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All three doses met the primary endpoint of clinical response at Week 12, with a favorable safety profile. These results in ulcerative colitis build on strong data recently reported for the plaque psoriasis Phase 3 program. NEWARK, CALIFORNIA / ACCESS Newswire / March 10, 2025 / Protagonist Therapeutics, Inc.  today announced positive topline results from ANTHEM-UC, a Phase 2b study of icotrokinra , the first investigational targeted oral peptide that selectively blocks the IL-23 receptor, in adults with moderately to severely active ulcerative colitis . The study conducted by Protagonist's collaboration partner, Johnson & Johnson, met its primary endpoint of clinical responsea in all icotrokinra dose groups evaluated. Additionally, the study demonstrated clinically meaningful differences versus placebo in key secondary endpoints of","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/protagonist-reports-positive-top-line-121500609.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU1023059063.AUD","LU0345770993.USD","LU1261432733.SGD","LU0345769631.USD","LU0122379950.USD","IE00BJJMRZ35.SGD","IE00BJT1NW94.SGD","LU1674673691.USD","LU1894683264.USD","LU1066051811.HKD","LU1059921491.USD","BK4139","IE0009355771.USD","LU2129689514.USD","LU2592432038.USD","IE00BVYPNV92.GBP","LU0114720955.EUR","BK4581","LU1244550494.USD","PTGX","BK4588","LU0795875169.SGD","LU1066051498.USD","LU0320765646.SGD","IE00B19Z3581.USD","JNJ","LU0466842654.USD","IE00B4R5TH58.HKD","LU0289739699.SGD","IE0002270589.USD","IE000M9KFDE8.USD","LU0058720904.USD","LU0345769128.USD","LU0203347892.USD","LU1244550221.USD","LU2602419157.SGD","BK4504","LU1057294990.SGD","LU1914381329.SGD","LU1032466523.USD","BK4585","BK4007","BK4592","LU0889566641.SGD","LU1894683348.USD","LU2347655156.SGD","LU2129689431.USD","IE00B19Z3B42.SGD","IE00B42XCP33.USD","LU0203345920.USD"],"gpt_icon":0},{"id":"2518624799","title":"Protagonist Therapeutics Price Target Maintained With a $54.00/Share by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2518624799","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518624799?lang=en_us&edition=fundamental","pubTime":"2025-03-10 19:27","pubTimestamp":1741606020,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/PTGX/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  March 10, 2025 07:27 ET (11:27 GMT)","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PTGX"],"gpt_icon":0},{"id":"2518266971","title":"Protagonist Therapeutics: Buy Rating Backed by Promising Phase 3 Results and Market Potential of Icotrokinra","url":"https://stock-news.laohu8.com/highlight/detail?id=2518266971","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518266971?lang=en_us&edition=fundamental","pubTime":"2025-03-10 12:35","pubTimestamp":1741581334,"startTime":"0","endTime":"0","summary":"Jonathan Wolleben, an analyst from JMP Securities, reiterated the Buy rating on Protagonist Therapeutics (PTGX – Research Report). The associated p...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/ratings/protagonist-therapeutics-buy-rating-backed-by-promising-phase-3-results-and-market-potential-of-icotrokinra?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/ratings/protagonist-therapeutics-buy-rating-backed-by-promising-phase-3-results-and-market-potential-of-icotrokinra?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["PTGX"],"gpt_icon":0},{"id":"2518230558","title":"Analysts Offer Insights on Healthcare Companies: Protagonist Therapeutics (PTGX), Halozyme (HALO) and Arcturus Therapeutics (ARCT)","url":"https://stock-news.laohu8.com/highlight/detail?id=2518230558","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518230558?lang=en_us&edition=fundamental","pubTime":"2025-03-10 08:21","pubTimestamp":1741566079,"startTime":"0","endTime":"0","summary":"There’s a lot to be optimistic about in the Healthcare sector as 3 analysts just weighed in on Protagonist Therapeutics (PTGX – Research Report), H...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-protagonist-therapeutics-ptgx-halozyme-halo-and-arcturus-therapeutics-arct?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-protagonist-therapeutics-ptgx-halozyme-halo-and-arcturus-therapeutics-arct?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["ARCT","BK4139","LU0053671581.USD","HCSG","PTGX","HALO","BK4137"],"gpt_icon":0},{"id":"2516789326","title":"Protagonist Therapeutics Is Maintained at Overweight by JP Morgan","url":"https://stock-news.laohu8.com/highlight/detail?id=2516789326","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516789326?lang=en_us&edition=fundamental","pubTime":"2025-03-04 20:12","pubTimestamp":1741090320,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/PTGX/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  March 04, 2025 07:12 ET (12:12 GMT)","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PTGX"],"gpt_icon":0},{"id":"2516668204","title":"Protagonist Therapeutics: Positive VERIFY Trial Results and Promising Financial Prospects Justify Buy Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2516668204","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516668204?lang=en_us&edition=fundamental","pubTime":"2025-03-04 04:05","pubTimestamp":1741032326,"startTime":"0","endTime":"0","summary":"Protagonist Therapeutics (PTGX – Research Report), the Healthcare sector company, was revisited by a Wall Street analyst today. Analyst Julian Harr...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/ratings/protagonist-therapeutics-positive-verify-trial-results-and-promising-financial-prospects-justify-buy-rating?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/ratings/protagonist-therapeutics-positive-verify-trial-results-and-promising-financial-prospects-justify-buy-rating?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["PTGX"],"gpt_icon":0},{"id":"2516166827","title":"Protagonist Therapeutics price target raised to $73 from $67 at BTIG","url":"https://stock-news.laohu8.com/highlight/detail?id=2516166827","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516166827?lang=en_us&edition=fundamental","pubTime":"2025-03-04 04:00","pubTimestamp":1741032052,"startTime":"0","endTime":"0","summary":"BTIG raised the firm’s price target on Protagonist Therapeutics (PTGX) to $73 from $67 and keeps a Buy rating on the shares. Positive VERIFY data w...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/protagonist-therapeutics-price-target-raised-to-73-from-67-at-btig?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/protagonist-therapeutics-price-target-raised-to-73-from-67-at-btig?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["PTGX"],"gpt_icon":0},{"id":"2516654002","title":"News Flash: 10 Analysts Think Protagonist Therapeutics, Inc. (NASDAQ:PTGX) Earnings Are Under Threat","url":"https://stock-news.laohu8.com/highlight/detail?id=2516654002","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516654002?lang=en_us&edition=fundamental","pubTime":"2025-03-04 02:18","pubTimestamp":1741025929,"startTime":"0","endTime":"0","summary":"The latest analyst coverage could presage a bad day for Protagonist Therapeutics, Inc. , with the analysts making across-the-board cuts to their statutory estimates that might leave shareholders a little shell-shocked. Both revenue and earnings per share  forecasts went under the knife, suggesting the analysts have soured majorly on the business. At US$37.59, shares are up 4.4% in the past 7 days. Investors could be forgiven for changing their mind on the business following the downgrade; but it's not clear if the revised forecasts will lead to selling activity.Check out our latest analysis for Protagonist Therapeutics. Even so, the longer term trajectory of the business is much more important for the value creation of shareholders. We have estimates - from multiple Protagonist Therapeutics analysts -","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/news-flash-10-analysts-think-181849388.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":[".IXIC","NDAQ","PTGX"],"gpt_icon":0},{"id":"2516651557","title":"Protagonist Therapeutics Price Target Maintained With a $54.00/Share by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2516651557","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516651557?lang=en_us&edition=fundamental","pubTime":"2025-03-04 01:51","pubTimestamp":1741024260,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/PTGX/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  March 03, 2025 12:51 ET (17:51 GMT)","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PTGX"],"gpt_icon":0},{"id":"2516651448","title":"Protagonist Therapeutics’ Rusfertide: A Promising Blockbuster in the Polycythemia Vera Market with Strong Buy Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2516651448","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516651448?lang=en_us&edition=fundamental","pubTime":"2025-03-04 01:45","pubTimestamp":1741023923,"startTime":"0","endTime":"0","summary":"Protagonist Therapeutics (PTGX – Research Report), the Healthcare sector company, was revisited by a Wall Street analyst today. Analyst Douglas Tsa...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/ratings/protagonist-therapeutics-rusfertide-a-promising-blockbuster-in-the-polycythemia-vera-market-with-strong-buy-rating?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/ratings/protagonist-therapeutics-rusfertide-a-promising-blockbuster-in-the-polycythemia-vera-market-with-strong-buy-rating?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["PTGX"],"gpt_icon":0},{"id":"2516772656","title":"Takeda-Protagonist Therapeutics Partnered Investigational Drug Hits Primary Goal In Late-Stage Study In Patients With Type Of Blood Cancer","url":"https://stock-news.laohu8.com/highlight/detail?id=2516772656","media":"Benzinga","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516772656?lang=en_us&edition=fundamental","pubTime":"2025-03-04 01:01","pubTimestamp":1741021301,"startTime":"0","endTime":"0","summary":"On Monday, Protagonist Therapeutics, Inc.  and Takeda Pharmaceutical Co Ltd  released topline results for the Phase 3 VERIFY study of rusfertide for polycythemia vera.Polycythemia vera isa type of blood cancer. It causes your bone marrow to make too many red blood cells.Also Read: Neurocrine Obtains Exclusive Rights For Depression Drug, Takeda Reacquires Japan Rights. The study met its primary endpoint and all four key secondary endpoints. Rusfertide is a first-in-class investigational hepcidin mimetic peptide therapeutic, which has received FDA Orphan Drug and Fast Track designations.The study’s primary endpoint was the proportion of patients achieving a response, which was defined as the absence of phlebotomy eligibility.The first key secondary endpoint, which is the pre-specified primary endpoint for European Union  regulators, was also met, with a mean of 0.5 phlebotomies per patient in the rusfertide arm compared to 1.8 phlebotomies per patient in the placebo arm during weeks 0-32","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/takeda-protagonist-therapeutics-partnered-investigational-170141358.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["PTGX","BK4139","SSI","BK4156","TAK","BK4007"],"gpt_icon":0},{"id":"2516765581","title":"Protagonist Therapeutics Inc : JP Morgan Raises Target Price to $57 From $53","url":"https://stock-news.laohu8.com/highlight/detail?id=2516765581","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516765581?lang=en_us&edition=fundamental","pubTime":"2025-03-04 00:32","pubTimestamp":1741019554,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250303:nFWN3PM142:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["PTGX","BK4139"],"gpt_icon":0},{"id":"2516365847","title":"BUZZ-U.S. STOCKS ON THE MOVE-Melco Resorts, Chipotle, Allegro","url":"https://stock-news.laohu8.com/highlight/detail?id=2516365847","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516365847?lang=en_us&edition=fundamental","pubTime":"2025-03-03 23:59","pubTimestamp":1741017559,"startTime":"0","endTime":"0","summary":"BUZZ-U.S. STOCKS ON THE MOVE-Melco Resorts, Chipotle, AllegroEikon search string for individual stock moves: STXBZThe Day Ahead newsletter: https://refini.tv/3LI4BU7The Morning News Call newsletter: h","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250303:nL3N3PM158:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["00200","BK4112","CPRI","AVDL","ALGM","LU2756315318.SGD","LU1883866441.USD","ACON","LU2249611893.SGD","LU2471134879.HKD","GEL","LU0149725797.USD","LU1223082519.USD","LU0211331839.USD","MLCO","IE00BLSP4239.USD","FDX","LU0345780281.USD","ADT","STRK","IE00B3S45H60.SGD","NOVA","BHVN","CNH","PTGX","LU1244550577.SGD","FTRE","NEM","SGRY","LU0612318971.USD","AGCO","LU0672654240.SGD","BK4023","LU1778281490.HKD","CHKP","LU1261432733.SGD","LU0426417589.USD","SEDG","IE00BN8TJ469.HKD","LU1435385759.SGD","TSYW.SI","LUV","CMG"],"gpt_icon":1}],"pageSize":16,"totalPage":9,"pageCount":2,"totalSize":133}]}}