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Cohort 2 results, mipletamig has achieved a compelling overall remission rate of 90% among frontline patients, outperforming the doublet remission rate from a venetoclax + azacitidine-only study of 66%.In December 2024, Aptevo Therapeutics announced that 100% of patients achieved remission within 30 days in Cohort 1 of the RAINIER frontline acute myeloid leukemia  Phase 1b trial, including two patients who experienced complete 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additional acute myeloid leukemia patients achieved remission within 30 days of treatment in a trial evaluating mipletamig with standard therapy for patients unfit for intensive chemotherapy.The company said nine of ten frontline patients across two studies have now reached remission with the triplet combination of mipletamig, venetoclax, and azacitidine.Cohort 2 of the trial is nearly fully enrolled, with patients receiving the same dose used in an earlier expansion study, Aptevo said, adding that one patient in the latest cohort progressed and died from causes unrelated to the 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when treated with mipletamig in combination with the standard of care. Triplet Combination with mipletamig continues to outperform doublet combination benchmark. No Cytokine Release Syndrome  has been observed in the RAINIER trial to date. The data builds on previously reported favorable outcomes from RAINIER's Cohort 1 and the completed dose expansion trial where 100% of frontline patients achieved remission. Together with the addition of these interim Cohort 2 results, mipletamig has achieved a compelling overall remission rate of 90% among frontline patients. This outperforms the doublet remission* rate from a venetoclax + azacitidine only study, of 66%. Additionally, the frontline patient triplet therapy CR rate of 70% outperforms the CR rate from a venetoclax + azacitidine only study of 36% .Thus far, all RAINIER patients who achieved remission remain in remission.Two patients achieved remission withing 30 days 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