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Ionis Pharmaceuticals

71.10

-0.5700-0.80%

Volume:238.56K

Turnover:16.95M

Market Cap:11.75B

PE:-29.87

High:71.64

Open:71.40

Low:70.51

Close:71.67

52wk High:86.74

52wk Low:23.95

Shares:165.19M

Float Shares:164.00M

Volume Ratio:0.96

T/O Rate:0.15%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.3800

EPS(LYR):-2.3812

ROE:-70.80%

ROA:-7.31%

PB:24.01

PE(LYR):-29.86

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Overview Company News Filings

Ionis Pharmaceuticals Shares up 3.5% Premarket After Co Receives FDA Breakthrough Therapy Designation for Olezarsen for Shtg

THOMSON REUTERS

FDA Grants Breakthrough Therapy Designation to Ionis Pharmaceuticals' Olezarsen for Severe Hypertriglyceridemia

Ionis Pharmaceuticals Inc: on Track to Submit Supplemental New Drug Application by End of Year

THOMSON REUTERS

Ionis Receives U.S. FDA Breakthrough Therapy Designation for Olezarsen for Severe Hypertriglyceridemia (Shtg)

THOMSON REUTERS

Metagenomi to Present Preclinical Data Supporting New Collaboration Target of APOC3 with Ionis Pharmaceuticals at Upcoming Nature Conference

Why Ionis Pharmaceuticals (IONS) Is Up 8.7% After Donidalorsen EMA Milestone and $700 Million Offering News

Simply Wall St.

Ionis Pharmaceuticals EVP Chief Human Resources Officer Shannon L. Devers Reports Sale of Common Shares

Ionis Pharmaceuticals Director Joseph Klein III Reports Disposal of Common Shares

Director’s Multi-Million Dollar Stock Sale Shakes Ionis Pharmaceuticals

Ionis Pharmaceuticals Director Joan E. Herman Reports Sale of Common Shares

Ionis Announces Proposed Convertible Offering To Refinance 2026 Convertible Notes

Arrowhead Pharmaceuticals Poised for Commercial Transition After First FDA Approval, RBC Says

MT Newswires Live

Ionis Pharmaceuticals (IONS) Gets a Hold from Bernstein

US FDA approves Arrowhead's genetic disorder drug

Ionis Pharmaceuticals Completes $770M Convertible Notes Offering

Ionis Pharmaceuticals Announces $700 Million Convertible Senior Notes Offering

Biogen Gets CHMP Backing for Higher-Dose Spinraza

Ionis Pharmaceuticals announces CHMP opinion recommending Dawnzera approval

Ionis Pharmaceuticals Says Dawnzera Recommended for Approval in EU for Hereditary Angioedema

MT Newswires Live

Ionis Pharmaceuticals Wins CHMP Backing for DAWNZERA in Hereditary Angioedema Prevention

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Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via Business Wire  on December 01, 2025, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251201:nNDL17HMR5:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588724216","title":"Ionis Pharmaceuticals Inc: on Track to Submit Supplemental New Drug Application by End of Year","url":"https://stock-news.laohu8.com/highlight/detail?id=2588724216","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588724216?lang=en_us&edition=fundamental","pubTime":"2025-12-01 20:00","pubTimestamp":1764590400,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251201:nTUA91LG5Z:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588240724","title":"Ionis Receives U.S. FDA Breakthrough Therapy Designation for Olezarsen for Severe Hypertriglyceridemia (Shtg)","url":"https://stock-news.laohu8.com/highlight/detail?id=2588240724","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588240724?lang=en_us&edition=fundamental","pubTime":"2025-12-01 20:00","pubTimestamp":1764590400,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251201:nTUA91LG5Z:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588722311","title":"Metagenomi to Present Preclinical Data Supporting New Collaboration Target of APOC3 with Ionis Pharmaceuticals at Upcoming Nature Conference","url":"https://stock-news.laohu8.com/highlight/detail?id=2588722311","media":"GlobeNewswire","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588722311?lang=en_us&edition=fundamental","pubTime":"2025-12-01 20:00","pubTimestamp":1764590400,"startTime":"0","endTime":"0","summary":"EMERYVILLE, Calif., Dec.  01, 2025  (GLOBE NEWSWIRE) -- Metagenomi, Inc. (Nasdaq: MGX) (the “Company”), an in vivo genome editing company capitalizing on its proprietary technologies to create curativ","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2025/12/01/3196850/0/en/Metagenomi-to-Present-Preclinical-Data-Supporting-New-Collaboration-Target-of-APOC3-with-Ionis-Pharmaceuticals-at-Upcoming-Nature-Conference.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","IONS","MGX"],"gpt_icon":0},{"id":"2587692177","title":"Why Ionis Pharmaceuticals (IONS) Is Up 8.7% After Donidalorsen EMA Milestone and $700 Million Offering News","url":"https://stock-news.laohu8.com/highlight/detail?id=2587692177","media":"Simply Wall St.","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2587692177?lang=en_us&edition=fundamental","pubTime":"2025-11-30 00:14","pubTimestamp":1764432883,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals recently received a positive opinion from the European Medicines Agency’s Committee for Donidalorsen, a drug for hereditary angioedema, with a final regulatory decision expected in early 2026, and also announced plans to raise US$700 million through Convertible Senior Notes due 2030.\nRecent insider transactions, including major share sales and option exercises by executives and directors, occurred alongside these regulatory and corporate financing developments.\nWe’ll...","market":"hk","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/why-ionis-pharmaceuticals-ions-is-up-87-after-donidalorsen-e","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/why-ionis-pharmaceuticals-ions-is-up-87-after-donidalorsen-e","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4081","IONS","EMA","BK4139"],"gpt_icon":0},{"id":"2587758113","title":"Ionis Pharmaceuticals EVP Chief Human Resources Officer Shannon L. Devers Reports Sale of Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2587758113","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2587758113?lang=en_us&edition=fundamental","pubTime":"2025-11-29 06:52","pubTimestamp":1764370347,"startTime":"0","endTime":"0","summary":"Shannon L. Devers, EVP and Chief Human Resources Officer of Ionis Pharmaceuticals Inc., has reported a disposal of common shares of the company. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on November 28, 2025, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251128:nNDL4d88rv:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2587758115","title":"Ionis Pharmaceuticals Director Joseph Klein III Reports Disposal of Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2587758115","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2587758115?lang=en_us&edition=fundamental","pubTime":"2025-11-29 06:52","pubTimestamp":1764370344,"startTime":"0","endTime":"0","summary":"Joseph Klein III, Director at Ionis Pharmaceuticals Inc., has reported a disposal of common shares of the company. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on November 28, 2025, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251128:nNDL80d5Ll:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Ionis Pharmaceuticals Director Joseph Klein III Reports Disposal of Common Shares","news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2585160856","title":"Director’s Multi-Million Dollar Stock Sale Shakes Ionis Pharmaceuticals","url":"https://stock-news.laohu8.com/highlight/detail?id=2585160856","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2585160856?lang=en_us&edition=fundamental","pubTime":"2025-11-21 10:13","pubTimestamp":1763691185,"startTime":"0","endTime":"0","summary":"New insider activity at Ionis Pharmaceuticals ( ($IONS) ) has taken place on November 20, 2025. Director Joan Herman recently sold 44,000 shares of...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/insider-trading/directors-multi-million-dollar-stock-sale-shakes-ionis-pharmaceuticals-insider-trading?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/insider-trading/directors-multi-million-dollar-stock-sale-shakes-ionis-pharmaceuticals-insider-trading?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2585316330","title":"Ionis Pharmaceuticals Director Joan E. Herman Reports Sale of Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2585316330","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2585316330?lang=en_us&edition=fundamental","pubTime":"2025-11-21 06:12","pubTimestamp":1763676763,"startTime":"0","endTime":"0","summary":"Joan E. Herman, Director of Ionis Pharmaceuticals Inc., reported a disposal of common shares of the company. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on November 20, 2025, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251120:nNDLB5ZYD:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Ionis Pharmaceuticals Director Joan E. Herman Reports Sale of Common Shares","news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2584492103","title":"Ionis Announces Proposed Convertible Offering To Refinance 2026 Convertible Notes","url":"https://stock-news.laohu8.com/highlight/detail?id=2584492103","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2584492103?lang=en_us&edition=fundamental","pubTime":"2025-11-20 01:20","pubTimestamp":1763572846,"startTime":"0","endTime":"0","summary":"Nov 12 (Reuters) - Ionis Pharmaceuticals Inc ::*IONIS ANNOUNCES PROPOSED CONVERTIBLE OFFERING TO REFINANCE 2026 CONVERTIBLE NOTES*IONIS PHARMACEUTICALS INC - TO OFFER $700 MILLION CONVERTIBLE NOTES DU","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251119:nRSD6m7DSX:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2584925120","title":"Arrowhead Pharmaceuticals Poised for Commercial Transition After First FDA Approval, RBC Says","url":"https://stock-news.laohu8.com/highlight/detail?id=2584925120","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2584925120?lang=en_us&edition=fundamental","pubTime":"2025-11-20 00:35","pubTimestamp":1763570132,"startTime":"0","endTime":"0","summary":"Arrowhead Pharmaceuticals (ARWR) is poised to transition to a commercial group after receiving its first drug approval from the US Food and Drug Administration, RBC Capital Markets said in a Tuesday n","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["IONS","BK4139","BK4588","BK4585","ARWR"],"gpt_icon":0},{"id":"2584455279","title":"Ionis Pharmaceuticals (IONS) Gets a Hold from Bernstein","url":"https://stock-news.laohu8.com/highlight/detail?id=2584455279","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2584455279?lang=en_us&edition=fundamental","pubTime":"2025-11-19 19:56","pubTimestamp":1763553368,"startTime":"0","endTime":"0","summary":"In a report released yesterday, William Pickering from Bernstein maintained a Hold rating on Ionis Pharmaceuticals, with a price target of $65.00. ...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/ionis-pharmaceuticals-ions-gets-a-hold-from-bernstein-blurbs?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/ionis-pharmaceuticals-ions-gets-a-hold-from-bernstein-blurbs?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2584951746","title":"US FDA approves Arrowhead's genetic disorder drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2584951746","media":"Reuters","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2584951746?lang=en_us&edition=fundamental","pubTime":"2025-11-19 00:19","pubTimestamp":1763482783,"startTime":"0","endTime":"0","summary":"US FDA approves Arrowhead's genetic disorder drugNov 18 (Reuters) - The U.S. Food and Drug Administration approved Arrowhead Pharmaceuticals' ARWR.O drug for a type of genetic disorder that causes ext","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251118:nL4N3WU1A0:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4588","BK4585","BK4139","ARWR"],"gpt_icon":0},{"id":"2584779674","title":"Ionis Pharmaceuticals Completes $770M Convertible Notes Offering","url":"https://stock-news.laohu8.com/highlight/detail?id=2584779674","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2584779674?lang=en_us&edition=fundamental","pubTime":"2025-11-18 05:31","pubTimestamp":1763415082,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals ( ($IONS) ) has issued an update. On November 17, 2025, Ionis Pharmaceuticals completed a private offering of $770 million in...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-completes-770m-convertible-notes-offering?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-completes-770m-convertible-notes-offering?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2584671779","title":"Ionis Pharmaceuticals Announces $700 Million Convertible Senior Notes Offering","url":"https://stock-news.laohu8.com/highlight/detail?id=2584671779","media":"Reuters","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2584671779?lang=en_us&edition=fundamental","pubTime":"2025-11-18 05:06","pubTimestamp":1763413618,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals Inc. has announced a proposed private offering of $700 million aggregate principal amount of Convertible Senior Notes due 2030. The company also plans to grant initial purchasers an option to buy up to an additional $70 million principal amount of notes within a 13-day period starting from the initial issuance date. The notes will be general unsecured obligations of Ionis and will accrue interest payable semiannually in arrears. Upon conversion, Ionis may settle the notes in cash, common stock, or a combination of both, at its discretion. The interest rate, initial conversion rate, and other terms will be determined at the time of pricing. Proceeds from the offering are expected to be used for repurchasing or repaying the company's 0% Convertible Senior Notes due 2026. No URL for the full prospectus is included in the document.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251117:nNDL37zGjk:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2584864704","title":"Biogen Gets CHMP Backing for Higher-Dose Spinraza","url":"https://stock-news.laohu8.com/highlight/detail?id=2584864704","media":"Dow Jones","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2584864704?lang=en_us&edition=fundamental","pubTime":"2025-11-17 19:40","pubTimestamp":1763379600,"startTime":"0","endTime":"0","summary":"Biogen said a key European regulatory committee has recommended approval of a high-dose regimen of its Spinraza drug for the neuromuscular disease spinal muscular atrophy, or SMA.Biogen on Monday said the positive opinion from the European Medicines Agency's Committee for Medicinal Products for Human Use covers the high-dose regimen of Spinraza for the treatment of 5q SMA, which represents about 95% of all SMA cases.The European Commission, which generally follows CHMP's advice, will now review the recommendation, with a decision expected in January, the Cambridge, Mass., biotechnology company said.The U.S. Food and Drug Administration is reviewing Biogen's application for the high-dose regimen, with a decision due by early April.Spinal muscular atrophy is a rare genetic disease characterized by a loss of motor neurons in the spinal cord and lower brain stem, resulting in severe, progressive muscle atrophy and weakness.Spinraza generated worldwide sales of $1.19 billion for the first n","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","IE00B19Z9P08.USD","LU0320765992.SGD","LU0109394709.USD","LU0234570918.USD","LU0889565916.HKD","BK4533","BK4139","BK4588","BK4087","BK4585","BK4532","IE00B19Z9Z06.USD","CHMP","IE00B894F039.SGD","BIIB"],"gpt_icon":0},{"id":"2583506953","title":"Ionis Pharmaceuticals announces CHMP opinion recommending Dawnzera approval","url":"https://stock-news.laohu8.com/highlight/detail?id=2583506953","media":"TIPRANKS","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2583506953?lang=en_us&edition=fundamental","pubTime":"2025-11-14 20:46","pubTimestamp":1763124391,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals (IONS) and Otsuka Pharmaceutical announced that the Committee for Medicinal Products for Human Use of the European Medicines ...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-announces-chmp-opinion-recommending-dawnzera-approval-thefly?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-announces-chmp-opinion-recommending-dawnzera-approval-thefly?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS","BK4139","CHMP","BK4087"],"gpt_icon":0},{"id":"2583604505","title":"Ionis Pharmaceuticals Says Dawnzera Recommended for Approval in EU for Hereditary Angioedema","url":"https://stock-news.laohu8.com/highlight/detail?id=2583604505","media":"MT Newswires Live","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2583604505?lang=en_us&edition=fundamental","pubTime":"2025-11-14 20:36","pubTimestamp":1763123770,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals  said Friday that it has received a positive opinion from the European Medicines Agency's Committee for Medicinal Products for Human Use for Dawnzera to prevent recurrent attacks of hereditary angioedema in patients aged 12 years and older.The company said the opinion was based on results from phase 3 studies in which Dawnzera demonstrated a \"significant and sustained reduction\" in mean monthly hereditary angioedema attack rate, including when self-administered via autoinjector.The European Commission is expected to take a decision in Q1 of 2026, the company said.Shares of Ionis Pharmaceuticals were down more than 3% in recent premarket activity Friday.","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4139","BK4156","IONS"],"gpt_icon":0},{"id":"2583250878","title":"Ionis Pharmaceuticals Wins CHMP Backing for DAWNZERA in Hereditary Angioedema Prevention","url":"https://stock-news.laohu8.com/highlight/detail?id=2583250878","media":"Reuters","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2583250878?lang=en_us&edition=fundamental","pubTime":"2025-11-14 20:00","pubTimestamp":1763121634,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals Inc. announced that the Committee for Medicinal Products for Human Use  of the European Medicines Agency has issued a positive opinion recommending approval of DAWNZERA  for the routine prevention of recurrent attacks of hereditary angioedema  in adults and adolescents aged 12 years and older. The recommendation is based on robust clinical evidence from the Phase 3 OASIS-HAE and OASISplus studies, which demonstrated significant reductions in HAE attack rates. The final approval decision now rests with the European Commission, with a decision expected in the first quarter of 2026. Otsuka Pharmaceutical Co., Ltd. holds exclusive rights to bring donidalorsen to patients in Europe and Asia Pacific.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, i","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251114:nNDL950lV3:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","IONS"],"gpt_icon":0}],"pageSize":20,"totalPage":10,"pageCount":6,"totalSize":198,"code":"91000000","status":"200"}]}}