to re-engage with the FDA in H1 2026** RBC Capital Markets says it remains on the sidelines, awaiting further regulatory clarity around Fulcrum Therapeutics' development plans** \"We think it will be important to see... whether regulators will allow FULC to move directly into a pivotal trial or ask for an ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251208:nL4N3XE0X1:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","FULC"],"gpt_icon":0},{"id":"2589535846","title":"Fulcrum Therapeutics Is Maintained at Buy by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2589535846","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589535846?lang=en_us&edition=fundamental","pubTime":"2025-12-08 20:50","pubTimestamp":1765198200,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/FULC/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 08, 2025 07:50 ET (12:50 GMT)","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["FULC"],"gpt_icon":0},{"id":"2589358980","title":"Fulcrum Therapeutics Shares up 49.1% Premarket After Positive Early-Stage Trial Data of Blood Disorder Drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2589358980","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589358980?lang=en_us&edition=fundamental","pubTime":"2025-12-08 20:44","pubTimestamp":1765197897,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251208:nL4N3XE0VT:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4007","FULC"],"gpt_icon":0},{"id":"2589035833","title":"RBC Raises Price Target on Fulcrum Therapeutics to $10 From $7, Keeps Sector Perform, Speculative Risk","url":"https://stock-news.laohu8.com/highlight/detail?id=2589035833","media":"MT Newswires Live","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589035833?lang=en_us&edition=fundamental","pubTime":"2025-12-08 20:37","pubTimestamp":1765197438,"startTime":"0","endTime":"0","summary":"Fulcrum Therapeutics (FULC) has an average rating of overweight and mean price target of $16.89, according to analysts polled by FactSet.(MT Newswires covers equity, commodity and economic research fr","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate","earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"express","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["FULC"],"gpt_icon":0},{"id":"2589370633","title":"Fulcrum Therapeutics Inc : Leerink Partners Raises Target Price to $24 From $20","url":"https://stock-news.laohu8.com/highlight/detail?id=2589370633","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589370633?lang=en_us&edition=fundamental","pubTime":"2025-12-08 20:03","pubTimestamp":1765195419,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251208:nFWN3XE0QC:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4007","FULC"],"gpt_icon":0},{"id":"2589808337","title":"Fulcrum Shares Soar on Sickle-Cell Treatment Trial Results","url":"https://stock-news.laohu8.com/highlight/detail?id=2589808337","media":"Dow Jones","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589808337?lang=en_us&edition=fundamental","pubTime":"2025-12-08 19:42","pubTimestamp":1765194120,"startTime":"0","endTime":"0","summary":"Shares of Fulcrum Therapeutics soared after the company released positive initial results from a trial of its pociredir drug to treat sickle-cell disease.The stock rose 47% to $13.06 in premarket trading. Shares were up 89% this year as of Friday.The clinical-stage biopharmaceutical company late Saturday said initial results from the 20-milligram dose cohort of the trial showed robust and clinically meaningful increases in fetal hemoglobin.Fulcrum, based in Cambridge, Mass., also said the drug continued showing a favorable safety profile with no treatment-related severe adverse events reported.","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":"Fulcrum Shares Soar on Sickle-Cell Treatment Trial Results","news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","FULC"],"gpt_icon":0},{"id":"2589332400","title":"Fulcrum Therapeutics Reports Positive Initial Results from Trial of Pociredir in Sickle Cell Disease; Shares Surge Pre-Bell","url":"https://stock-news.laohu8.com/highlight/detail?id=2589332400","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589332400?lang=en_us&edition=fundamental","pubTime":"2025-12-08 19:31","pubTimestamp":1765193477,"startTime":"0","endTime":"0","summary":"Fulcrum Therapeutics  on Saturday reported positive initial results from its ongoing 20 mg dose cohort of the phase 1b PIONEER trial of pociredir in adult patients with sickle cell disease.The company said that it observed clear dose-response, with a robust and clinically meaningful fetal hemoglobin induction at week 6 and mean absolute fetal hemoglobin in the 20 mg cohort increasing 9.9% at week 6 versus 5.6% in the 12 mg cohort.The company further said that pociredir continued to be generally well-tolerated, with no treatment-related serious adverse events.Fulcrum Therapeutics' share price jumped over 63% in recent Monday premarket activity.Price: 14.55, Change: +5.65, Percent Change: +63.48","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4007","FULC"],"gpt_icon":0},{"id":"2589822050","title":"Fulcrum Therapeutics Reports Positive Phase 1b Results for Pociredir in Sickle Cell Disease","url":"https://stock-news.laohu8.com/highlight/detail?id=2589822050","media":"Reuters","labels":["dataReport","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589822050?lang=en_us&edition=fundamental","pubTime":"2025-12-07 06:30","pubTimestamp":1765060216,"startTime":"0","endTime":"0","summary":"Fulcrum Therapeutics Inc. announced positive initial results from the 20 mg dose cohort of the Phase 1b PIONEER trial evaluating pociredir in patients with sickle cell disease. The interim analysis showed a dose-response relationship, with a mean absolute increase in fetal hemoglobin  of 9.9% at Week 6 in the 20 mg cohort, compared to 5.6% in the 12 mg cohort. At Week 6, 58% of patients in the 20 mg cohort achieved absolute HbF levels of 20% or higher. Among patients who reached the Week 12 visit, the 20 mg cohort demonstrated a greater than 3.75-fold mean induction of HbF. Pociredir was generally well-tolerated with no treatment-related serious adverse events reported. These results were presented at the 67th American Society of Hematology Annual Meeting, and Fulcrum Therapeutics will host an investor event on December 7, 2025, to further discuss the data.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251206:nNDL2QZZPZ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","BK4112","BK4585","SG9999014005.SGD","SG9999014013.SGD","FULC","IE00B3QW5Z07.USD","BK4588","LU2210150020.SGD","LU0314104364.USD","IE00B64PRP62.GBP","NDAQ","IE00BKPKM429.USD","SG9999014021.USD","IE00BGHQF748.EUR","LU2210149790.SGD","LU2095319765.USD"],"gpt_icon":0},{"id":"2589822069","title":"Fulcrum Therapeutics Announces Positive Initial Results From the 20 Mg Dose Cohort of the Phase 1B Pioneer Trial of Pociredir in Sickle Cell Disease at the 67TH American Society of Hematology Annual Meeting","url":"https://stock-news.laohu8.com/highlight/detail?id=2589822069","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589822069?lang=en_us&edition=fundamental","pubTime":"2025-12-07 06:30","pubTimestamp":1765060202,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251206:nTUA4JMM9Q:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4007","FULC"],"gpt_icon":0}],"pageSize":20,"totalPage":6,"pageCount":3,"totalSize":105,"code":"91000000","status":"200"}]}}