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Ionis Pharmaceuticals

71.19

-1.1500-1.59%

Volume:1.97M

Turnover:141.00M

Market Cap:11.76B

PE:-29.91

High:74.16

Open:73.21

Low:70.42

Close:72.34

52wk High:86.74

52wk Low:23.95

Shares:165.19M

Float Shares:164.00M

Volume Ratio:0.80

T/O Rate:1.20%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.3800

EPS(LYR):-2.3812

ROE:-70.80%

ROA:-7.31%

PB:24.04

PE(LYR):-29.90

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Overview Company News Filings

Ionis Pharmaceuticals Is Maintained at Overweight by Wells Fargo

The Year-End 2025 Biotech Rally And What It Means For 2026

Benzinga_recent_news

Will FDA Approval of Tryngolza and Analyst Support Change Ionis Pharmaceuticals' (IONS) Narrative?

Simply Wall St.

Cathie Wood Dumps $11 Milllion Worth of Tesla Stock While Doubling Down on These Notable Crypto Plays

Ionis Pharmaceuticals Is Maintained at Outperform by RBC Capital

RBC Raises Price Target on Ionis Pharmaceuticals to $95 From $82, Keeps Outperform Rating

MT Newswires Live

Is It Too Late to Consider Ionis After Its 126% Surge in 2025?

Simply Wall St.

Ionis Pharmaceuticals Is Maintained at Outperform by Leerink Partners

Ionis Pharmaceuticals Inc : Leerink Partners Raises Target Price to $100 From $85

THOMSON REUTERS

Ionis Pharmaceuticals (IONS): Revisiting Valuation After a Strong 1-Year Share Price Surge

Simply Wall St.

Ionis Pharmaceuticals Is Maintained at Buy by B of A Securities

Ionis Pharmaceuticals Inc : Bofa Global Research Raises Price Objective to $97 From $86

THOMSON REUTERS

Ionis Pharmaceuticals Director Joseph H. Wender Reports Sale of Common Shares

Pharvaris Pill Provides Rapid Relief In Patients With Rare Swelling Attacks, Data Shows

Benzinga_recent_news

FDA Grants Breakthrough Therapy Designation to Ionis Pharmaceuticals' Zilganersen for Alexander Disease

Ionis Receives U.S. FDA Breakthrough Therapy Designation for Zilganersen for Alexander Disease (Axd)

THOMSON REUTERS

Ionis Pharmaceuticals Inc - on Track to Submit Nda for Zilganersen in Q1 2026

THOMSON REUTERS

Ionis Pharmaceuticals (IONS): Valuation Perspective Following FDA Breakthrough Therapy Milestone for Olezarsen

Simply Wall St.

Ionis Pharmaceuticals Shares Reverse Premarket Course, Last Down 2.4%

THOMSON REUTERS

Ionis Pharmaceuticals Shares up 3.5% Premarket After Co Receives FDA Breakthrough Therapy Designation for Olezarsen for Shtg

THOMSON REUTERS

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Pharmaceuticals Is Maintained at Overweight by Wells Fargo","url":"https://stock-news.laohu8.com/highlight/detail?id=2601636831","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2601636831?lang=en_us&edition=fundamental","pubTime":"2026-01-06 02:55","pubTimestamp":1767639300,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  January 05, 2026 13:55 ET (18:55 GMT)","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"gpt_icon":0},{"id":"2600708537","title":"The Year-End 2025 Biotech Rally And What It Means For 2026","url":"https://stock-news.laohu8.com/highlight/detail?id=2600708537","media":"Benzinga_recent_news","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2600708537?lang=en_us&edition=fundamental","pubTime":"2025-12-31 23:54","pubTimestamp":1767196440,"startTime":"0","endTime":"0","summary":"Biotechnology stocks are wrapping up 2025 on a high note, bouncing back from a rocky start to deliver some of the year’s most impressive gains. What began as a sector weighed down by tariff fears and political noise has transformed into one of the market’s standout performers, powered by deal making, drug approvals, and breakthrough clinical results. The big question heading into 2026 is simple: can this momentum last?The performance metrics speak volumes. The iShares Biotechnology ETF  has climbed 29.51% year to date through December 29, while the State Street SPDR S&P Biotech ETF  has done even better with gains around 35.84%. The Nasdaq Biotechnology Index sits at 5,766.59, marking a 34% jump for the year.Regulatory wins provided another boost. The FDA greenlit 44 new therapies in 2025, with 26 approvals coming in the second half alone. December saw notable wins including Cytokinetics Incorporated’s  Myqorzo for a heart condition, marking the company’s first approval after 27 years ","market":"sh","thumbnail":"/next-assets/images/benzinga-post-card-placeholder.svg?optimize=medium&dpr=2&auto=webp&width=240","type":0,"news_type":0,"thumbnails":["/next-assets/images/benzinga-post-card-placeholder.svg?optimize=medium&dpr=2&auto=webp&width=240"],"rights":{"source":"benzinga_recent_news","url":"https://www.benzinga.com/news/25/12/49650052/the-year-end-2025-biotech-rally-and-what-it-means-for-2026","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.benzinga.com/news/25/12/49650052/the-year-end-2025-biotech-rally-and-what-it-means-for-2026","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"benzinga_recent_news","symbols":["NVS","SG9999014906.USD","QID","LU0471298694.HKD","BK4581","VRNA","BK4532","PFE","GPCR","MNQmain","MRK","TQQQ","NVIW.SI","LU0306807586.USD","SQQQ","LU0432979614.USD","JNJ","QLD","IE00BVYPNW00.USD","PSQ","LU1037948897.HKD","LU2089984988.USD","IE00BBT3K403.USD","BK4505","IBB","SG9999014880.SGD",".IXIC","NQmain","EYPT","ITCI","IE0005OL40V9.USD","LU2430703178.SGD","IONS","IE00B1BXHZ80.USD","OMER","LU2592432038.USD","MNPR","LU0823434740.USD","IE00BJT1NW94.SGD","RNA","LU1935042991.SGD","TSYW.SI","LU0256863811.USD","LU2063271972.USD","USAW.SI","LU1116320737.USD","CYTK","USJW.SI"],"gpt_icon":1},{"id":"2593102073","title":"Will FDA Approval of Tryngolza and Analyst Support Change Ionis Pharmaceuticals' (IONS) Narrative?","url":"https://stock-news.laohu8.com/highlight/detail?id=2593102073","media":"Simply Wall St.","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2593102073?lang=en_us&edition=fundamental","pubTime":"2025-12-22 13:17","pubTimestamp":1766380653,"startTime":"0","endTime":"0","summary":"In recent months, Ionis Pharmaceuticals secured FDA approval for Tryngolza, its first independently launched RNA-targeted therapy for familial chylomicronemia syndrome, while multiple research firms reiterated positive views on the company’s prospects. This combination of regulatory success and renewed analyst confidence highlights Ionis’s evolution from a primarily R&D-focused biotech toward a more fully fledged commercial organization.\nNow, we’ll explore how Ionis’s first independent...","market":"hk","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/will-fda-approval-of-tryngolza-and-analyst-support-change-io","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/will-fda-approval-of-tryngolza-and-analyst-support-change-io","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2592404139","title":"Cathie Wood Dumps $11 Milllion Worth of Tesla Stock While Doubling Down on These Notable Crypto Plays","url":"https://stock-news.laohu8.com/highlight/detail?id=2592404139","media":"Benzinga","labels":["shareholding","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592404139?lang=en_us&edition=fundamental","pubTime":"2025-12-19 15:00","pubTimestamp":1766127600,"startTime":"0","endTime":"0","summary":"On Thursday, Cathie Wood-led Ark Invest made significant trades involving Tesla, Coinbase, and Brera Holdings.","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"043923b8d36f8cfd5c3ba60252c2c8ad","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.benzinga.com/etfs/broad-u-s-equity-etfs/25/12/49497703/cathie-wood-dumps-11-milllion-worth-of-tesla-stock-while-doubling-down-on-these-notable-crypto-plays","is_publish_highlight":true,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","LU0345770308.USD","LU1435385759.SGD","BK4544","LU0320765059.SGD","BK4555","LU1429558221.USD","IE00BWXC8680.SGD","LU2471134523.USD","BK4581","BK4108","BK4543","LU2023250330.USD","LU1778281490.HKD","BK4588","SG9999015952.SGD","LU1720051017.SGD","LU2360107671.USD","LU2326559502.SGD","LU0466842654.USD","COIN","ADPT","BK4112","IE00B1XK9C88.USD","IE00B19Z9505.USD","IE00B19Z8X17.USD","SG9999015986.USD","LU0198837287.USD","LU1720051108.HKD","LU1548497426.USD","BK4600","LU2417539215.USD","IE00BJLML261.HKD","LU2471134952.CNY","LU1861559042.SGD","LU0820562030.AUD","LU2360106780.USD","LU0077335932.USD","LU2236285917.USD","LU2471134796.USD","LU0097036916.USD","LU2456880835.USD","BK4516","LU0820561909.HKD","IE00B19Z8W00.USD","LU2602419157.SGD","IE00BK4W5M84.HKD","IE00B1BXHZ80.USD","IE00BK4W5L77.USD","LU1839511570.USD","IE0034235303.USD","LU0234570918.USD","LU0708995401.HKD","BK4598","LU0820561818.USD","LU2357305700.SGD","LU1551013425.SGD","LU0348723411.USD","IE00BSNM7G36.USD","SLMT","BK4533","BK4099","LU1852331112.SGD","LU1861220207.SGD","LU1629891620.HKD","LU2087621335.USD","LU0719512351.SGD","LU0053666078.USD","LU1861220033.SGD","LU2249611893.SGD","BK4612","LU1145028129.USD","BK4548","LU1066051811.HKD","SG9999015978.USD","LU0323591593.USD","LU0689472784.USD","BK4592","BK4554","BK4585","LU2420271590.USD","SG9999015945.SGD","LU2360107168.USD","LU2756315664.SGD","BK4539","LU0823414478.USD","LU1066053197.SGD","LU0109391861.USD","LU2750360641.GBP","LU1066051225.USD","LU0672654240.SGD","LU1267930730.SGD","LU1232071149.USD","BK4535","LU2213496289.HKD","LU2063271972.USD","LU0823411888.USD","BK4596","BK4574","LU2250418816.HKD","LU0234572021.USD","LU0082616367.USD","BK4527","LU2750360997.AUD","LU1366192091.USD","LU2756315318.SGD","BK4511","BK4551","LU2471134879.HKD","LU2403377893.USD","LU2108987350.USD","BK4550","LU0943347566.SGD","BK4604","RXRX","LU1914381329.SGD","LU0345770993.USD","BK4595","TSLA","LU1861215975.USD","LU0056508442.USD","LU0345769631.USD","LU2462157665.USD","BK4534","LU0345769128.USD","LU0210536198.USD","LU1674673428.USD","LU0316494557.USD","LU2896262040.SGD","LU1861558580.USD","LU1674673691.USD","LU1066051498.USD","LU1861217088.USD","LU1551013342.USD","LU0964807845.USD","LU2290526834.HKD"],"gpt_icon":1},{"id":"2592919546","title":"Ionis Pharmaceuticals Is Maintained at Outperform by RBC Capital","url":"https://stock-news.laohu8.com/highlight/detail?id=2592919546","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592919546?lang=en_us&edition=fundamental","pubTime":"2025-12-17 23:12","pubTimestamp":1765984320,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 17, 2025 10:12 ET (15:12 GMT)","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"gpt_icon":0},{"id":"2592997989","title":"RBC Raises Price Target on Ionis Pharmaceuticals to $95 From $82, Keeps Outperform Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2592997989","media":"MT Newswires Live","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592997989?lang=en_us&edition=fundamental","pubTime":"2025-12-17 20:36","pubTimestamp":1765974961,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals (IONS) has an average rating of overweight and mean price target of $89.37, according to analysts polled by FactSet.(MT Newswires covers equity, commodity and economic research f","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate","earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"express","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["IONS"],"gpt_icon":0},{"id":"2592696403","title":"Is It Too Late to Consider Ionis After Its 126% Surge in 2025?","url":"https://stock-news.laohu8.com/highlight/detail?id=2592696403","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592696403?lang=en_us&edition=fundamental","pubTime":"2025-12-17 13:21","pubTimestamp":1765948910,"startTime":"0","endTime":"0","summary":"If you are wondering whether Ionis Pharmaceuticals is still worth considering after its huge run, or if the easy money has already been made, this breakdown is for you.\nThe stock has risen 125.9% year to date and is up 108.0% over the last year, even after a recent 0.6% slip over the past week and a 9.5% gain in the last month.\nThose gains have come alongside growing optimism around its antisense drug pipeline and partnerships with major pharma names, as investors reassess the long term...","market":"hk","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/is-it-too-late-to-consider-ionis-after-its-126-surge-in-2025","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/is-it-too-late-to-consider-ionis-after-its-126-surge-in-2025","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4139","DCF","IONS"],"gpt_icon":0},{"id":"2591621111","title":"Ionis Pharmaceuticals Is Maintained at Outperform by Leerink Partners","url":"https://stock-news.laohu8.com/highlight/detail?id=2591621111","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2591621111?lang=en_us&edition=fundamental","pubTime":"2025-12-16 04:55","pubTimestamp":1765832100,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 15, 2025 15:55 ET (20:55 GMT)","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"gpt_icon":0},{"id":"2591645516","title":"Ionis Pharmaceuticals Inc : Leerink Partners Raises Target Price to $100 From $85","url":"https://stock-news.laohu8.com/highlight/detail?id=2591645516","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2591645516?lang=en_us&edition=fundamental","pubTime":"2025-12-15 19:59","pubTimestamp":1765799952,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251215:nFWN3XL0HI:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2590533895","title":"Ionis Pharmaceuticals (IONS): Revisiting Valuation After a Strong 1-Year Share Price Surge","url":"https://stock-news.laohu8.com/highlight/detail?id=2590533895","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590533895?lang=en_us&edition=fundamental","pubTime":"2025-12-10 21:31","pubTimestamp":1765373518,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals (IONS) has quietly turned into one of the market’s better comeback stories, with the stock up sharply over the past year even as near term returns cooled this week.\nSee our latest analysis for Ionis Pharmaceuticals.\nAfter a sharp run that has pushed the share price to 78.86 dollars and delivered a year to date share price return of 127.33 percent, this week’s pullback simply cools the pace. A 1 year total shareholder return of 107.58 percent and 3 year total shareholder...","market":"nz","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/ionis-pharmaceuticals-ions-revisiting-valuation-after-a-stro","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/ionis-pharmaceuticals-ions-revisiting-valuation-after-a-stro","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2590473325","title":"Ionis Pharmaceuticals Is Maintained at Buy by B of A Securities","url":"https://stock-news.laohu8.com/highlight/detail?id=2590473325","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590473325?lang=en_us&edition=fundamental","pubTime":"2025-12-10 02:09","pubTimestamp":1765303740,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 09, 2025 13:09 ET (18:09 GMT)","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"gpt_icon":0},{"id":"2590343259","title":"Ionis Pharmaceuticals Inc : Bofa Global Research Raises Price Objective to $97 From $86","url":"https://stock-news.laohu8.com/highlight/detail?id=2590343259","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590343259?lang=en_us&edition=fundamental","pubTime":"2025-12-09 20:04","pubTimestamp":1765281856,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251209:nFWN3XF0FP:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588078114","title":"Ionis Pharmaceuticals Director Joseph H. Wender Reports Sale of Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2588078114","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588078114?lang=en_us&edition=fundamental","pubTime":"2025-12-04 08:01","pubTimestamp":1764806491,"startTime":"0","endTime":"0","summary":"Joseph H. Wender, Director at Ionis Pharmaceuticals Inc., reported a disposal of common shares of the company. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on December 03, 2025, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251204:nNDL9wqt8r:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Ionis Pharmaceuticals Director Joseph H. 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This designation is granted to therapies that treat serious or life-threatening conditions and have shown preliminary clinical evidence of substantial improvement over existing treatments. Zilganersen demonstrated statistically significant and clinically meaningful results in a pivotal study, including stabilization of gait speed in affected patients. Ionis plans to submit a New Drug Application  to the FDA in the first quarter of 2026 and is preparing to initiate an Expanded Access Program in the U.S. There are currently no approved disease-modifying treatments for Alexander disease.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purpos","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251202:nNDL2QRdNf:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588308940","title":"Ionis Receives U.S. FDA Breakthrough Therapy Designation for Zilganersen for Alexander Disease (Axd)","url":"https://stock-news.laohu8.com/highlight/detail?id=2588308940","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588308940?lang=en_us&edition=fundamental","pubTime":"2025-12-02 20:00","pubTimestamp":1764676801,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251202:nTUA30VGRD:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588103087","title":"Ionis Pharmaceuticals Inc - on Track to Submit Nda for Zilganersen in Q1 2026","url":"https://stock-news.laohu8.com/highlight/detail?id=2588103087","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588103087?lang=en_us&edition=fundamental","pubTime":"2025-12-02 20:00","pubTimestamp":1764676801,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251202:nTUA30VGRD:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588365770","title":"Ionis Pharmaceuticals (IONS): Valuation Perspective Following FDA Breakthrough Therapy Milestone for Olezarsen","url":"https://stock-news.laohu8.com/highlight/detail?id=2588365770","media":"Simply Wall St.","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588365770?lang=en_us&edition=fundamental","pubTime":"2025-12-02 01:18","pubTimestamp":1764609525,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals (IONS) stock caught a fresh wave of attention after the FDA granted Breakthrough Therapy designation to its drug candidate olezarsen for severe hypertriglyceridemia. 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