Health care stocks were flat to higher pre-bell Tuesday as the iShares Biotechnology ETF (IBB) was flat and the Health Care Select Sector SPDR Fund (XLV) was up 0.2%.

Sangamo Therapeutics (SGMO) shares fell past 52% after the company said it will regain full development and commercialization rights for giroctocogene fitelparvovec as Pfizer (PFE) decided to terminate the collaboration and licensing agreement for the prospective hemophilia A gene therapy.

Corcept Therapeutics (CORT) shares rose by more than 5% after the company said it filed a new drug application to the US Food and Drug Administration for relacorilant to treat patients with endogenous hypercortisolism.

Acadia Pharmaceuticals (ACAD) is set to join the S&P SmallCap 600 index on Jan. 3, replacing Independent Bank Group (IBTX), S&P Dow Jones Indices said. Acadia Pharmaceuticals shares were up over 8% premarket.