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NLS Pharmaceutics Ltd.

1.47

+0.04002.80%

Post-market: 1.46-0.0100-0.68%18:36 EDT

Volume:47.44K

Turnover:70.64K

Market Cap:1.72M

PE:-0.22

High:1.53

Open:1.44

Low:1.44

Close:1.43

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Overview Company News Filings

NLS Pharmaceutics Study Suggests Mazindol May Help Treat Fentanyl Use Disorder

MT Newswires Live

NLS Pharmaceutics Reports Positive Results in Fentanyl Study

BRIEF-Nls Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward In Animal Models

NLS Pharmaceutics’ Mazindol reduces fentanyl-induced reward in animal models

NLS Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models

THOMSON REUTERS

Press Release: NLS Pharmaceutics Announces Positive Results from Study KO-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models

NLS Pharmaceutics Announces Strategic Merger and Advances in Therapeutic Pipeline

Press Release: NLS Pharmaceutics CEO Issues Letter to Shareholders

NLS Pharmaceutics Announces New Preclinical Data for AEX-2, Expanding the Therapeutic Potential of its Non-Sulfonamide Dual Orexin Receptor Agonist Platform

NLS Pharmaceutics and Kadimastem complete pre-IND diabetes meeting with FDA

Kadimastem and Itolerance Successfully Complete Pre-Ind Meeting With the FDA for Its Type 1 Diabetes Treatment

THOMSON REUTERS

Kadimastem and iTolerance Successfully Complete Pre-IND Meeting with the FDA for its Type 1 Diabetes Treatment

NLS Pharmaceutics files $75M mixed securities shelf

BRIEF-NLS Pharmaceutics And Kadimastem Unveil Multi-Target Approach To Diabetes

NLS Pharmaceutics and Kadimastem Announce Merger to Innovate Diabetes Treatment

NLS Pharmaceutics and Kadimastem Unveil Multi-Target Approach to Diabetes, Expanding Beyond Glp-1 Therapies

THOMSON REUTERS

NLS Pharmaceutics Amends Merger Agreement with Kadimastem

Dow Edges Lower; Exxon Mobil Earnings Top Views

NLS Pharmaceutics Says Kadimastem Shareholders Approve Merger With NLS; Shares Rise

MT Newswires Live

Kadimastem Shareholders Approved the Merger With NLS Pharmaceutics

THOMSON REUTERS

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On April 15, 2025, NLS Pharmaceutics announced positive results from a preclinical stu...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-reports-positive-results-in-fentanyl-study?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-reports-positive-results-in-fentanyl-study?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","NLSP"],"gpt_icon":0},{"id":"2527411645","title":"BRIEF-Nls Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward In Animal Models","url":"https://stock-news.laohu8.com/highlight/detail?id=2527411645","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527411645?lang=en_us&edition=fundamental","pubTime":"2025-04-15 21:13","pubTimestamp":1744722795,"startTime":"0","endTime":"0","summary":"BRIEF-Nls Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward In Animal ModelsApril 15 (Reuters) - Kadimastem Ltd KDST.TA:NLS PHARMACEUTIC","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250415:nFWN3QT0Z4:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["NLSP"],"gpt_icon":0},{"id":"2527414363","title":"NLS Pharmaceutics’ Mazindol reduces fentanyl-induced reward in animal models","url":"https://stock-news.laohu8.com/highlight/detail?id=2527414363","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527414363?lang=en_us&edition=fundamental","pubTime":"2025-04-15 21:06","pubTimestamp":1744722395,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics (NLSP) announced positive results from Study KO-943, a preclinical investigation evaluating the efficacy of Mazindol in mitigatin...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-mazindol-reduces-fentanyl-induced-reward-in-animal-models?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-mazindol-reduces-fentanyl-induced-reward-in-animal-models?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0323591593.USD","SG9999004303.SGD","LU2237957902.USD","LU0545039389.USD","LU1162221912.USD","BK4610","LU0661504455.SGD","LU2506951875.HKD","LU0289960550.SGD","LU0096364046.USD","LU0098860793.USD","LU0795875086.SGD","LU2237443549.SGD","LU0823417737.USD","LU1059921491.USD","LU2279689827.SGD","LU1670710588.SGD","IE00BGHQF631.EUR","LU2264538146.SGD","SG9999002224.SGD","LU1732800096.USD","SG9999014542.SGD","IE00B42XCP33.USD","LU2125154935.USD","LU0553294199.USD","SG9999015358.SGD","LU1732799900.SGD","LU0957791311.USD","SG9999003800.SGD","BK4559","LU2506952170.USD","BK4177","IE00BVYPNV92.GBP","BK4588","BK4533","LU1815333072.USD","LU0234572021.USD","BK4007","LU1196500208.SGD","SG9999014575.USD","LU2506951958.HKD","NLSP","LU0795875169.SGD","SG9999014559.SGD","SG9999015341.SGD","LU1988902786.USD","LU1718418525.SGD","LU0175139822.USD","SG9999002232.USD"],"gpt_icon":0},{"id":"2527419659","title":"NLS Pharmaceutics Announces Positive Results From Study Ko-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models","url":"https://stock-news.laohu8.com/highlight/detail?id=2527419659","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527419659?lang=en_us&edition=fundamental","pubTime":"2025-04-15 21:00","pubTimestamp":1744722012,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250415:nFWN3QT0Z4:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2527841992","title":"Press Release: NLS Pharmaceutics Announces Positive Results from Study KO-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models","url":"https://stock-news.laohu8.com/highlight/detail?id=2527841992","media":"Dow Jones","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527841992?lang=en_us&edition=fundamental","pubTime":"2025-04-15 21:00","pubTimestamp":1744722000,"startTime":"0","endTime":"0","summary":"Non-opioid, multi-mechanism profile positions Mazindol as a differentiated asset in addiction therapeutics. Favorable results support potential expansion into high-value markets beyond ADHD and narcolepsy. Study KO-943 utilized a validated CPP paradigm in C57BL/6J mice to measure the rewarding properties of fentanyl and the modulatory effects of Mazindol. Mice were divided into four groups: vehicle control, fentanyl-only , and fentanyl with Mazindol co-treatment . The primary outcome measured was the change in time spent in the drug-paired compartment after conditioning.\"We believe that these data provide compelling evidence of the multi-target potential of Mazindol to address the opioid crisis through a novel mechanism of action,\" said Dr. Eric Konofal, MD, PhD, Chief Scientific Officer of NLS Pharmaceutics. \"By targeting key pathways--including partial mu-opioid receptor  agonism, serotonin 5-HT1A modulation, and orexin-2 receptor  activity--Mazindol offers a robust and differentiate","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":"Press Release: NLS Pharmaceutics Announces Positive Results from Study KO-943 Demonstrating Mazindol Reduces Fentanyl-Induced Reward in Animal Models","news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["NLSP"],"gpt_icon":1},{"id":"2518227127","title":"NLS Pharmaceutics Announces Strategic Merger and Advances in Therapeutic Pipeline","url":"https://stock-news.laohu8.com/highlight/detail?id=2518227127","media":"TIPRANKS","labels":["merge"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518227127?lang=en_us&edition=fundamental","pubTime":"2025-03-10 21:48","pubTimestamp":1741614517,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics ( ($NLSP) ) has issued an announcement. On March 10, 2025, NLS Pharmaceutics announced significant strategic milestones, includin...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-announces-strategic-merger-and-advances-in-therapeutic-pipeline?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/nls-pharmaceutics-announces-strategic-merger-and-advances-in-therapeutic-pipeline?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"merge","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","NLSP"],"gpt_icon":0},{"id":"2518241019","title":"Press Release: NLS Pharmaceutics CEO Issues Letter to Shareholders","url":"https://stock-news.laohu8.com/highlight/detail?id=2518241019","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518241019?lang=en_us&edition=fundamental","pubTime":"2025-03-10 19:00","pubTimestamp":1741604400,"startTime":"0","endTime":"0","summary":"ZURICH, March 10, 2025 /PRNewswire/ -- NLS Pharmaceutics Ltd. , a Swiss clinical-stage biopharmaceutical company focused on developing innovative therapies for central nervous system  disorders, today issued a letter to its shareholders.We are thrilled to share the significant progress and strategic milestones NLS Pharmaceutics has achieved, positioning our company for a transformative future in the biotechnology sector.In collaboration with iTolerance Inc., Kadimastem has successfully completed a pre-Investigational New Drug  meeting with the U.S. Food and Drug Administration  for iTOL-102, a potential breakthrough therapy for Type 1 Diabetes. This innovative approach combines Kadimastem's IsletRx cells with iTolerance's immunomodulator, aiming to cure Type 1 Diabetes without the need for lifelong immune suppression.The diabetes treatment landscape has experienced significant growth, underscored by notable mergers and acquisitions. For instance, Novo Nordisk's acquisition of Inversago","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["QID","SQQQ","R","MNQmain","TQQQ","CNS","QLD","NVIW.SI","PSQ","NLSP","TSYW.SI","USJW.SI","BK4007","NQmain",".IXIC","BK4022","BK4232","USAW.SI","BK4135"],"gpt_icon":1},{"id":"2514059108","title":"NLS Pharmaceutics Announces New Preclinical Data for AEX-2, Expanding the Therapeutic Potential of its Non-Sulfonamide Dual Orexin Receptor Agonist Platform","url":"https://stock-news.laohu8.com/highlight/detail?id=2514059108","media":"PR Newswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514059108?lang=en_us&edition=fundamental","pubTime":"2025-02-27 20:00","pubTimestamp":1740657600,"startTime":"0","endTime":"0","summary":"ZRICH, Switzerland, Feb. 27, 2025 /PRNewswire/ -- NLS Pharmaceutics Ltd.   , in collaboration with Aexon Labs Inc. , is pleased to announce new preclinical findings on AEX-2, reinforcing its potential as a first-in-class non-sulfonamide dual orexin receptor agonist  for narcolepsy and related neurological disorders. These results build upon the Company's multi-target neurodegenerative strategy, which also includes AEX-41, demonstrating a novel and promising approach to addressing sleep disorders, neuroinflammation, and metabolic dysfunction.Recent preclinical advancements have demonstrated the multi-target potential of DOXA compounds, including AEX-41 and AEX-2, in redefining sleep-wake regulation and neuroprotection. In orexin-deficient mouse models, these compounds exhibited strong wake-promoting effects and sleep-wake cycle stabilization, reinforcing their potential as next-generation therapeutics. Key findings include:. Wakefulness Enhancement: AEX-2 significantly increased total w","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/nls-pharmaceutics-announces-preclinical-data-120000386.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/nls-pharmaceutics-announces-preclinical-data-120000386.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["NLSP","NLSPW","BK4007"],"gpt_icon":0},{"id":"2514097571","title":"NLS Pharmaceutics and Kadimastem complete pre-IND diabetes meeting with FDA","url":"https://stock-news.laohu8.com/highlight/detail?id=2514097571","media":"TIPRANKS","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514097571?lang=en_us&edition=fundamental","pubTime":"2025-02-25 22:10","pubTimestamp":1740492613,"startTime":"0","endTime":"0","summary":"NLS Pharmaceutics (NLSP) and Kadimastem, a clinical-stage company specializing in “off-the-shelf” allogeneic cell therapy products for neurodegener...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-and-kadimastem-complete-pre-ind-diabetes-meeting-with-fda?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/nls-pharmaceutics-and-kadimastem-complete-pre-ind-diabetes-meeting-with-fda?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","NLSP"],"gpt_icon":0},{"id":"2514375092","title":"Kadimastem and Itolerance Successfully Complete Pre-Ind Meeting With the FDA for Its Type 1 Diabetes Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2514375092","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514375092?lang=en_us&edition=fundamental","pubTime":"2025-02-25 22:05","pubTimestamp":1740492315,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250225:nTUA9YBWXT:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["NLSP","BK4007"],"gpt_icon":0},{"id":"2514097312","title":"Kadimastem and iTolerance Successfully Complete Pre-IND Meeting with the FDA for its Type 1 Diabetes Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2514097312","media":"PR Newswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514097312?lang=en_us&edition=fundamental","pubTime":"2025-02-25 22:05","pubTimestamp":1740492300,"startTime":"0","endTime":"0","summary":"Companies Advance Collaborative Clinical Development of iTOL-102: A Potential Cure for Diabetes Without the Need for Chronic Life-long Immune Suppression. 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