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The regulatory body has now approved Uplizna for the treatment of adults living with immunoglobulin G4-related disease , a rare immune-mediated inflammatory condition. This marks the second approved indication for the drug.Uplizna is currently approved in the United States for treating adults with a rare autoimmune disease called neuromyelitis optica spectrum disorder.Following the nod, Uplizna became the first and only drug approved by the FDA for the treatment of IgG4-RD, a chronic disease with a significant unmet medical need.The FDA had previously granted a breakthrough therapy designation to Uplizna for the treatment of IgG4-RD.Year to date, shares of Amgen have rallied 18.9% compared with the industry’s rise of 1.2%.Uplizna's Nod for IgG4-RD Based on AMGN's MITIGATE Study. Some better-ranked stocks in the biotech sector are Jazz Pharmaceuticals, Inc. 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Both diseases have a significant unmet medical need.The FDA grants orphan drug designation to support the development of medicines for rare disorders that affect less than 200,000 patients in the United States.Sanofi has developed rilzabrutinib for treating immune thrombocytopenia , another rare, complex autoimmune disorder.A regulatory application seeking approval for rilzabrutinib for treating ITP is currently under review in the United States. A final decision from the FDA is expected on Aug. 29, 2025. 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