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Bill Sibold; Chief Executive Officer; Madrigal Pharmaceuticals Inc. Mardi Dier; Chief Financial Officer, Senior Vice President; Madrigal Pharmaceuticals Inc. Michael Charlton; Senior Vice President, Clinical Development; Madrigal Pharmaceuticals. Good day, and thank you for standing by. Welcome to Madrigal Pharmaceuticals Fourth Quarter 2024 Earnings Conference Call.  As a reminder, today's conference call is being recorded.I'd like to introduce Ms. Tina Ventura, Chief Investor Relations Officer. Please go ahead.Well, thanks, Tina. Good morning and thanks for joining. Today I'll provide an update on the significant momentum we're building with the US launch of Rezdiffra. We ended 2024 strong and we're pleased with how we've started the year in 2025.I'll also share an update on new two-year data from an open label study for F4C patients as Tina mentioned. The results are very promising and support Rezdiffra's ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/q4-2024-madrigal-pharmaceuticals-inc-044312412.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["MDGL"],"gpt_icon":0},{"id":"2514862633","title":"JMP Securities Reaffirms Their Buy Rating on Madrigal Pharmaceuticals (MDGL)","url":"https://stock-news.laohu8.com/highlight/detail?id=2514862633","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514862633?lang=en_us&edition=fundamental","pubTime":"2025-02-27 04:15","pubTimestamp":1740600919,"startTime":"0","endTime":"0","summary":"JMP Securities analyst Jonathan Wolleben reiterated a Buy rating on Madrigal Pharmaceuticals (MDGL – Research Report) today and set a price target ...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/jmp-securities-reaffirms-their-buy-rating-on-madrigal-pharmaceuticals-mdgl-6?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/jmp-securities-reaffirms-their-buy-rating-on-madrigal-pharmaceuticals-mdgl-6?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["JMP","MDGL"],"gpt_icon":0},{"id":"2514102863","title":"Madrigal Pharmaceuticals Shares Jump After Q4 Beat, Release of New Data on Steatohepatitis Drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2514102863","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514102863?lang=en_us&edition=fundamental","pubTime":"2025-02-27 01:25","pubTimestamp":1740590701,"startTime":"0","endTime":"0","summary":"Madrigal Pharmaceuticals  shares advanced nearly 21% in recent Wednesday trading after the company released results for Q4 and new data on its Rezdiffra drug.The company reported a Q4 net loss of $2.71 per diluted share on revenue of $103.3 million, topping market expectations.The company also said patients with metabolic dysfunction-associated steatohepatitis treated with its Rezdiffra drug showed \"marked reductions\" in liver stiffness.Price: 373.33, Change: +63.84, Percent Change: +20.63","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4585","BK4139","MDGL","BK4588"],"gpt_icon":0},{"id":"2514869238","title":"Madrigal Q4 Earnings Beat, MASH Drug Sales Drive Top Line, Stock Up","url":"https://stock-news.laohu8.com/highlight/detail?id=2514869238","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514869238?lang=en_us&edition=fundamental","pubTime":"2025-02-27 00:53","pubTimestamp":1740588780,"startTime":"0","endTime":"0","summary":"Find the latest EPS estimates and surprises on Zacks Earnings Calendar.During the quarter, the company generated total revenues of $103.3 million entirely from product sales of itsmetabolic dysfunction-associated steatohepatitis  drug Rezdiffra , which was approved last year. The metric beat the Zacks Consensus Estimate of $101.6 million. Since this is also the first marketed drug in Madrigal’s portfolio, launched in April 2024, management did not generate any sales in the year-ago period.MDGL shares are gaining in the premarket hour, in response to the better-than-expected earnings results.During the quarter, research and development expenses declined 64% to $25.6 million. The decrease can be attributed to reduced clinical study costs and change in accounting for inventory costs following FDA approval of Rezdiffra, partially offset by increases in headcount.As the FDA approved Rezdiffra under the accelerated pathway, the continued approval will be based on promising long-term safety a","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/madrigal-q4-earnings-beat-mash-165300207.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["MDGL"],"gpt_icon":0},{"id":"2514427857","title":"Madrigal Pharmaceuticals Phase 3 data ‘encouraging,’ says UBS","url":"https://stock-news.laohu8.com/highlight/detail?id=2514427857","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514427857?lang=en_us&edition=fundamental","pubTime":"2025-02-27 00:05","pubTimestamp":1740585926,"startTime":"0","endTime":"0","summary":"Madrigal Pharmaceuticals (MDGL) reported Q4 results and provided a 2-year update from the open-label metabolic dysfunction-associated steatohepatit...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/madrigal-pharmaceuticals-phase-3-data-encouraging-says-ubs?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/madrigal-pharmaceuticals-phase-3-data-encouraging-says-ubs?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","BK4585","MDGL","BK4588"],"gpt_icon":0},{"id":"2514854477","title":"BUZZ-Madrigal rises on robust sales and long-term data for liver disease drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2514854477","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514854477?lang=en_us&edition=fundamental","pubTime":"2025-02-26 23:38","pubTimestamp":1740584296,"startTime":"0","endTime":"0","summary":"BUZZ-Madrigal rises on robust sales and long-term data for liver disease drug** Shares of drugmaker Madrigal Pharmaceuticals MDGL.O  rise 13.8% to $352.3** Co reports Q4 sales of $103.3 mln from its f","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250226:nL3N3PH1G7:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["MDGL"],"gpt_icon":0},{"id":"2514790857","title":"Why Madrigal Pharmaceuticals Stock Is Soaring Today","url":"https://stock-news.laohu8.com/highlight/detail?id=2514790857","media":"Motley Fool","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514790857?lang=en_us&edition=fundamental","pubTime":"2025-02-26 23:27","pubTimestamp":1740583620,"startTime":"0","endTime":"0","summary":"The company also announced positive new two-year data from a phase 3 study of its MASH drug Rezdiffra.Small biotech stocks usually aren't a great fit for risk-averse investors. However, I think aggressive growth investors might want to consider buying Madrigal Pharmaceuticals' shares.Some analysts project that Rezdiffra could generate peak annual sales of close to $3.5 billion. With Madrigal's market cap hovering around $7.7 billion, the stock should have more room to run.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.fool.com/investing/2025/02/26/why-madrigal-pharmaceuticals-stock-is-soaring-toda/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":"fool_stock","symbols":["MDGL","BK4585","BK4588","BK4139"],"gpt_icon":0},{"id":"1112394305","title":"Stock Track | Madrigal Pharmaceuticals Soars 8.24% in Pre-market on Promising Rezdiffra Data and Better-Than-Expected Q4 Results","url":"https://stock-news.laohu8.com/highlight/detail?id=1112394305","media":"Stock Track","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1112394305?lang=en_us&edition=fundamental","pubTime":"2025-02-26 22:44","pubTimestamp":1740581069,"startTime":"0","endTime":"0","summary":"Shares of Madrigal Pharmaceuticals  surged 8.24% in the pre-market trading session on Wednesday, February 26, 2025, driven by the company's promising clinical trial data for its drug Rezdiffra and better-than-expected financial results for the fourth quarter of 2024.Madrigal reported positive two-year data from the open-label compensated MASH  cirrhosis arm of the Phase 3 MAESTRO-NAFLD-1 trial. Patients treated with Rezdiffra achieved a mean 6.7 kPa reduction in liver stiffness, the largest repo","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":"ai_movement_en","symbols":["MDGL"],"gpt_icon":0},{"id":"2514771855","title":"Madrigal Pharmaceuticals Shares up 11.9% After Q4 Sales of Co's Fatty Liver Disease Drug Beat Estimates","url":"https://stock-news.laohu8.com/highlight/detail?id=2514771855","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514771855?lang=en_us&edition=fundamental","pubTime":"2025-02-26 22:38","pubTimestamp":1740580687,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250226:nFWN3PH1JY:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4588","BK4585","BK4139","MDGL"],"gpt_icon":0},{"id":"2514856818","title":"Madrigal Pharmaceuticals Says Steatohepatitis Drug Shows 'Marked Reductions' in Patients' Liver Stiffness","url":"https://stock-news.laohu8.com/highlight/detail?id=2514856818","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514856818?lang=en_us&edition=fundamental","pubTime":"2025-02-26 22:37","pubTimestamp":1740580630,"startTime":"0","endTime":"0","summary":"Madrigal Pharmaceuticals  said Wednesday that patients with metabolic dysfunction-associated steatohepatitis treated with its Rezdiffra drug showed \"marked reductions\" in liver stiffness.After two years of treatment with the drug, the vibration-controlled transient elastography results of 101 patients showed a statistically significant reduction in liver stiffness, the company said.The late-stage trial of Rezdiffra included an open-label active treatment arm for patients with compensated MASH cirrhosis.The company said 51% of the patients achieved a 25% or greater reduction in liver stiffness, which has been linked to a reduced progression to end-stage liver disease.Madrigal said it plans to present additional trial results from the compensated MASH cirrhosis arm at a future medical conference.","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["MDGL","BK4585","BK4588","BK4139"],"gpt_icon":0},{"id":"2514855422","title":"Madrigal Pharmaceuticals Inc reports results for the quarter ended December 31 - Earnings Summary","url":"https://stock-news.laohu8.com/highlight/detail?id=2514855422","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514855422?lang=en_us&edition=fundamental","pubTime":"2025-02-26 22:31","pubTimestamp":1740580317,"startTime":"0","endTime":"0","summary":"Madrigal Pharmaceuticals Inc reports results for the quarter ended December 31 - Earnings SummaryMadrigal Pharmaceuticals Inc MDGL.OQ reported a quarterly adjusted loss of $2.71 per share for the quar","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250226:nL5N3PH1UL:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["MDGL"],"gpt_icon":0},{"id":"2514268853","title":"Sector Update: Health Care Stocks Decline Pre-Bell Wednesday","url":"https://stock-news.laohu8.com/highlight/detail?id=2514268853","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514268853?lang=en_us&edition=fundamental","pubTime":"2025-02-26 22:14","pubTimestamp":1740579253,"startTime":"0","endTime":"0","summary":"Health care stocks were declining pre-bell Wednesday, with the iShares Biotechnology ETF (IBB) 0.3% lower and The Health Care Select Sector SPDR Fund (XLV) down 0.2%.United Therapeutics (UTHR) shares ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4585","OPCH","XLV","LU2065731478.USD","BK4532","BK4196","MDGL","BK4588","IBB","LU1571399168.USD","UTHR","LU1699723380.USD","BK4581","BK4139"],"gpt_icon":0},{"id":"1168052020","title":"Stock Track | Madrigal Pharmaceuticals Soars 6.63% Pre-Market on Positive Q4 Results and Promising Rezdiffra Data","url":"https://stock-news.laohu8.com/highlight/detail?id=1168052020","media":"Stock Track","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1168052020?lang=en_us&edition=fundamental","pubTime":"2025-02-26 21:53","pubTimestamp":1740578014,"startTime":"0","endTime":"0","summary":"Madrigal Pharmaceuticals  stock surged 6.63% in the pre-market trading session on Wednesday, February 26, 2025, driven by the company's better-than-expected financial results and promising clinical trial data for its drug Rezdiffra.The biopharmaceutical company reported fourth-quarter 2024 revenue of $103.3 million, exceeding analyst estimates of $99.1 million, and a narrower net loss of $2.71 per share compared to the expected loss of $4.12 per share. Madrigal ended the year with a strong cash ","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":"ai_movement_en","symbols":["MDGL"],"gpt_icon":0},{"id":"2514851093","title":"Madrigal (MDGL) Reports Q4 Loss, Tops Revenue Estimates","url":"https://stock-news.laohu8.com/highlight/detail?id=2514851093","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514851093?lang=en_us&edition=fundamental","pubTime":"2025-02-26 21:25","pubTimestamp":1740576311,"startTime":"0","endTime":"0","summary":"Madrigal  came out with a quarterly loss of $2.71 per share versus the Zacks Consensus Estimate of a loss of $4.12. This compares to loss of $5.68 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of 34.22%. A quarter ago, it was expected that this biopharmaceutical company would post a loss of $6.94 per share when it actually produced a loss of $4.92, delivering a surprise of 29.11%.Over the last four quarters, the company has surpassed consensus EPS estimates three times.Madrigal , which belongs to the Zacks Medical - Drugs industry, posted revenues of $103.32 million for the quarter ended December 2024, surpassing the Zacks Consensus Estimate by 1.69%. This compares to zero revenues a year ago.Madrigal shares have added about 0.3% since the beginning of the year versus the S&P 500's gain of 1.3%.While Madrigal has underperformed the market so far this year, the question that comes to investors' minds is: wh","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/madrigal-mdgl-reports-q4-loss-132511150.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["MDWD","MDGL"],"gpt_icon":0},{"id":"2514535832","title":"BRIEF-Madrigal Announces Two-Year Data From The Compensated Mash Cirrhosis Arm Of The Maestro-Nafld-1 Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2514535832","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514535832?lang=en_us&edition=fundamental","pubTime":"2025-02-26 20:52","pubTimestamp":1740574369,"startTime":"0","endTime":"0","summary":"BRIEF-Madrigal Announces Two-Year Data From The Compensated Mash Cirrhosis Arm Of The Maestro-Nafld-1 Trial Feb 26 (Reuters) - Madrigal Pharmaceuticals Inc MDGL.O:MADRIGAL ANNOUNCES NEW TWO-YEAR DATA ","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250226:nTUA1NQYLX:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","BK4585","BK4588","MDGL"],"gpt_icon":0},{"id":"2514831488","title":"Madrigal Pharmaceuticals' Q4 Net Loss Narrows, Revenue Tops Estimates","url":"https://stock-news.laohu8.com/highlight/detail?id=2514831488","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514831488?lang=en_us&edition=fundamental","pubTime":"2025-02-26 20:25","pubTimestamp":1740572751,"startTime":"0","endTime":"0","summary":"Madrigal Pharmaceuticals  reported a Q4 net loss Wednesday of $2.71 per diluted share, narrowing from a loss of $5.68 a year earlier.Analysts polled by FactSet expected EPS loss of $3.92.Revenue for the quarter ended Dec. 31 was $103.3 million. Analysts surveyed by FactSet expected $99.1 million.As of Dec. 31, the company said it had $931.3 million in cash and or cash equivalents on hand, compared with $634.1 million a year earlier.The company shares were up almost 5% in recent premarket activity.","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["MDGL"],"gpt_icon":0}],"pageSize":16,"totalPage":10,"pageCount":2,"totalSize":159}]}}