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The move was backed by solid volume with far more shares changing hands than in a normal session. This compares to the stock's 4.5% gain over the past four weeks.Last month, the company achieved alignment with various regulatory agencies across the world related to the design of the phase III EMPEROR study on its pipeline candidate, zorevunersen, for treating Dravet syndrome. Following discussions with the FDA, the European Medicines Agency and Japan’s Pharmaceuticals and Medical Devices Agency, Stoke Therapeutics decided on the protocol for the EMPEROR study, which will evaluate two loading doses of zorevunersen  followed by two maintenance doses of 45mg for 52 weeks compared with sham in children and adolescents aged two to less than 18 years with Dravet syndrome. The growing optimism related to the development of zorevunersen might have driven the recent share price rally.Anika Therapeutics ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/strength-seen-stoke-therapeutics-stok-135100563.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["ANIK","STOK","BK4139"],"gpt_icon":0},{"id":"2506327205","title":"The 13% return this week takes Stoke Therapeutics' (NASDAQ:STOK) shareholders one-year gains to 116%","url":"https://stock-news.laohu8.com/highlight/detail?id=2506327205","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2506327205?lang=en_us&edition=fundamental","pubTime":"2025-01-27 18:22","pubTimestamp":1737973360,"startTime":"0","endTime":"0","summary":"While Stoke Therapeutics, Inc.  shareholders are probably generally happy, the stock hasn't had particularly good run recently, with the share price falling 14% in the last quarter. But that doesn't detract from the splendid returns of the last year. We're very pleased to report the share price shot up 116% in that time. So some might not be surprised to see the price retrace some. More important, going forward, is how the business itself is going.On the back of a solid 7-day performance, let's check what role the company's fundamentals have played in driving long term shareholder returns.Because Stoke Therapeutics made a loss in the last twelve months, we think the market is probably more focussed on revenue and revenue growth, at least for now. Shareholders of unprofitable companies usually desire strong revenue growth. That's because it's hard to be confident a company will be sustainable if revenue growth is negligible, and it never makes a profit.Get in touch with us directly. Alt","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/13-return-week-takes-stoke-102240223.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["SQQQ","BK4139","USAW.SI","IE00BKPKM429.USD","USJW.SI","BK4585","BK4112","TQQQ","NDAQ","LU2095319765.USD","NVIW.SI","TSYW.SI","NQmain","LU2210150020.SGD",".IXIC","PSQ","QLD","MNQmain","IE00B64PRP62.GBP","LU2210149790.SGD","IE00B3QW5Z07.USD","STOK","IE00BGHQF748.EUR","BK4588","QID"],"gpt_icon":1},{"id":"2505703668","title":"Possible Signal As Stoke Therapeutics Insiders Sell US$523k In Stock","url":"https://stock-news.laohu8.com/highlight/detail?id=2505703668","media":"Simply Wall St.","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2505703668?lang=en_us&edition=fundamental","pubTime":"2025-01-22 19:18","pubTimestamp":1737544718,"startTime":"0","endTime":"0","summary":"Despite the fact that Stoke Therapeutics, Inc. (NASDAQ:STOK) stock rose 13% last week, insiders who sold US$523k worth...","market":"sg","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-stok/stoke-therapeutics/news/possible-signal-as-stoke-therapeutics-insiders-sell-us523k-i","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4139","LENZ","STOK"],"gpt_icon":0},{"id":"2504929191","title":"Is it a Good Idea to Invest in Stoke Therapeutics Stock Now?","url":"https://stock-news.laohu8.com/highlight/detail?id=2504929191","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2504929191?lang=en_us&edition=fundamental","pubTime":"2025-01-17 23:28","pubTimestamp":1737127680,"startTime":"0","endTime":"0","summary":"Massachusett-based Stoke Therapeutics STOK is making rapid progress with the development of zorevunersen , its investigational candidate for treating Dravet syndrome, a severe and progressive genetic epilepsy.Zorevunersen is a novel proprietary antisense oligonucleotide with the potential to become the first disease-modifying therapy to address the genetic cause of Dravet syndrome.The FDA granted a Breakthrough Therapy designation to zorevunersen for treating Dravet syndrome in December 2024.In the past year, shares of Stoke Therapeutics have rallied 94.7% against the industry’s decline of 13.6%.In the past 60 days, estimates for Voyager Therapeutics’ loss per share have narrowed from $1.72 to $1.48 for 2025. In the past year, shares of VYGR have plunged 30.6%.In the past 60 days, estimates for CytomX Therapeutics’ loss per share have narrowed from 46 cents to 35 cents for 2025. In the past year, shares of CTMX have decreased 49.5%.CTMX’s earnings beat estimates in two of the trailing ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/good-idea-invest-stoke-therapeutics-152800824.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["VYGR","CTMX","BK4196","BK4139","STOK","LENZ","CSTL"],"gpt_icon":0},{"id":"2501575955","title":"Stoke Therapeutics negative reaction after STK-001 update overdone, says Chardan","url":"https://stock-news.laohu8.com/highlight/detail?id=2501575955","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501575955?lang=en_us&edition=fundamental","pubTime":"2025-01-08 06:30","pubTimestamp":1736289029,"startTime":"0","endTime":"0","summary":"Chardan keeps a Buy rating and $24 price target on Stoke Therapeutics (STOK) after the company provided a “long-awaited” update for its Phase 3 stu...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/stoke-therapeutics-negative-reaction-after-stk-001-update-overdone-says-chardan?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/stoke-therapeutics-negative-reaction-after-stk-001-update-overdone-says-chardan?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LENZ","BK4139","STOK"],"gpt_icon":0},{"id":"2501781769","title":"Stoke Therapeutics Reports Alignment With Regulators for Dravet Syndrome Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2501781769","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501781769?lang=en_us&edition=fundamental","pubTime":"2025-01-08 00:19","pubTimestamp":1736266783,"startTime":"0","endTime":"0","summary":"Stoke Therapeutics  said Tuesday it has reached alignment with global regulatory agencies on the design of its phase 3 trial of zorevunersen to treat Dravet syndrome.The company said it has finalized the trial protocol after interactions with the US Food and Drug Administration, the EU's European Medicines Agency, and Japan's Pharmaceuticals and Medical Devices Agency.The primary endpoint of the study will be a decrease in major motor seizure frequency, the company said, adding key secondary endpoints will include improvements in cognition and behavior. It plans to start the trial in mid-2025.Stoke also said that zorevunersen has recently obtained US FDA's breakthrough therapy designation.The company's shares were falling past 13% in recent trading.Price: 9.52, Change: -1.50, Percent Change: -13.61","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["LENZ","STOK","BK4139"],"gpt_icon":0},{"id":"2501869337","title":"Wedbush Raises Stoke Therapeutics' Price Target to $19 From $17, Keeps Outperform Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2501869337","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501869337?lang=en_us&edition=fundamental","pubTime":"2025-01-07 23:43","pubTimestamp":1736264586,"startTime":"0","endTime":"0","summary":"Stoke Therapeutics (STOK) has an average rating of Buy and mean price target of $22.29, according to analysts polled by FactSet.(MT Newswires covers equity, commodity and economic research from major ","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate","earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["STOK","LENZ"],"gpt_icon":0},{"id":"2501820894","title":"BRIEF-Stoke Therapeutics Plans To Initiate Phase 3 Study Of Zorevunersen To Treat Dravet Syndrome On Alignment With Global Regulatory Agencies","url":"https://stock-news.laohu8.com/highlight/detail?id=2501820894","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501820894?lang=en_us&edition=fundamental","pubTime":"2025-01-07 20:21","pubTimestamp":1736252483,"startTime":"0","endTime":"0","summary":"Jan 7  - Stoke Therapeutics Inc   :   * STOKE THERAPEUTICS ANNOUNCES ALIGNMENT WITH GLOBAL REGULATORY AGENCIES AND PLANS TO INITIATE A PHASE 3 STUDY OF ZOREVUNERSEN AS POTENTIALLY THE FIRST DISEASE-MODIFYING MEDICINE FOR THE TREATMENT OF DRAVET SYNDROME   * STOKE THERAPEUTICS : FDA BREAKTHROUGH THERAPY DESIGNATION POSITIONS ZOREVUNERSEN ON EFFICIENT DEVELOPMENT PATH; PLANS TO START PHASE 3 IN MID-2025Source text:    Further company coverage:    ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.rkd.refinitiv.com/api/News/News.svc/REST/News_1/RetrieveStoryML_1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LENZ","BK4139","STOK"],"gpt_icon":0},{"id":"2501208844","title":"Stoke Therapeutics finalizes EMPEROR study program with regulatory agencies","url":"https://stock-news.laohu8.com/highlight/detail?id=2501208844","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501208844?lang=en_us&edition=fundamental","pubTime":"2025-01-07 20:10","pubTimestamp":1736251842,"startTime":"0","endTime":"0","summary":"Stoke Therapeutics (STOK) announced alignment with global regulatory agencies on the design of the company’s Phase 3 EMPEROR study of zorevunersen ...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/stoke-therapeutics-finalizes-emperor-study-program-with-regulatory-agencies?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/stoke-therapeutics-finalizes-emperor-study-program-with-regulatory-agencies?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","LENZ","STOK"],"gpt_icon":0},{"id":"2501927057","title":"Stoke Therapeutics Announces Alignment With Global Regulatory Agencies and Plans to Initiate a Phase 3 Study of Zorevunersen as Potentially the First Disease-Modifying Medicine for the Treatment of Dravet Syndrome","url":"https://stock-news.laohu8.com/highlight/detail?id=2501927057","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501927057?lang=en_us&edition=fundamental","pubTime":"2025-01-07 20:00","pubTimestamp":1736251203,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250107:nTUAC0XZWC:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","STOK"],"gpt_icon":0},{"id":"2501270542","title":"Stoke Therapeutics : FDA Breakthrough Therapy Designation Positions Zorevunersen on Efficient Development Path; Plans to Start Phase 3 in Mid-2025","url":"https://stock-news.laohu8.com/highlight/detail?id=2501270542","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501270542?lang=en_us&edition=fundamental","pubTime":"2025-01-07 20:00","pubTimestamp":1736251203,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250107:nTUAC0XZWC:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","STOK"],"gpt_icon":0},{"id":"2501205804","title":"Stoke Therapeutics Announces Alignment with Global Regulatory Agencies and Plans to Initiate a Phase 3 Study of Zorevunersen as Potentially the First Disease-Modifying Medicine for the Treatment of Dravet Syndrome","url":"https://stock-news.laohu8.com/highlight/detail?id=2501205804","media":"Business Wire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501205804?lang=en_us&edition=fundamental","pubTime":"2025-01-07 20:00","pubTimestamp":1736251200,"startTime":"0","endTime":"0","summary":"– Alignment achieved with U.S. Food and Drug Administration , European Medicines Agency  and Japan’s Pharmaceuticals and Medical Devices Agency  for EMPEROR –。– One-year study of zorevunersen will evaluate reductions in major motor seizure frequency as well as improvements in behavior and cognition in children and adolescents ages 2 to <18 years old –。– FDA Breakthrough Therapy designation positions zorevunersen on efficient development path; Company plans to start Phase 3 in mid-2025 –。\"I have participated as an investigator in many clinical research studies, nearly all of which have been designed to test the next best anti-seizure medicine,\" said Dr. Kelly Knupp, M.D., MSCS, Professor of Pediatrics and Neurology at the University of Colorado, Anshutz Medical Campus and the Dravet Program Director and Epilepsy Program Lead at Children's Hospital Colorado. \"What families and we as clinicians now want are medicines that go beyond reducing seizures to address the neurodevelopmental issue","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/stoke-therapeutics-announces-alignment-global-120000726.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["STOK","LENZ","BK4200","ASO","BK4561","BK4139"],"gpt_icon":0}],"pageSize":16,"totalPage":5,"pageCount":2,"totalSize":68}]}}