The broad market exchange-traded fund SPDR S&P 500 ETF Trust (SPY) was down 0.1% and the actively traded Invesco QQQ Trust (QQQ) retreated marginally by 0.04% in Friday's premarket activity, amid investor concerns over potential trade policy changes and anticipation of upcoming economic data and corporate earnings reports.

US stock futures were also lower, with S&P 500 Index futures down 0.1%, Dow Jones Industrial Average futures slipping 0.2%, and Nasdaq futures losing 0.1% before the start of regular trading.

The flash S&P Global PMI composite report for January will be released at 9:45 am ET, followed by the December existing home sales bulletin and the University of Michigan consumer sentiment release for January at 10 am ET.

The Baker Hughes domestic oil-and-gas rig count is slated for a 1 pm ET release.

In premarket activity, bitcoin was up by 2.1% and the cryptocurrency fund ProShares Bitcoin Strategy ETF (BITO) was 2.4% higher.

Power Play:

Technology

Technology Select Sector SPDR Fund (XLK) advanced 0.01%, and the iShares US Technology ETF (IYW) was 0.3% higher, while the iShares Expanded Tech Sector ETF (IGM) was up 1.6%. Among semiconductor ETFs, SPDR S&P Semiconductor ETF (XSD) was down 0.4%, while the iShares Semiconductor ETF (SOXX) declined 0.3%.

Twilio (TWLO) shares were up more than 18% in recent Friday premarket activity after the company said Thursday it expects to report Q4 non-GAAP diluted earnings above its guidance range and 11% higher revenue.

Winners and Losers:

Health Care

The Health Care Select Sector SPDR Fund (XLV) retreated 0.2%. The Vanguard Health Care Index Fund (VHT) was flat while the iShares US Healthcare ETF (IYH) gained 0.1%. The iShares Biotechnology ETF (IBB) was flat.

Novo Nordisk (NVO) stock was up more than 12% premarket after the company said its phase 1b/2a clinical trial with amycretin, a potential weight loss drug, showed positive results.

Financial

Financial Select Sector SPDR Fund (XLF) declined 0.1%. Direxion Daily Financial Bull 3X Shares (FAS) was down 0.4%, while its bearish counterpart Direxion Daily Financial Bear 3X Shares (FAZ) was 0.4% higher.

Lakeland Financial (LKFN) shares were up nearly 2% pre-bell Friday after the company reported lower Q4 core operational earnings and revenue.

Energy

The iShares US Energy ETF (IYE) was inactive, while the Energy Select Sector SPDR Fund (XLE) was up by 0.02%.

NextEra Energy (NEE) stock was down nearly 2% before Friday's opening bell after the company reported lower Q4 operating revenue that also trailed analyst estimates.

Industrial

Industrial Select Sector SPDR Fund (XLI) retreated 0.1% while the Vanguard Industrials Index Fund (VIS) was flat and the iShares US Industrials ETF (IYJ) was inactive.

Boeing (BA) stock was down 1.2% before the opening bell as the plane maker reported a preliminary Q4 loss due in part to the strike by the International Association of Machinists and Aerospace Workers union last year, among other factors.

Consumer

The Consumer Staples Select Sector SPDR Fund (XLP) was up 0.1%, while the Vanguard Consumer Staples Fund (VDC) advanced 0.1%. The iShares US Consumer Staples ETF (IYK) was inactive, and the Consumer Discretionary Select Sector SPDR Fund (XLY) gained marginally by 0.01%. The VanEck Retail ETF (RTH) was down by 0.7%, while the SPDR S&P Retail ETF (XRT) was flat.

Rivian Automotive (RIVN) shares were up 1% pre-bell after media reports cited Rivian Chief Software Officer Wassym Bensaid saying that the company's joint venture with Volkswagen may supply its software and electrical architecture to other automakers.

Commodities

Front-month US West Texas Intermediate crude oil gained 0.5% to reach $74.99 per barrel on the New York Mercantile Exchange. Natural gas fell 2.8% to $3.83 per 1 million British Thermal Units. United States Oil Fund (USO) advanced 1%, while the United States Natural Gas Fund (UNG) was 2.7% lower.

Gold futures for February gained 0.7% to reach $2,784.80 an ounce on the Comex, and silver futures advanced 1.8% to $31.40 an ounce. SPDR Gold Shares (GLD) were flat, while the iShares Silver Trust (SLV) was 1.4% higher.