** Medical device maker Intuitive Surgical's ISRG.O shares up 3% at $492.79 after Q1 results beat

** Co posts adj. EPS of $1.81, beating analysts' estimates of $1.72 - as per data compiled by LSEG

** Reports Q1 revenue of $2.25 bln versus estimates of $2.19 bln

** ISRG projects 2025 adj. gross profit margin in a range of 65% to 66.5% of revenue, lower than last year's 69.1% due to tariffs

** Co says U.S. tariffs to weigh on its business for the rest of the year

** At least 12 brokerages cut target price on stock, citing tariffs; J.P. Morgan cuts PT to $605 from $675

** Piper Sandler lowers PT to $575 from $670; cites tariff-related lowered gross profit margin guidance

** "While the tariff-related GM guide-down is a touch disappointing - we believe this headwind will be transitory and that ISRG has essentially built-in a 'worst case' scenario," -brokerage

** 21 out of 33 brokerages rate stock "buy" or higher, 12 "hold"; Median PT is $607.45 - data compiled by LSEG

** Including current move, ISRG down 5.6% YTD

(Reporting by Twesha Dikshit)

((Twesha.Dikshit@thomsonreuters.com))