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Ionis Pharmaceuticals

72.69

+0.35000.48%

Volume:1.12M

Turnover:81.58M

Market Cap:12.01B

PE:-30.54

High:73.29

Open:72.35

Low:71.92

Close:72.34

52wk High:86.74

52wk Low:23.95

Shares:165.19M

Float Shares:164.00M

Volume Ratio:0.57

T/O Rate:0.68%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.3800

EPS(LYR):-2.3812

ROE:-70.80%

ROA:-7.31%

PB:24.55

PE(LYR):-30.53

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Overview Company News Filings

Ionis Pharmaceuticals announces Phase 3 CORE, CORE2 met primary endpoint

Ionis Pharmaceuticals Unveils Positive Olezarsen Study Results for sHTG Treatment

Analysts Offer Insights on Healthcare Companies: Ionis Pharmaceuticals (IONS) and Immunocore Holdings (IMCR)

Olezarsen Achieves Up to 72% Triglyceride Reduction in Phase 3 sHTG Trials

Ionis Pharmaceuticals EVP Brian Birchler Reports Sale of Common Shares

William Blair Reaffirms Their Buy Rating on Ionis Pharmaceuticals (IONS)

Ionis Pharmaceuticals Is Maintained at Overweight by Piper Sandler

U.S. RESEARCH ROUNDUP-Affiliated Managers Group, Argenx, Cardinal Health

Ionis Pharmaceuticals Director Joseph H. Wender Reports Sale of Common Shares

Ionis Pharmaceuticals Amends 8-K to Add Advisory Agreement with Richard Geary

Earnings Update: Here's Why Analysts Just Lifted Their Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Price Target To US$81.91

Simply Wall St.

Ionis Pharmaceuticals Faces Investor Risks Amid Market Volatility and Milestone Uncertainties

Ionis Pharmaceuticals, Inc. : H.c. Wainwright Raises Target Price to $100 From $95

THOMSON REUTERS

Ionis Pharmaceuticals Inc : Bernstein Raises Target Price to $65 From $50

THOMSON REUTERS

Ionis Pharmaceuticals Is Maintained at Buy by Needham

Ionis Pharmaceuticals: Strong Q3 Performance and Promising Pipeline Drive Buy Rating

Ionis Pharmaceuticals Inc : Barclays Raises Target Price to $95 From $80

THOMSON REUTERS

Ionis Pharmaceuticals Inc : TD Cowen Raises Target Price to $99 From $59

THOMSON REUTERS

Ionis Pharmaceuticals Inc : Leerink Partners Raises Target Price to $72.00 From $68.00

THOMSON REUTERS

Ionis Pharmaceuticals Shines in Q3 2025 Earnings Call

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Ionis Pharmaceuticals Inc. published the original content used to generate this news brief on November 08, 2025, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251108:nNDL2RNGRb:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2582886685","title":"Analysts Offer Insights on Healthcare Companies: Ionis Pharmaceuticals (IONS) and Immunocore Holdings (IMCR)","url":"https://stock-news.laohu8.com/highlight/detail?id=2582886685","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2582886685?lang=en_us&edition=fundamental","pubTime":"2025-11-09 00:50","pubTimestamp":1762620615,"startTime":"0","endTime":"0","summary":"There’s a lot to be optimistic about in the Healthcare sector as 2 analysts just weighed in on Ionis Pharmaceuticals (IONS – Research Report) and I...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-ionis-pharmaceuticals-ions-and-immunocore-holdings-imcr-blurbs?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-ionis-pharmaceuticals-ions-and-immunocore-holdings-imcr-blurbs?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS","BK4588","LU0128526141.USD","BK4137","IMCR","HCSG","BK4139","BK4585","LU0029874061.USD","XBI","XLV","BK4505","LABU","BK4581"],"gpt_icon":0},{"id":"2581186318","title":"Olezarsen Achieves Up to 72% Triglyceride Reduction in Phase 3 sHTG Trials","url":"https://stock-news.laohu8.com/highlight/detail?id=2581186318","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581186318?lang=en_us&edition=fundamental","pubTime":"2025-11-08 22:52","pubTimestamp":1762613558,"startTime":"0","endTime":"0","summary":"Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Swedish Orphan Biovitrum AB published the original content used to generate this news brief on November 08, 2025, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251108:nNDLbTTGs1:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2581832855","title":"Ionis Pharmaceuticals EVP Brian Birchler Reports Sale of Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2581832855","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581832855?lang=en_us&edition=fundamental","pubTime":"2025-11-08 06:13","pubTimestamp":1762553626,"startTime":"0","endTime":"0","summary":"Brian Birchler, EVP, Corporate and Development Operations at Ionis Pharmaceuticals Inc., reported a disposal of common shares of the company. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on November 07, 2025, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251107:nNDL1F6bdj:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Ionis Pharmaceuticals EVP Brian Birchler Reports Sale of Common Shares","news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2581722932","title":"William Blair Reaffirms Their Buy Rating on Ionis Pharmaceuticals (IONS)","url":"https://stock-news.laohu8.com/highlight/detail?id=2581722932","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581722932?lang=en_us&edition=fundamental","pubTime":"2025-11-05 20:36","pubTimestamp":1762346194,"startTime":"0","endTime":"0","summary":"William Blair analyst Myles Minter maintained a Buy rating on Ionis Pharmaceuticals yesterday. The company’s shares closed yesterday at $72.88. Min...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/william-blair-reaffirms-their-buy-rating-on-ionis-pharmaceuticals-ions-blurbs?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/william-blair-reaffirms-their-buy-rating-on-ionis-pharmaceuticals-ions-blurbs?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS"],"gpt_icon":0},{"id":"2581512517","title":"Ionis Pharmaceuticals Is Maintained at Overweight by Piper Sandler","url":"https://stock-news.laohu8.com/highlight/detail?id=2581512517","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2581512517?lang=en_us&edition=fundamental","pubTime":"2025-11-05 00:44","pubTimestamp":1762274640,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  November 04, 2025 11:44 ET (16:44 GMT)","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"gpt_icon":0},{"id":"2580075192","title":"U.S. RESEARCH ROUNDUP-Affiliated Managers Group, Argenx, Cardinal Health","url":"https://stock-news.laohu8.com/highlight/detail?id=2580075192","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2580075192?lang=en_us&edition=fundamental","pubTime":"2025-11-04 15:49","pubTimestamp":1762242555,"startTime":"0","endTime":"0","summary":"U.S. RESEARCH ROUNDUP-Affiliated Managers Group, Argenx, Cardinal HealthNov 4 (Reuters) - Wall Street securities analysts revised their ratings and price targets on several U.S.-listed companies, incl","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251104:nL4N3WG0NT:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["HIG","THG","FOR","ACHC","FBIN","IE00BQXX3F31.USD","LU0757428866.USD","CNC","CI","CBT","INCY","BRO","IE00BVYPNQ40.USD","USAW.SI","IDXX","BCRX","BRKR","CINF","AVB","IONS","DNLI","LU0353189680.USD","CLX","ARES","BK4515","EXAS","INSP","CSTL","AMG","HLIT","IE00BJTD4N35.SGD","ARE","FLS","XOM","AMRC","LU2106854487.HKD","CZR","LU2237438978.USD","CAH","AXSM","LU1868836591.USD","LU1551013425.SGD","EMN","ARGX","EVER","MO","ARDX"],"gpt_icon":1},{"id":"2580273086","title":"Ionis Pharmaceuticals Director Joseph H. Wender Reports Sale of Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2580273086","media":"Reuters","labels":["shareholding","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2580273086?lang=en_us&edition=fundamental","pubTime":"2025-11-04 09:15","pubTimestamp":1762218931,"startTime":"0","endTime":"0","summary":"Joseph H. Wender, Director, reported a disposal of common shares of Ionis Pharmaceuticals Inc. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on November 03, 2025, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251104:nNDL7Kl3y4:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2580297352","title":"Ionis Pharmaceuticals Amends 8-K to Add Advisory Agreement with Richard Geary","url":"https://stock-news.laohu8.com/highlight/detail?id=2580297352","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2580297352?lang=en_us&edition=fundamental","pubTime":"2025-11-04 06:18","pubTimestamp":1762208325,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals Inc. has issued an amendment to its previously filed Form 8-K from June 12, 2025, to include a new Item 1.01 and attach Richard Geary's Advisory Services Agreement as an exhibit.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on November 03, 2025, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251103:nNDL3R3sKT:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2580847888","title":"Earnings Update: Here's Why Analysts Just Lifted Their Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Price Target To US$81.91","url":"https://stock-news.laohu8.com/highlight/detail?id=2580847888","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2580847888?lang=en_us&edition=fundamental","pubTime":"2025-11-01 21:03","pubTimestamp":1762002225,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals, Inc. ( NASDAQ:IONS ) defied analyst predictions to release its third-quarter results, which were...","market":"hk","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/earnings-update-heres-why-analysts-just-lifted-their-ionis-p","rn_cache_url":null,"directOrigin":true},"property":["rate","earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/earnings-update-heres-why-analysts-just-lifted-their-ionis-p","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":[".IXIC","IONS"],"gpt_icon":0},{"id":"2579439871","title":"Ionis Pharmaceuticals Faces Investor Risks Amid Market Volatility and Milestone Uncertainties","url":"https://stock-news.laohu8.com/highlight/detail?id=2579439871","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2579439871?lang=en_us&edition=fundamental","pubTime":"2025-10-31 14:01","pubTimestamp":1761890486,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals Inc. (IONS) has disclosed a new risk, in the Debt & Financing category. Ionis Pharmaceuticals Inc. faces significant risks re...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-faces-investor-risks-amid-market-volatility-and-milestone-uncertainties?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-faces-investor-risks-amid-market-volatility-and-milestone-uncertainties?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2579350147","title":"Ionis Pharmaceuticals, Inc. : H.c. 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