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UpStream Bio Inc.

9.23

-0.2050-2.17%

Pre-market: 9.240.0100+0.11%05:26 EDT

Volume:723.12K

Turnover:6.66M

Market Cap:498.78M

PE:-4.06

High:9.76

Open:9.32

Low:8.93

Close:9.44

52wk High:33.68

52wk Low:5.14

Shares:54.04M

Float Shares:31.42M

Volume Ratio:0.67

T/O Rate:2.30%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.2740

EPS(LYR):-5.5835

ROE:-40.80%

ROA:-28.15%

PB:1.32

PE(LYR):-1.65

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Overview Company News Filings

Upstream Bio (UPB) Is Up 15.4% After Analyst Upgrades on Verekitug Data Is Sentiment Justified?

Simply Wall St.

Upstream Bio, Inc. (UPB) Receives a Buy from Piper Sandler

Upstream Bio (UPB): Fresh Data and Analyst Coverage Spark New Questions on Valuation

Simply Wall St.

Upstream Bio Initiated at Buy by Truist Securities

Upstream Bio initiated with a Buy at Truist

Why Upstream Bio (UPB) Is Up 6.5% After Positive Phase 2 Results for Verekitug in Respiratory Diseases

Simply Wall St.

HBM Healthcare Investments Reports CHF 236 Million Quarterly Profit, NAV Up 16.4%

Upstream Bio’s verekitug shows prevention of TSLP binding in respiratory disease

Upstream Bio Announces Promising Phase 2 Clinical Results for Verekitug in Severe Respiratory Diseases at ERS Congress

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The com...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/upstream-bio-inc-upb-receives-a-buy-from-piper-sandler-blurbs?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/upstream-bio-inc-upb-receives-a-buy-from-piper-sandler-blurbs?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["UPB","BK4139"],"gpt_icon":0},{"id":"2576432023","title":"Upstream Bio (UPB): Fresh Data and Analyst Coverage Spark New Questions on Valuation","url":"https://stock-news.laohu8.com/highlight/detail?id=2576432023","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2576432023?lang=en_us&edition=fundamental","pubTime":"2025-10-19 07:13","pubTimestamp":1760829230,"startTime":"0","endTime":"0","summary":"Upstream Bio (UPB) recently made headlines after presenting fresh structural and mechanistic insights for its promising drug candidate, verekitug, at a major scientific congress. 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But it’s worth noting the 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Bio Initiated at Buy by Truist Securities","url":"https://stock-news.laohu8.com/highlight/detail?id=2575721511","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2575721511?lang=en_us&edition=fundamental","pubTime":"2025-10-14 21:19","pubTimestamp":1760447940,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/UPB/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  October 14, 2025 09:19 ET (13:19 GMT)","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","UPB"],"gpt_icon":0},{"id":"2575029664","title":"Upstream Bio initiated with a Buy at Truist","url":"https://stock-news.laohu8.com/highlight/detail?id=2575029664","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2575029664?lang=en_us&edition=fundamental","pubTime":"2025-10-14 18:15","pubTimestamp":1760436942,"startTime":"0","endTime":"0","summary":"Truist initiated coverage of Upstream Bio (UPB) with a Buy rating and $47 price target Verekitug offers similarly robust efficacy as other TSLP-rec...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/upstream-bio-initiated-with-a-buy-at-truist-thefly?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/upstream-bio-initiated-with-a-buy-at-truist-thefly?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","UPB"],"gpt_icon":0},{"id":"2574856004","title":"Why Upstream Bio (UPB) Is Up 6.5% After Positive Phase 2 Results for Verekitug in Respiratory Diseases","url":"https://stock-news.laohu8.com/highlight/detail?id=2574856004","media":"Simply Wall St.","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2574856004?lang=en_us&edition=fundamental","pubTime":"2025-10-11 02:28","pubTimestamp":1760120883,"startTime":"0","endTime":"0","summary":"At the European Respiratory Society Congress held in Amsterdam from September 27 to October 1, 2025, Upstream Bio presented new structural and mechanistic data for verekitug, highlighting its potent pharmacodynamic activity against the TSLP receptor and positive Phase 2 results in chronic rhinosinusitis with nasal polyps.\nThis advancement, alongside updates on multiple ongoing trials in asthma and COPD, underscores the momentum of Upstream Bio’s clinical pipeline for respiratory...","market":"nz","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-upb/upstream-bio/news/why-upstream-bio-upb-is-up-65-after-positive-phase-2-results","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-upb/upstream-bio/news/why-upstream-bio-upb-is-up-65-after-positive-phase-2-results","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4139","UPB"],"gpt_icon":0},{"id":"2572535555","title":"HBM Healthcare Investments Reports CHF 236 Million Quarterly Profit, NAV Up 16.4%","url":"https://stock-news.laohu8.com/highlight/detail?id=2572535555","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2572535555?lang=en_us&edition=fundamental","pubTime":"2025-10-01 23:49","pubTimestamp":1759333787,"startTime":"0","endTime":"0","summary":"Net asset value  per share increased by 16.4% in the second quarter of fiscal year 2025/2026 to CHF 251.78. The company reported a quarterly profit of CHF 236 million, offsetting the currency-related loss from the first quarter. For the first half of the current fiscal year, the company expects a profit of CHF 96 million and an increase in NAV of 6.1% in Swiss francs . The share price rose by 4.0% during the same period and trades at a 28% discount to NAV. The positive second quarter results are mainly attributed to developments in listed portfolio companies, including clinical study results from Abivax, Mineralys, Upstream Bio, and UniQure, as well as acquisition offers for Merus, Y-mAbs Therapeutics, and 89Bio. Foreign currency effects had no material impact on the second quarter's performance. The final half-year results will be published on October 24, 2025.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251001:nNDL5tnLj9:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["MRUS","UPB","LU0889565916.HKD","BK4585","LU0109394709.USD","ETNB","QURE","BK4139","YMAB","LU0320765992.SGD"],"gpt_icon":0},{"id":"2571345035","title":"Upstream Bio’s verekitug shows prevention of TSLP binding in respiratory disease","url":"https://stock-news.laohu8.com/highlight/detail?id=2571345035","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2571345035?lang=en_us&edition=fundamental","pubTime":"2025-09-30 18:15","pubTimestamp":1759227319,"startTime":"0","endTime":"0","summary":"Upstream Bio (UPB) presented structural and mechanistic data showing verekitug’s potent pharmacodynamic activity through its approach of targeting ...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/upstream-bios-verekitug-shows-prevention-of-tslp-binding-in-respiratory-disease-thefly?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/upstream-bios-verekitug-shows-prevention-of-tslp-binding-in-respiratory-disease-thefly?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["UPB","BK4139","TSLP"],"gpt_icon":0},{"id":"2571731460","title":"Upstream Bio Announces Promising Phase 2 Clinical Results for Verekitug in Severe Respiratory Diseases at ERS Congress","url":"https://stock-news.laohu8.com/highlight/detail?id=2571731460","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2571731460?lang=en_us&edition=fundamental","pubTime":"2025-09-30 16:15","pubTimestamp":1759220109,"startTime":"0","endTime":"0","summary":"Upstream Bio Inc. , a clinical-stage biotechnology company focused on treatments for inflammatory diseases, has presented new data on its investigational drug verekitug at the European Respiratory Society  Congress 2025. The data highlight verekitug's unique mechanism of action, which involves targeting the thymic stromal lymphopoietin  receptor and preventing TSLP binding by occupying its ligand binding sites. Structural and mechanistic studies reveal that verekitug outcompetes TSLP even in the presence of preformed heterodimeric receptor complexes, supporting its potential for differentiated therapeutic effects in a variety of severe respiratory diseases driven by TSLP. Clinical findings from a recent Phase 2 study in chronic rhinosinusitis with nasal polyps indicate statistically significant and clinically meaningful effects with dosing every 12 weeks. Additional Phase 2 top-line data in severe asthma are expected in the first quarter of 2026. The full presentation is available on t","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250930:nNDL2834Y1:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4112","LU2210149790.SGD","BK4585","BK4588","IE00B3QW5Z07.USD","IE00BGHQF748.EUR","LU0314104364.USD","LU2095319765.USD","UPB","IE00B64PRP62.GBP","NDAQ","BK4139","IE00BKPKM429.USD","LU2210150020.SGD"],"gpt_icon":1}],"pageSize":20,"totalPage":3,"pageCount":3,"totalSize":49,"code":"91000000","status":"200"}]}}