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Sage Therapeutics

7.43

+0.06000.81%

Post-market: 7.450.0200+0.27%17:08 EDT

Volume:616.54K

Turnover:4.59M

Market Cap:456.80M

PE:-1.13

High:7.54

Open:7.33

Low:7.33

Close:7.37

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Overview Company News Filings

Wedbush Cuts Price Target on SAGE Therapeutics to $4 From $7, Maintains Neutral Rating

MT Newswires Live

Sage Therapeutics Shares Down 3.7% After Stopping Development of Rare Disease Drug

THOMSON REUTERS

Sector Update: Health Care Stocks Edge Higher Premarket Wednesday

MT Newswires Live

Exchange-Traded Funds, Equity Futures Higher Pre-Bell as Traders Await Nvidia Earnings

MT Newswires Live

BUZZ-Sage Therapeutics declines after stopping development of rare disease drug

SAGE Therapeutics: Hold Rating Amid Strategic Shift Following Dalzanemdor Discontinuation

Sage Therapeutics to end Huntington's disease trial after key therapy fails again

Sage slips as Huntington’s Disease therapy fails in mid-stage trial

SAGE Therapeutics' Study of Dalzanemdor Fails to Meet Primary, Secondary Endpoints

MT Newswires Live

Sage Therapeutics Shares Slide Premarket After Dalzanemdor Fails Again

Sage Therapeutics Shares Down 18.5% Premarket After Co's Rare Disease Drug Fails to Meet Main Goal in Mid-Stage Study

THOMSON REUTERS

Sage Therapeutics' stock slides after trial of Huntington's Disease treatment fails and company says it will end it

Sage Therapeutics' rare disease drug fails mid-stage study

Sage Therapeutics reports results from Phase 2 DIMENSION Study

BRIEF-Sage Therapeutics Announces Topline Results from the Phase 2 DIMENSION Study of Dalzanemdor (SAGE-718)

Sage Therapeutics Inc - to Halt Further Development of Dalzanemdor

THOMSON REUTERS

Sage Therapeutics - to Close Ongoing Purview Study, an Open-Label Safety Study of Dalzanemdor in Participants With Hd

THOMSON REUTERS

Sage Therapeutics Inc - Dalzanemdor Did Not Meet Primary Endpoint in Phase 2 Study

THOMSON REUTERS

Sage Therapeutics Announces Topline Results From the Phase 2 Dimension Study of Dalzanemdor (Sage-718) in the Treatment of Cognitive Impairment Associated With Huntington’s Disease

THOMSON REUTERS

Sage Therapeutics Inc - Dalzanemdor Generally Well-Tolerated With No New Safety Signals

THOMSON REUTERS

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Cuts Price Target on SAGE Therapeutics to $4 From $7, Maintains Neutral Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2484148471","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484148471?lang=en_us&edition=fundamental","pubTime":"2024-11-20 23:03","pubTimestamp":1732115022,"startTime":"0","endTime":"0","summary":"SAGE Therapeutics (SAGE) has an average rating of hold and mean price target of $9.83, according to analysts polled by FactSet.Price: 4.76, Change: -0.15, Percent Change: 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22:18","pubTimestamp":1732112294,"startTime":"0","endTime":"0","summary":"Health care stocks were edging higher premarket Wednesday as the iShares Biotechnology ETF  was 0.4% higher and the Health Care Select Sector SPDR Fund  was recently up 0.5%.Argenx  shares were up more than 2% after the company said it will proceed with developing its experimental drug, efgartigimod subcutaneous, to treat idiopathic inflammatory myopathies in its ongoing phase 2/3 study.SAGE Therapeutics  shares were down over 5% after the company said its phase 2 DIMENSION study of dalzanemdor in participants with cognitive impairment associated with Huntington's Disease did not meet its primary and secondary endpoints.Novo Nordisk  has rolled out Wegovy in China to treat adults with obesity andoverweight, a company spokesperson confirmed to MT Newswires in an email. 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Ami Fadia’s rating is based on the...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/sage-therapeutics-hold-rating-amid-strategic-shift-following-dalzanemdor-discontinuation?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/sage-therapeutics-hold-rating-amid-strategic-shift-following-dalzanemdor-discontinuation?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SAGE"],"gpt_icon":0},{"id":"2484711885","title":"Sage Therapeutics to end Huntington's disease trial after key therapy fails again","url":"https://stock-news.laohu8.com/highlight/detail?id=2484711885","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484711885?lang=en_us&edition=fundamental","pubTime":"2024-11-20 20:35","pubTimestamp":1732106100,"startTime":"0","endTime":"0","summary":"Dalzanemdor has also failed as treatment for cognitive impairment in Alzheimer's disease and Parkinson's disease. Sage Therapeutics Inc.'s stock  fell 2% early Wednesday after the company said it would cease the development of a treatment for cognitive impairment associated with Huntington's disease after a failed trial.It was the third failed trial for the therapy, called dalzanemdor, which also failed to meet its goals in a Phase 2 trial as a treatment for mild cognitive impairment and mild dementia in Alzheimer's disease, as the company announced in October.In April, the company said dalzanemdor had failed to achieve statistically significant improvement in the treatment of mild cognitive impairment in Parkinson's disease.The latest Phase 2 trial sought to evaluate dalzanemdor as a therapy for Huntington's disease patients, but failed to show a statistically significant difference versus placebo at day 84. The trial also failed to meet secondary endpoints.\"We are disappointed by the","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4532","LU0109394709.USD","LU0234570918.USD","BK4585","BK4533","LU0320765992.SGD","IE00B19Z9P08.USD","BK4588","LU0889565916.HKD","SAGE","BIIB","BK4139","IE00B19Z9Z06.USD","IE00B894F039.SGD"],"gpt_icon":0},{"id":"2484919098","title":"Sage slips as Huntington’s Disease therapy fails in mid-stage trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2484919098","media":"seekingalpha","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484919098?lang=en_us&edition=fundamental","pubTime":"2024-11-20 20:20","pubTimestamp":1732105217,"startTime":"0","endTime":"0","summary":"koto_fejaShares of Sage Therapeutics  fell in the premarket on Wednesday after the company said dalzanemdor, its candidate for an inherited neurological condition called Huntington’s Disease, failed in a mid-stage trial. The 12-week DIMENSION study evaluated how dalzanemdor, also known as SAGE-718, will impact cognitive impairment found in 189 HD patients. Citing its topline data, the company said dalzanemdor didn’t lead to a statistically significant difference versus placebo on the Symbol Digit Modalities Test, a clinical measure used as the trial’s primary endpoint. Sage  said there were no statistically significant differences versus placebo for secondary endpoints either. Given the setback, the company will halt further R&D efforts related to dalzanemdor. As a result, SAGE’s ongoing PURVIEW safety trial, designed to test the candidate among HD patients, will also come to an end.","market":"sh","thumbnail":"https://static.seekingalpha.com/cdn/s3/uploads/getty_images/1798182222/image_1798182222.jpg?io=getty-c-w750","type":0,"news_type":0,"thumbnails":["https://static.seekingalpha.com/cdn/s3/uploads/getty_images/1798182222/image_1798182222.jpg?io=getty-c-w750"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://seekingalpha.com/news/4311044-sage-stock-slips-as-huntingtons-disease-trial-fails","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"seekingalpha_trending_news","symbols":[".IXIC","TQQQ","PSQ","SAGE","BK4139","QLD","MNQmain","NQmain","SQQQ","QID"],"gpt_icon":1},{"id":"2484920941","title":"SAGE Therapeutics' Study of Dalzanemdor Fails to Meet Primary, Secondary Endpoints","url":"https://stock-news.laohu8.com/highlight/detail?id=2484920941","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484920941?lang=en_us&edition=fundamental","pubTime":"2024-11-20 20:02","pubTimestamp":1732104150,"startTime":"0","endTime":"0","summary":"SAGE Therapeutics  said Wednesday that its phase 2 DIMENSION study of dalzanemdor in participants with cognitive impairment associated with Huntington's Disease did not meet its primary and secondary endpoints.The company said that the study was unable to demonstrate a statistically significant difference from baseline in participants treated with dalzanemdor versus placebo and as a result, it does not plan further development.Sage Therapeutics' share price fell more than 8% in recent premarket activity on Wednesday.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4139","SAGE"],"gpt_icon":0},{"id":"2484103192","title":"Sage Therapeutics Shares Slide Premarket After Dalzanemdor Fails Again","url":"https://stock-news.laohu8.com/highlight/detail?id=2484103192","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484103192?lang=en_us&edition=fundamental","pubTime":"2024-11-20 19:59","pubTimestamp":1732103940,"startTime":"0","endTime":"0","summary":"Sage Therapeutics shares tumbled in premarket trading Wednesday after the biopharmaceutical company threw in the towel on dalzanemdor following the drug candidate's latest study failure.Sage shares, which closed Tuesday at $4.91, were recently down 26% to $3.62 in premarket trading.The company on Wednesday said a Phase 2 study of dalzanemdor missed its goals in patients with cognitive impairment associated with the brain disorder Huntington's disease.Based on these results, the company does not plan further development of dalzanemdor.Sage earlier this year reported similar Phase 2 study failures of dalzanemdor in Alzheimer's and Parkinson's diseases, and the Cambridge, Mass., company last month slashed a third of its workforce.","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SAGE"],"gpt_icon":0},{"id":"2484194562","title":"Sage Therapeutics Shares Down 18.5% Premarket After Co's Rare Disease Drug Fails to Meet Main Goal in Mid-Stage Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2484194562","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484194562?lang=en_us&edition=fundamental","pubTime":"2024-11-20 19:44","pubTimestamp":1732103098,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20241120:nFWN3MR09R:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["SAGE","BK4139"],"gpt_icon":0},{"id":"2484194395","title":"Sage Therapeutics' stock slides after trial of Huntington's Disease treatment fails and company says it will end it","url":"https://stock-news.laohu8.com/highlight/detail?id=2484194395","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484194395?lang=en_us&edition=fundamental","pubTime":"2024-11-20 19:43","pubTimestamp":1732102980,"startTime":"0","endTime":"0","summary":"Sage Therapeutics Inc.'s stock  fell 18% early Wednesday, after the company said a mid-stage trial of a treatment for cognitive impairment associated with Huntington's Disease failed to meet its main goal. The Phase 2 trial sought to evaluate dalzanemdor as a therapy for that patient group but failed to show statistically significant difference versus placebo at day 84. The trial also failed to meet secondary endpoints and the company is not planning further development. \"We are disappointed by the results of the DIMENSION Study, especially for the individuals and families affected by Huntington's Disease who have long awaited new treatment options,\" Sage CEO Barry Greene said in prepared remarks. In October, Sage said it was cutting about 33% of its workforce as part of an overhaul of its business and pipeline that's expected to extend its cash runway. The stock has fallen 77% in the year to date, while the S&P 500  has gained 24%.This content was created by MarketWatch, which is oper","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SAGE"],"gpt_icon":0},{"id":"2484319176","title":"Sage Therapeutics' rare disease drug fails mid-stage study","url":"https://stock-news.laohu8.com/highlight/detail?id=2484319176","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484319176?lang=en_us&edition=fundamental","pubTime":"2024-11-20 19:36","pubTimestamp":1732102569,"startTime":"0","endTime":"0","summary":"Sage Therapeutics' rare disease drug fails mid-stage study  Nov 20  - Sage Therapeutics SAGE.O said on Wednesday its experimental drug failed to meet the main goal in a mid-stage study testing the drug in patients with a rare, genetic neurological condition called Huntington's disease.      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