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Dosed in Phase 1 Clinical Study of Pali-2108 for the Treatment of Moderate-to-Severe Ulcerative Colitis (Uc)","url":"https://stock-news.laohu8.com/highlight/detail?id=2481907844","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2481907844?lang=en_us&edition=fundamental","pubTime":"2024-11-07 21:30","pubTimestamp":1730986201,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20241107:nTUABPWJC6:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4007","PALI","BK4139"],"gpt_icon":0},{"id":"2481690034","title":"Palisade Bio Announces First Subject Dosed in Phase 1 Clinical Study of PALI-2108 for the Treatment of Moderate-to-Severe Ulcerative Colitis (UC)","url":"https://stock-news.laohu8.com/highlight/detail?id=2481690034","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2481690034?lang=en_us&edition=fundamental","pubTime":"2024-11-07 21:30","pubTimestamp":1730986200,"startTime":"0","endTime":"0","summary":"Carlsbad,CA, Nov.  07, 2024  (GLOBE NEWSWIRE) -- Palisade Bio, Inc.(Nasdaq: PALI) (“Palisade,” “Palisade Bio” or the “Company”), a biopharmaceutical company focused on developing and advancing novel 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Ulcerative Colitis","url":"https://stock-news.laohu8.com/highlight/detail?id=2479608902","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2479608902?lang=en_us&edition=fundamental","pubTime":"2024-10-31 20:30","pubTimestamp":1730377800,"startTime":"0","endTime":"0","summary":"Targeted, better-tolerated oral PDE4 inhibitors are an unmet need in inflammatory bowel disease . PALI-2108 demonstrates in ex vivo studies; targeted activation and reduced side effects, potentially enhancing patient compliance compared to existing PDE4 inhibitors. The poster titled “Colonic Bioactivation and Potent TNFα Inhibition of PALI-2108 in Human Clinical Studies: A Promising PDE4 Inhibitor Prodrug for the Oral Treatment of Ulcerative Colitis,” was presented by Dr. Mitch Jones, Chief Medical Officer of Palisade Bio, at the ACG 2024 Annual Scientific Meeting, held October 25-30, 2024, in Philadelphia, PA.“The design of PALI-2108 ensures that activation is targeted primarily in the colon, which should minimize systemic exposure and potential central nervous system side effects. By demonstrating reduced systemic exposure, we believe PALI-2108 can effectively address the toxicity issues commonly associated with other PDE4 inhibitors like roflumilast and apremilast,” stated Dr. Mitch","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/9pRvRuURDlO1_YMCjSwOsw--~B/aD0xMTk7dz00NjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/globenewswire.com/4986e16c7ba951018cc07b5956db4a27","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/9pRvRuURDlO1_YMCjSwOsw--~B/aD0xMTk7dz00NjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/globenewswire.com/4986e16c7ba951018cc07b5956db4a27"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/palisade-bio-announces-positive-data-123000631.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4007","BK4139","PALI","IBD"],"gpt_icon":0},{"id":"2479733236","title":"Palisade Bio Files for Public Offering of Shares, Warrants","url":"https://stock-news.laohu8.com/highlight/detail?id=2479733236","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2479733236?lang=en_us&edition=fundamental","pubTime":"2024-10-30 23:33","pubTimestamp":1730302404,"startTime":"0","endTime":"0","summary":"Palisade Bio  on Wednesday filed a registration statement with the US Securities and Exchange Commission for a public offering of shares or pre-funded warrants.The actual size and pricing of the offering are yet to be determined.Pre-funded warrants will be offered to shareholders owning more than a 4.99% stake in the company after buying common shares under the offering. Each pre-funded warrant allows for one common share upon exercise, the company said.Palisade shares fell 8% in recent trading.Price: 3.11, Change: -0.27, Percent Change: -8.02","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4139","BK4007","PALI"],"gpt_icon":1},{"id":"2474820742","title":"Palisade Bio Gets Health Canada Clearance to Start Phase 1 Study of PALI-2108 for Treating Ulcerative Colitis","url":"https://stock-news.laohu8.com/highlight/detail?id=2474820742","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2474820742?lang=en_us&edition=fundamental","pubTime":"2024-10-10 22:29","pubTimestamp":1728570549,"startTime":"0","endTime":"0","summary":"Palisade Bio (PALI) said Thursday it has received clearance from Health Canada to start a phase 1 trial that will evaluate PALI-2108 for the treatment of ulcerative colitis.Preparations for the trial ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4139","BK4007","PALI"],"gpt_icon":0},{"id":"2474371004","title":"BRIEF-Palisade Bio Cleared By Health Canada To Commence Phase 1 Clinical Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2474371004","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2474371004?lang=en_us&edition=fundamental","pubTime":"2024-10-10 20:45","pubTimestamp":1728564322,"startTime":"0","endTime":"0","summary":"Oct 10  - Palisade Bio Inc   :   * PALISADE BIO CLEARED BY HEALTH CANADA TO COMMENCE PHASE 1 CLINICAL STUDY FOR LEAD PROGRAM, PALI-2108 FOR THE TREATMENT OF ULCERATIVE COLITIS    * PALISADE BIO INC - ON TRACK COMMENCE SITE INITIATION AND ENROLLMENT FOR STUDY BEFORE YEAR ENDSource text for Eikon:    Further company coverage:    ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.rkd.refinitiv.com/api/News/News.svc/REST/News_1/RetrieveStoryML_1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","BK4007","PALI"],"gpt_icon":0},{"id":"2474971771","title":"Palisade Bio Inc - on Track Commence Site Initiation and Enrollment for Study Before Year End","url":"https://stock-news.laohu8.com/highlight/detail?id=2474971771","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2474971771?lang=en_us&edition=fundamental","pubTime":"2024-10-10 20:31","pubTimestamp":1728563504,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20241010:nFWN3LM10N:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4007","BK4139","PALI"],"gpt_icon":0},{"id":"2474717792","title":"Palisade Bio Cleared by Health Canada to Commence Phase 1 Clinical Study for Lead Program, Pali-2108 for the Treatment of Ulcerative Colitis (Uc)","url":"https://stock-news.laohu8.com/highlight/detail?id=2474717792","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2474717792?lang=en_us&edition=fundamental","pubTime":"2024-10-10 20:31","pubTimestamp":1728563504,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20241010:nFWN3LM10N:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","PALI","BK4007"],"gpt_icon":0},{"id":"2474710805","title":"Palisade Bio Cleared by Health Canada to Commence Phase 1 Clinical Study for Lead Program, PALI-2108 for the Treatment of Ulcerative Colitis (UC)","url":"https://stock-news.laohu8.com/highlight/detail?id=2474710805","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2474710805?lang=en_us&edition=fundamental","pubTime":"2024-10-10 20:30","pubTimestamp":1728563400,"startTime":"0","endTime":"0","summary":"– Company has received a No Objection Letter from Health Canada in response to submission of its Phase 1 Clinical Trial Application . – The study is a Phase 1 Single Ascending Dose  /Multiple Ascending Dose  and food effects  and includes multiple dose treatment of UC patients; Global UC market is expected to grow to nearly $10 Billion by 2028. Carlsbad,CA, Oct. 10, 2024  -- Palisade Bio, Inc. , a biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today announced that it has received a No Objection Letter from Health Canada for its Phase 1 human clinical study for PALI-2108 for the treatment of UC.The primary objective of the study will be to assess the safety and tolerability of single  and repeated  oral doses of PALI-2108. Secondary objectives include determining the plasma, urinary, and fecal (MAD healthy subjects and UC patie","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/9pRvRuURDlO1_YMCjSwOsw--~B/aD0xMTk7dz00NjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/globenewswire.com/4986e16c7ba951018cc07b5956db4a27","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/9pRvRuURDlO1_YMCjSwOsw--~B/aD0xMTk7dz00NjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/globenewswire.com/4986e16c7ba951018cc07b5956db4a27"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/palisade-bio-cleared-health-canada-123000269.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4198","BK4023","PD","LU1804176565.USD","BK4081","BK4181","BK4588","LU1169589451.USD","BK4218","ALC","BK4585","BK4139","BK4534","BK4007","LU2265009873.SGD","PALI","LU1169590202.USD","FE","CTA","PK"],"gpt_icon":0},{"id":"2470256367","title":"BRIEF-Palisade Bio Provides Update On Progress Toward Launch Of Phase 1 Human Clinical Study For Lead Program, Pali-2108 For The Treatment Of Ulcerative Colitis","url":"https://stock-news.laohu8.com/highlight/detail?id=2470256367","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2470256367?lang=en_us&edition=fundamental","pubTime":"2024-09-25 20:03","pubTimestamp":1727265819,"startTime":"0","endTime":"0","summary":"Sept 25  - Palisade Bio Inc   :   * PALISADE BIO PROVIDES UPDATE ON PROGRESS TOWARD LAUNCH OF PHASE 1 HUMAN CLINICAL STUDY FOR LEAD PROGRAM, PALI-2108 FOR THE TREATMENT OF ULCERATIVE COLITIS   * PALISADE BIO:  ON TRACK TOWARDS CLINICAL SITE INITIATION AND DOSING OF FIRST PATIENT IN PHASE 1 HUMAN CLINICAL STUDY BEFORE YEAR ENDSource text for Eikon:    Further company coverage:    ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.rkd.refinitiv.com/api/News/News.svc/REST/News_1/RetrieveStoryML_1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PRGS","PALI","BK4139","BK4097","LU2065732104.USD","BK4007"],"gpt_icon":1},{"id":"2470550522","title":"Palisade Bio:  on Track Towards Clinical Site Initiation and Dosing of First Patient in Phase 1 Human Clinical Study Before Year End","url":"https://stock-news.laohu8.com/highlight/detail?id=2470550522","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2470550522?lang=en_us&edition=fundamental","pubTime":"2024-09-25 20:00","pubTimestamp":1727265601,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20240925:nTUA6FDKNZ:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","BK4007","PALI"],"gpt_icon":0},{"id":"2470255420","title":"Palisade Bio Provides Update on Progress Toward Launch of Phase 1 Human Clinical Study for Lead Program, Pali-2108 for the Treatment of Ulcerative Colitis","url":"https://stock-news.laohu8.com/highlight/detail?id=2470255420","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2470255420?lang=en_us&edition=fundamental","pubTime":"2024-09-25 20:00","pubTimestamp":1727265601,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20240925:nTUA6FDKNZ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["PALI","BK4007","BK4139"],"gpt_icon":0},{"id":"2470550532","title":"Palisade Bio Provides Update on Progress Toward Launch of Phase 1 Human Clinical Study for Lead Program, PALI-2108 for the Treatment of Ulcerative Colitis","url":"https://stock-news.laohu8.com/highlight/detail?id=2470550532","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2470550532?lang=en_us&edition=fundamental","pubTime":"2024-09-25 20:00","pubTimestamp":1727265600,"startTime":"0","endTime":"0","summary":"– Completion of nonclinical safety and toxicity studies, Phase 1 clinical trial design and established Maximum Recommended Starting Dose. – Completion of pre- Clinical Trial Application  meeting with Health Canada. – Submission of the CTA for the Phase 1 clinical study of Normal Healthy Volunteers and ulcerative colitis patients. – On track towards clinical site initiation and dosing of first patient in Phase 1 human clinical study before year end. The Company has submitted a CTA for its Phase 1 study of PALI-2108, which will be a single-center, double-blind, placebo-controlled study focused on safety, tolerability, pharmacokinetics, and p","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/9pRvRuURDlO1_YMCjSwOsw--~B/aD0xMTk7dz00NjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/globenewswire.com/4986e16c7ba951018cc07b5956db4a27","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/9pRvRuURDlO1_YMCjSwOsw--~B/aD0xMTk7dz00NjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/globenewswire.com/4986e16c7ba951018cc07b5956db4a27"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/palisade-bio-provides-progress-toward-120000527.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4181","BK4218","PALI","LU2065732104.USD","BK4007","BK4139","CTA","PRGS","BK4097","PK"],"gpt_icon":0},{"id":"2467814003","title":"Palisade Bio - Launches New Corporate Branding and Reiterates Commitment to Advancing Next-Generation Precision Therapies","url":"https://stock-news.laohu8.com/highlight/detail?id=2467814003","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2467814003?lang=en_us&edition=fundamental","pubTime":"2024-09-16 20:16","pubTimestamp":1726489000,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20240916:nFWN3KY105:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4007","PALI","BK4139"],"gpt_icon":0}],"pageSize":16,"totalPage":3,"pageCount":3,"totalSize":47}]}}