CytomX Therapeutics

0.6308

-0.0007-0.11%

Volume:301.43K

Turnover:189.16K

Market Cap:50.53M

PE:1.67

High:0.6450

Open:0.6315

Low:0.6188

Close:0.6315

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Sarepta will soon start screening and dosing patients in the first-in-human clinical SRP-9005-101  study, to evaluate its investigational gene therapy SRP-9005 for LGMD type 2C/R5 .SRPT also announced completion of enrollment and dosing in the phase I proof-of-concept SRP-9004-102  study, which is evaluating SRP-9004 in patients with LGMD type 2D/R3 .The company also reiterated its plans to report data from the late-stage EMERGENE study, evaluating SRP-9003 in patients with LGMD type 2E/R4 , by first-half 2025. This study’s primary endpoint is the biomarker expression of the beta-sarcoglycan protein, whose absence is the sole cause of the disease. 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Per the FDA, the purpose of granting this designation is to ‘get important new drugs to the patient earlier.’。In the past 60 days, estimates for CytomX Therapeutics’ 2025 EPS have improved from a loss of 31 cents to a profit of 25 cents. 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The therapy has been developed in collaboration with pharma giant Roche RHHBY.This hold has been placed in response to a patient’s death post-treatment with Elevidys, which was reported last month. Though the death was due to acute liver failure , Sarepta believes that the patient’s recent CMV infection might have contributed to the outcome. Investigation is still ongoing.In a letter to the World Duchenne Organization, Roche mentioned that the companies are pausing enrollment and dosing of study participants in three studies evaluating the therapy at the EU study sites. This hold will remain ‘until the analysis into the cause of death is complete.’。SRPT and RHHBY entered into a licensing agreement in 2019 to develop Elevidys. 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