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DKK1 levels highly correlated with clinical activity in CRC population. ORR benefit with sirexatamab observed across multiple potential Phase 3 CRC populations. Preparations will begin for a registrational Phase 3 study in second-line CRC patients. DisTinGuish Part C study in gastric cancer demonstrates activity in biomarker populations,but not the signal necessary to advance into Phase 3. CAMBRIDGE, Mass., Jan. 28, 2025 /PRNewswire/ -- Leap Therapeutics, Inc. , a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today announced positive initial data from Part B of the DeFianCe study evaluating sirexatamab  in combination with bevacizumab and chemotherapy as a second-line treatment for patients with advanced colorectal cancer , and initial data from Part C of the DisTinGuish stud","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/leap-therapeutics-reports-initial-clinical-120000712.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/leap-therapeutics-reports-initial-clinical-120000712.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4139","BK4113","BK4213","LPTX","BK4505","BK4588","PFS","IE00BMPRXQ63.HKD","LU0456854461.SGD","BK4141","ORR","LU0348723411.USD","IE00BMPRXR70.SGD","BK4211","CRC","BK4161","ITT","BK4585","MSS","BK4543","LENZ","IE00BMPRXN33.USD","LU0054578231.USD","LU0053671581.USD","BK4195","BK4563","LU0266512127.USD"],"gpt_icon":1},{"id":"2504954311","title":"ADVISORY-Alert on fund raise wrongly tagged to Leap Therapeutics withdrawn","url":"https://stock-news.laohu8.com/highlight/detail?id=2504954311","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2504954311?lang=en_us&edition=fundamental","pubTime":"2025-01-18 00:20","pubTimestamp":1737130835,"startTime":"0","endTime":"0","summary":"An alert on retail platform Leap raising $20 million was inadvertently tagged to Leap Therapeutics   , an unrelated company, and has been withdrawn.   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OnsiPresident & Chief Executive OfficerLeap Therapeutics, Inc.617-714-0360donsi@leaptx.com","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/C97iwlMJ_.mZUFTbQfAyeA--~B/aD0xMTU7dz00MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/prnewswire.com/8dc795371648bf5b4f6c87c19d7aa633","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/C97iwlMJ_.mZUFTbQfAyeA--~B/aD0xMTU7dz00MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/prnewswire.com/8dc795371648bf5b4f6c87c19d7aa633"],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/leap-therapeutics-participate-piper-sandler-120000604.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/leap-therapeutics-participate-piper-sandler-120000604.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"conferences","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["HCSG","BK4137","LENZ","LPTX","BK4563","BK4139","BK4505"],"gpt_icon":0},{"id":"2483788653","title":"Leap Therapeutics Inc reports results for the quarter  - Earnings Summary","url":"https://stock-news.laohu8.com/highlight/detail?id=2483788653","media":"Reuters","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2483788653?lang=en_us&edition=fundamental","pubTime":"2024-11-13 22:16","pubTimestamp":1731507417,"startTime":"0","endTime":"0","summary":"* Leap Therapeutics Inc    reported a quarterly adjusted loss of 44 cents per share for the quarter , higher than the same quarter last year, when the company reported EPS of -51 cents.  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Earnings Preview","url":"https://stock-news.laohu8.com/highlight/detail?id=2482482524","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2482482524?lang=en_us&edition=fundamental","pubTime":"2024-11-09 01:01","pubTimestamp":1731085280,"startTime":"0","endTime":"0","summary":"Leap Therapeutics Inc  expected to post a loss of48cents a share - Earnings Preview Leap Therapeutics Inc LPTX.OQ LPTX.O is expected to show no change in quarterly revenue when it reports  results on ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20241108:nL8N3MF2YR:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LPTX"],"gpt_icon":0},{"id":"2471808079","title":"Leap Therapeutics Announces Completion of Enrollment in Part B of the Defiance Study of Dkn-01 for the Treatment of Colorectal Cancer Patients","url":"https://stock-news.laohu8.com/highlight/detail?id=2471808079","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2471808079?lang=en_us&edition=fundamental","pubTime":"2024-09-30 19:00","pubTimestamp":1727694005,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20240930:nTUABNQDYQ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4563","BK4505","BK4139","LPTX"],"gpt_icon":0},{"id":"2471806945","title":"Leap Therapeutics Announces Completion of Enrollment in Part B of the DeFianCe Study of DKN-01 for the Treatment of Colorectal Cancer Patients","url":"https://stock-news.laohu8.com/highlight/detail?id=2471806945","media":"PR Newswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2471806945?lang=en_us&edition=fundamental","pubTime":"2024-09-30 19:00","pubTimestamp":1727694000,"startTime":"0","endTime":"0","summary":"CAMBRIDGE, Mass., Sept. 30, 2024 /PRNewswire/ -- Leap Therapeutics, Inc. , a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today announced that enrollment of 188 patients has been completed in the randomized controlled Part B of the DeFianCe study evaluating DKN-01, Leap's anti-Dickkopf-1  antibody, in combination with standard of carebevacizumab and chemotherapy as a second-line treatment for patients with advanced colorectal cancer .FORWARD-LOOKING STATEMENTSThis press release contains forward-looking statements within the meaning of the federal securities laws. Such statements are based upon current plans, estimates and expectations of the management of Leap that are subject to various risks and uncertainties that could cause actual results to differ materially from such statements. The inclusion of forward-looking statements should not be regarded as a representation that such plans, estimates and expectations will be achieved. 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