GSK(GSK.US)ADC疗法3期临床结果积极延长难治性癌症患者生命

智通财经

2024-11-15

智通财经APP获悉，GSK(GSK.US)今日宣布，其抗体偶联药物(ADC)Blenrep(belantamab mafodotin)在3期临床试验DREAMM-7的预定中期分析中获得了积极结果。该试验评估了Blenrep联合硼替佐米和地塞米松(BorDex)作为复发或难治性多发性骨髓瘤的二线或更晚期治疗的效果。试验达到了总生存期(OS)的关键次要终点，显示出Blenrep联合BorDex与标准治疗方案相比，显著降低了患者死亡风险。包括安全性数据在内的中期分析结果将于即将召开的第66届美国血液学会(ASH)年会上发布。

Blenrep是一种靶向B细胞成熟抗原(BCMA)的抗体偶联药物，由人源化抗BCMA单克隆抗体与细胞毒性载荷auristatin F通过不可切割的连接子结合而成。

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